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PDB: 73 件
6A3C
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BU of 6a3c by Molmil
MVM NES mutant Nm12 in complex with CRM1-Ran-RanBP1
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ...
著者Sun, Q, Li, Y.
登録日2018-06-15
公開日2019-06-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.
Int J Nanomedicine, 16, 2021
6X2M
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BU of 6x2m by Molmil
Crystal Structure of unliganded CRM1-Ran-RanBP1
分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
著者Baumhardt, J.M.
登録日2020-05-20
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.351 Å)
主引用文献Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Mol.Biol.Cell, 31, 2020
5YRO
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BU of 5yro by Molmil
RanL182A in complex with RanBP1-CRM1
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1,Exportin-1, ...
著者Sun, Q, Zhang, Y.
登録日2017-11-09
公開日2018-11-21
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.396 Å)
主引用文献RanL182A in complex with RanBP1-CRM1
To Be Published
6X2P
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BU of 6x2p by Molmil
Crystal Structure of the Mek1NES peptide bound to CRM1
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ...
著者Baumhardt, J.M.
登録日2020-05-20
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Mol.Biol.Cell, 31, 2020
5UWS
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BU of 5uws by Molmil
Crystal Structure of X11L2 NES Peptide in complex with CRM1-Ran-RanBP1
分子名称: Amyloid beta A4 precursor protein-binding family A member 3, Exportin-1,Exportin-1, GLYCEROL, ...
著者Fung, H.Y.J, Chook, Y.M.
登録日2017-02-21
公開日2017-03-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Elife, 6, 2017
6XJT
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BU of 6xjt by Molmil
Crystal Structure of KPT-8602 bound to CRM1 (537-DLTVK-541 to GLCEQ)
分子名称: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ...
著者Baumhardt, J.M, Chook, Y.M.
登録日2020-06-24
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
6X2X
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BU of 6x2x by Molmil
Crystal Structure of Mek1NES peptide bound to CRM1(E571K)
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ...
著者Baumhardt, J.M.
登録日2020-05-21
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.458 Å)
主引用文献Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Mol.Biol.Cell, 31, 2020
6X2S
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BU of 6x2s by Molmil
Crystal Structure of Mek1(NQ)NES peptide bound to CRM
分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ...
著者Baumhardt, J.M.
登録日2020-05-20
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.496 Å)
主引用文献Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Mol.Biol.Cell, 31, 2020
6LQ9
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BU of 6lq9 by Molmil
S109 in complex with CRM1-Ran-RanBP1
分子名称: (3~{R},4~{S})-1-[[6-chloranyl-5-(trifluoromethyl)pyridin-2-yl]amino]-3,4-dimethyl-pyrrolidine-2,5-dione, CHLORIDE ION, Exportin-1, ...
著者Sun, Q, Lei, Y.
登録日2020-01-13
公開日2021-06-23
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1.
J.Med.Chem., 64, 2021
5JLJ
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BU of 5jlj by Molmil
Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1
分子名称: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, CHLORIDE ION, Exportin-1, ...
著者Fung, H.Y, Chook, Y.M.
登録日2016-04-27
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.
Leukemia, 30, 2016
6KFT
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BU of 6kft by Molmil
MVM NS2 mutant Nm42 in complex with CRM1-Ran-RanBP1
分子名称: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ...
著者Sun, Q, Li, Y.
登録日2019-07-08
公開日2020-07-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.
Int J Nanomedicine, 16, 2021
6A3B
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BU of 6a3b by Molmil
MVM NES mutant Nm13 in complex with CRM1-Ran-RanBP1
分子名称: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ...
著者Sun, Q, Li, Y.
登録日2018-06-15
公開日2019-06-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.
Int J Nanomedicine, 16, 2021
5DH9
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BU of 5dh9 by Molmil
Crystal Structure of PKI NES Flip Mutant Peptide in complex with CRM1-Ran-RanBP1
分子名称: Engineered Nuclear Export Signal Peptide (PKINES-Flip3 mutant), Exportin-1, GLYCEROL, ...
著者Fung, H.Y, Chook, Y.M.
登録日2015-08-30
公開日2015-09-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural determinants of nuclear export signal orientation in binding to exportin CRM1.
Elife, 4, 2015
6X2O
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BU of 6x2o by Molmil
Crystal Structure of unliganded CRM1(E571K)-Ran-RanBP1
分子名称: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ...
著者Baumhardt, J.M.
登録日2020-05-20
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.551 Å)
主引用文献Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Mol.Biol.Cell, 31, 2020
5ZPU
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BU of 5zpu by Molmil
LFS829 in complex with CRM1-Ran-RanBP1
分子名称: (Z)-{[(3E)-4-{(R)-[3,5-bis(trifluoromethyl)phenyl]sulfinyl}but-3-en-1-yl]imino}methanethiol, CHLORIDE ION, Exportin-1,Exportin-1, ...
著者Sun, Q, Lei, Y.
登録日2018-04-16
公開日2019-04-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献To be published
To Be Published
6A38
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BU of 6a38 by Molmil
MVM NS2 NES in complex with CRM1-Ran-RanBP1
分子名称: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ...
著者Sun, Q, Li, Y.
登録日2018-06-15
公開日2019-06-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.
Int J Nanomedicine, 16, 2021
6A3E
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BU of 6a3e by Molmil
MVM NES mutant Nm15 in complex with CRM1-Ran-RanBP1
分子名称: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Sun, Q, Li, Y.
登録日2018-06-15
公開日2019-06-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.
Int J Nanomedicine, 16, 2021
4HB3
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BU of 4hb3 by Molmil
Crystal structure of CRM1(T539S)-Ran-RanBP1 with weakly bound unmodeled Leptomycin B
分子名称: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ...
著者Sun, Q, Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
6XJP
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BU of 6xjp by Molmil
Crystal Structure of KPT-185 bound to CRM1 (537-DLTVK-541 to GLCEQ)
分子名称: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ...
著者Baumhardt, J.M, Chook, Y.M.
登録日2020-06-24
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.802 Å)
主引用文献Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
6X2V
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BU of 6x2v by Molmil
Crystal Structure of PKI(DE)NES peptide bound to CRM1
分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
著者Baumhardt, J.M.
登録日2020-05-21
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.822 Å)
主引用文献Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Mol.Biol.Cell, 31, 2020
6M6X
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BU of 6m6x by Molmil
Oridonin in complex with CRM1#-Ran-RanBP1
分子名称: (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, 1,2-ETHANEDIOL, CHLORIDE ION, ...
著者Sun, Q, Lei, Y.
登録日2020-03-16
公開日2021-03-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.
J.Nat.Prod., 84, 2021
5DHA
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BU of 5dha by Molmil
Crystal Structure of CPEB4 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1
分子名称: Engineered Nuclear Export Signal Peptide (CPEB4 NES reverse mutant), Exportin-1, GLYCEROL, ...
著者Fung, H.Y, Chook, Y.M.
登録日2015-08-30
公開日2015-09-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural determinants of nuclear export signal orientation in binding to exportin CRM1.
Elife, 4, 2015
6X2W
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BU of 6x2w by Molmil
Crystal Structure of PKINES peptide bound to CRM1(E571K)
分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
著者Baumhardt, J.M.
登録日2020-05-21
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.001 Å)
主引用文献Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Mol.Biol.Cell, 31, 2020
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