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PDB: 43 件
2JC9
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BU of 2jc9 by Molmil
Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with adenosine
分子名称: ADENOSINE, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, ...
著者Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg, S.L, Hogbom, M, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Loppnau, P, Weigelt, J, Welin, M, Nordlund, P.
登録日2006-12-21
公開日2007-01-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
5L50
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BU of 5l50 by Molmil
Crystal structure of enzyme in purine metabolism
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL
著者Hnizda, A, Pachl, P, Rezacova, P.
登録日2016-05-27
公開日2016-09-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.643 Å)
主引用文献Oligomeric interface modulation causes misregulation of purine 5 -nucleotidase in relapsed leukemia.
Bmc Biol., 14, 2016
5OPM
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BU of 5opm by Molmil
Crystal structure of D52N/R238W cN-II mutant bound to dATP and free phosphate
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, GLYCEROL, ...
著者Hnizda, A, Pachl, P, Rezacova, P.
登録日2017-08-10
公開日2018-06-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia, 32, 2018
5OPP
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BU of 5opp by Molmil
Crystal structure of S408R cN-II mutant
分子名称: BROMIDE ION, Cytosolic purine 5'-nucleotidase, GLYCEROL, ...
著者Hnizda, A, Pachl, P, Rezacova, P.
登録日2017-08-10
公開日2018-06-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia, 32, 2018
5OPK
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BU of 5opk by Molmil
Crystal structure of D52N/R367Q cN-II mutant bound to dATP and free phosphate
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, GLYCEROL, ...
著者Hnizda, A, Pachl, P, Rezacova, P.
登録日2017-08-10
公開日2018-06-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia, 32, 2018
5OPN
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BU of 5opn by Molmil
Crystal structure of R39Q cN-II mutant
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL
著者Hnizda, A, Pachl, P, Rezacova, P.
登録日2017-08-10
公開日2018-06-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia, 32, 2018
5K7Y
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BU of 5k7y by Molmil
Crystal structure of enzyme in purine metabolism
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL
著者Skerlova, J, Hnizda, A, Pachl, P, Rezacova, P.
登録日2016-05-27
公開日2016-09-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Oligomeric interface modulation causes misregulation of purine 5 -nucleotidase in relapsed leukemia.
Bmc Biol., 14, 2016
5OPL
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BU of 5opl by Molmil
Crystal structure of K25E cN-II mutant
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION
著者Kugler, M, Hnizda, A, Pachl, P, Rezacova, P.
登録日2017-08-10
公開日2018-06-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia, 32, 2018
6DDY
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BU of 6ddy by Molmil
Crystal structure of the double mutant (D52N/K359Q) of NT5C2-537X in the active state, Northeast Structural Genomics Target
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, PHOSPHATE ION
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L, Northeast Structural Genomics Consortium (NESG)
登録日2018-05-10
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.803 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
5L4Z
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BU of 5l4z by Molmil
Crystal structure of enzyme in purine metabolism
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL
著者Hnizda, A, Pachl, P, Rezacova, P.
登録日2016-05-27
公開日2016-09-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Oligomeric interface modulation causes misregulation of purine 5 -nucleotidase in relapsed leukemia.
Bmc Biol., 14, 2016
2XCW
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BU of 2xcw by Molmil
Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with inosine monophosphate and ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, ...
著者Wallden, K, Nordlund, P.
登録日2010-04-26
公開日2011-03-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
6DDZ
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BU of 6ddz by Molmil
Crystal structure of the double mutant (D52N/R238W) of NT5C2-537X in the active state, Northeast Structural Genomics Target
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, GLYCEROL, ...
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L, Northeast Structural Genomics Consortium (NESG)
登録日2018-05-10
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6DD3
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BU of 6dd3 by Molmil
Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, PHOSPHATE ION
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L.
登録日2018-05-09
公開日2018-07-04
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
2XJC
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BU of 2xjc by Molmil
Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with guanosine monophosphate and diadenosine tetraphosphate
分子名称: BIS(ADENOSINE)-5'-TETRAPHOSPHATE, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, ...
著者Wallden, K, Nordlund, P.
登録日2010-07-03
公開日2011-03-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
2XJD
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BU of 2xjd by Molmil
Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with inorganic phosphate and deoxyadenosine triphosphate
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, ...
著者Wallden, K, Nordlund, P.
登録日2010-07-04
公開日2011-04-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II.
J.Mol.Biol., 408, 2011
5OPO
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BU of 5opo by Molmil
Crystal structure of R238G cN-II mutant
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION
著者Hnizda, A, Pachl, P, Rezacova, P.
登録日2017-08-10
公開日2018-06-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia, 32, 2018
6DE0
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BU of 6de0 by Molmil
Crystal structure of the single mutant (D52N) of NT5C2-Q523X in the active state
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, PHOSPHATE ION
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L.
登録日2018-05-10
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6DE2
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BU of 6de2 by Molmil
Crystal structure of the double mutant (D52N/L375F) of the full-length NT5C2 in the active state
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, ...
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L.
登録日2018-05-10
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
2XJF
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BU of 2xjf by Molmil
Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II with a covalently modified Asn52
分子名称: (2R)-2,3-diphosphoglyceric acid, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL
著者Wallden, K, Nordlund, P.
登録日2010-07-04
公開日2011-03-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
2JCM
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BU of 2jcm by Molmil
Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with beryllium trifluoride
分子名称: CYTOSOLIC PURINE 5'-NUCLEOTIDASE, MAGNESIUM ION, SULFATE ION, ...
著者Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Loppnau, P, Weigelt, J, Welin, M, Nordlund, P.
登録日2006-12-27
公開日2007-01-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
6DE1
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BU of 6de1 by Molmil
Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the active state
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, PHOSPHATE ION
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L.
登録日2018-05-10
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.151 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
2J2C
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BU of 2j2c by Molmil
Crystal structure of Human Cytosolic 5'-Nucleotidase II (NT5C2, cN-II)
分子名称: CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, MAGNESIUM ION, ...
著者Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Karlberg, T, Kotenyova, T, Loppnau, P, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Welin, M, Nordlund, P.
登録日2006-08-16
公開日2006-09-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
6FIW
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BU of 6fiw by Molmil
Human cytosolic 5'-nucleotidase II co-crystallized with 10mM Sodium ((4-(3'-((7H-purin-6-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)-1H-imidazol-1-yl) methyl) phosphonate
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION, ...
著者Aghajari, N, Preeti, P.
登録日2018-01-19
公開日2019-01-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Lead optimization and biological evaluation of fragment-based cN-II inhibitors.
Eur J Med Chem, 168, 2019
6DDL
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BU of 6ddl by Molmil
Crystal structure of the single mutant (D52N) of NT5C2-Q523X in the basal state
分子名称: Cytosolic purine 5'-nucleotidase, PHOSPHATE ION
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L.
登録日2018-05-10
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6FIS
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BU of 6fis by Molmil
Human cytosolic 5'-nucleotidase II soaked with 10mM 7-Benzyloxymethyl-7H-adenine
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION, ...
著者Aghajari, N, Preeti, P.
登録日2018-01-19
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Lead optimization and biological evaluation of fragment-based cN-II inhibitors.
Eur J Med Chem, 168, 2019

 

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