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PDB: 20 件
7TAB
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G-925 bound to the SMARCA4 (BRG1) Bromodomain
分子名称: 2-(6-amino-5-phenylpyridazin-3-yl)phenol, Isoform 4 of Transcription activator BRG1
著者Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F.
登録日2021-12-20
公開日2022-08-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.16 Å)
主引用文献GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
J.Med.Chem., 65, 2022
2GRC
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1.5 A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling complex
分子名称: Probable global transcription activator SNF2L4
著者Singh, M, Popowicz, G.M, Krajewski, M, Holak, T.A.
登録日2006-04-24
公開日2007-05-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.
Chembiochem, 8, 2007
6ZS2
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Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol
分子名称: 1,2-ETHANEDIOL, 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol, Transcription activator BRG1
著者Preuss, F, Joerger, A.C, Kraemer, A, Wanior, M, Knapp, S, Structural Genomics Consortium (SGC)
登録日2020-07-15
公開日2020-10-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.
J.Med.Chem., 63, 2020
7TD9
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G-059 bound to the SMARCA4 (BRG1) Bromodomain
分子名称: 4-phenyl-5H-pyridazino[4,3-b]indol-3-amine, Isoform 4 of Transcription activator BRG1
著者Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F.
登録日2021-12-30
公開日2022-08-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
J.Med.Chem., 65, 2022
6HR2
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Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB
分子名称: (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
著者Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A.
登録日2018-09-26
公開日2019-06-12
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Nat.Chem.Biol., 15, 2019
3UVD
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Crystal Structure of the bromodomain of human Transcription activator BRG1 (SMARCA4) in complex with N-Methyl-2-pyrrolidone
分子名称: 1-methylpyrrolidin-2-one, Transcription activator BRG1
著者Filippakopoulos, P, Felletar, I, Picaud, S, Keates, T, Muniz, J, Gileadi, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2011-11-29
公開日2012-01-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
5DKD
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Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe
分子名称: (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one, 1,2-ETHANEDIOL, Transcription activator BRG1, ...
著者Tallant, C, Owen, D.R, Gerstenberger, B.S, Fedorov, O, Savitsky, P, Nunez-Alonso, G, Newman, J.A, Filippakopoulos, P, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Muller, S, Knapp, S.
登録日2015-09-03
公開日2015-10-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe
To Be Published
5EA1
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Crystal Structure of SMARCA4 bromodomain in complex with MPD
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Transcription activator BRG1
著者Lolli, G, Caflisch, A.
登録日2015-10-15
公開日2016-03-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography.
Acs Chem.Biol., 11, 2016
7VRB
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Structure of the Human BRG1/SS18 complex
分子名称: SMARCA4 protein,Protein SSXT
著者Cheng, Y, Chen, F, Zhou, H, Long, J.
登録日2021-10-22
公開日2022-05-25
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.389 Å)
主引用文献Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.
Nat Commun, 13, 2022
7VDT
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The motor-nucleosome module of human chromatin remodeling PBAF-nucleosome complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (207-MER), ...
著者Chen, Z.C, Chen, K.J, Yuan, J.J.
登録日2021-09-07
公開日2022-05-18
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structure of human chromatin-remodelling PBAF complex bound to a nucleosome.
Nature, 605, 2022
6LTH
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Structure of human BAF Base module
分子名称: AT-rich interactive domain-containing protein 1A, SWI/SNF complex subunit SMARCC2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, ...
著者He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y.
登録日2020-01-22
公開日2020-02-12
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structure of nucleosome-bound human BAF complex.
Science, 367, 2020
8QJR
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BRG1 bromodomain in complex with VBC via compound 17
分子名称: (2S,4R)-1-[(2R)-2-[3-[2-[4-[3-[4-[(1R,5S)-3-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]oxycyclobutyl]oxypiperidin-1-yl]ethoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, CHLORIDE ION, Elongin-B, ...
著者Kerry, P.S, Hole, A.J, Perez-Dorado, J.I.
登録日2023-09-13
公開日2024-01-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.17 Å)
主引用文献PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
J.Med.Chem., 67, 2024
7VDV
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The overall structure of human chromatin remodeling PBAF-nucleosome complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2,AT-rich interactive domain-containing protein 2, Actin, ...
著者Chen, Z.C, Chen, K.J, Yuan, J.J.
登録日2021-09-07
公開日2022-05-18
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure of human chromatin-remodelling PBAF complex bound to a nucleosome.
Nature, 605, 2022
6LTJ
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Structure of nucleosome-bound human BAF complex
分子名称: AT-rich interactive domain-containing protein 1A, Actin, cytoplasmic 1, ...
著者He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y.
登録日2020-01-22
公開日2020-02-12
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structure of nucleosome-bound human BAF complex.
Science, 367, 2020
8G1Q
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Co-crystal structure of Compound 1 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB
分子名称: DI(HYDROXYETHYL)ETHER, Elongin-B, Elongin-C, ...
著者Ghimire Rijal, S, Wurz, R.P, Vaish, A.
登録日2023-02-02
公開日2023-07-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.73 Å)
主引用文献Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation.
Nat Commun, 14, 2023
7Y8R
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The nucleosome-bound human PBAF complex
分子名称: ACTB protein (Fragment), ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2, ...
著者Wang, L, Yu, J, Yu, Z, Wang, Q, He, S, Xu, Y.
登録日2022-06-24
公開日2022-12-07
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structure of nucleosome-bound human PBAF complex.
Nat Commun, 13, 2022
8EB1
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Chim2 - Intragenic antimicrobial peptide
分子名称: Unconventional myosin-Ih, Transcription activator BRG1 intragenic antimicrobial chimeric peptide
著者de Freitas, T.V, Oliveira, A.L, Santos, M.A, Brand, G.D.
登録日2022-08-30
公開日2023-03-01
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Release of immunomodulatory peptides at bacterial membrane interfaces as a novel strategy to fight microorganisms.
J.Biol.Chem., 299, 2023
6SY2
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Structure of the BRK domain of the SWI/SNF chromatin remodelling complex subunit BRG1 reveals a potential role in protein-protein interactions
分子名称: Transcription activator BRG1
著者Allen, M.D, Bycoft, M, Zinzalla, G.
登録日2019-09-27
公開日2020-01-22
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structure of the BRK domain of the SWI/SNF chromatin remodeling complex subunit BRG1 reveals a potential role in protein-protein interactions.
Protein Sci., 29, 2020
6BGH
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Solution NMR structure of Brd3 ET domain bound to Brg1 peptide
分子名称: Brd3_ET, Bromodomain-containing protein 3
著者Szyszka, T.N, Wai, D.C, Mackay, J.P.
登録日2017-10-28
公開日2018-03-21
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.
J.Biol.Chem., 293, 2018
2H60
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Solution Structure of Human Brg1 Bromodomain
分子名称: Probable global transcription activator SNF2L4
著者Shen, W, Xu, C, Zhang, J, Wu, J, Shi, Y.
登録日2006-05-30
公開日2007-02-13
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails
Biochemistry, 46, 2007

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