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PDB: 132 件

8H05
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Minor polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient
分子名称: Alpha-synuclein
著者Fan, Y, Sun, Y.P, Wang, J, Liu, C.
登録日2022-09-28
公開日2022-11-30
最終更新日2023-01-25
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
8RRR
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Alpha-synuclein amyloid fibril
分子名称: Alpha-synuclein
著者Saibil, H.R, Monistrol, J.
登録日2024-01-23
公開日2024-02-28
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly
Biorxiv, 2024
6H6B
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Structure of alpha-synuclein fibrils
分子名称: Alpha-synuclein
著者Guerrero-Ferreira, R, Taylor, N.M.I, Mona, D, Ringler, P, Lauer, M.E, Riek, R, Britschgi, M, Stahlberg, H.
登録日2018-07-26
公開日2018-08-08
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structure of alpha-synuclein fibrils.
Elife, 7, 2018
6OSM
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Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-103
分子名称: Alpha-synuclein
著者Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L.
登録日2019-05-01
公開日2019-09-25
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations.
J.Mol.Biol., 431, 2019
7V49
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Type 4 alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient
分子名称: Alpha-synuclein
著者Fan, Y, Sun, Y.P, Wang, J, Liu, C.
登録日2021-08-12
公開日2022-08-17
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
7WNZ
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CryoEM structure of human alpha-synuclein A53T fibril
分子名称: Alpha-synuclein
著者Wu, K.-P, Huang, J.Y.-C.
登録日2022-01-20
公開日2023-01-25
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Calcium abolishes intramolecular long-range contacts and promotes hereditary alpha-synuclein A53T aggregation
To Be Published
6SST
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BU of 6sst by Molmil
cryo-em structure of alpha-synuclein fibril polymorph 2B
分子名称: Alpha-synuclein
著者Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H.
登録日2019-09-09
公開日2019-12-18
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.
Elife, 8, 2019
8PIX
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BU of 8pix by Molmil
Cryo EM structure of the type 3C polymorph of alpha-synuclein at low pH.
分子名称: Alpha-synuclein
著者Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
登録日2023-06-22
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation
Elife, 2023
7NCG
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Type 2A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2
分子名称: Alpha-synuclein
著者Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
登録日2021-01-28
公開日2021-02-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy.
Febs Open Bio, 11, 2021
6RTB
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BU of 6rtb by Molmil
cryo-em structure of alpha-synuclein fibril polymorph 2B
分子名称: Alpha-synuclein
著者Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H.
登録日2019-05-22
公開日2019-06-26
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.
Elife, 8, 2019
7NCA
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Type 1A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2
分子名称: Alpha-synuclein
著者Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
登録日2021-01-28
公開日2021-02-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy.
Febs Open Bio, 11, 2021
6LRQ
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BU of 6lrq by Molmil
Cryo-EM structure of A53T alpha-synuclein amyloid fibril
分子名称: Alpha-synuclein
著者Sun, Y.P, Zhao, K, Liu, C.
登録日2020-01-16
公開日2020-04-08
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献Cryo-EM structure of full-length alpha-synuclein amyloid fibril with Parkinson's disease familial A53T mutation.
Cell Res., 30, 2020
8CYV
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CryoEM structures of amplified alpha-synuclein fibril class B mixed type I/II with extended core from DLB case II
分子名称: Alpha-synuclein
著者Zhou, Y, Sokratian, A, Xu, E, Viverette, E, Dillard, L, Yuan, Y, Li, J.Y, Matarangas, A, Bouvette, J, Borgnia, M, Bartesaghi, A, West, A.
登録日2022-05-24
公開日2023-05-31
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural and functional landscape of alpha-synuclein fibril assemblies amplified from cerebrospinal fluid
To Be Published
7V4D
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Heparin-remodelled alpha-synuclein fibrils
分子名称: Alpha-synuclein
著者Tao, Y.Q, Sun, Y.P, Xia, W.C, Zhao, Q.Y, Liu, C, Li, D.
登録日2021-08-12
公開日2022-08-17
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Heparin-remodelled alpha-synuclein fibrils
To Be Published
6CU7
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Alpha Synuclein fibril formed by full length protein - Rod Polymorph
分子名称: Alpha-synuclein
著者Li, B, Hatami, A, Ge, P, Murray, K.A, Sheth, P, Zhang, M, Nair, G, Sawaya, M.R, Zhu, C, Broad, M, Shin, W.S, Ye, S, John, V, Eisenberg, D.S, Zhou, Z.H, Jiang, L.
登録日2018-03-23
公開日2018-09-12
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel.
Nat Commun, 9, 2018
7NCI
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BU of 7nci by Molmil
Type 2B alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1
分子名称: Alpha-synuclein
著者Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
登録日2021-01-28
公開日2021-02-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.55 Å)
主引用文献Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy.
Febs Open Bio, 11, 2021
6PES
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BU of 6pes by Molmil
Cryo-EM structure of alpha-synuclein H50Q Wide Fibril
分子名称: Alpha-synuclein
著者Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S.
登録日2019-06-20
公開日2019-11-27
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs.
Nat.Struct.Mol.Biol., 26, 2019
6CU8
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BU of 6cu8 by Molmil
Alpha Synuclein fibril formed by full length protein - Twister Polymorph
分子名称: Alpha-synuclein
著者Li, B, Hatami, A, Ge, P, Murray, K.A, Sheth, P, Zhang, M, Nair, G, Sawaya, M.R, Zhu, C, Broad, M, Shin, W.S, Ye, S, John, V, Eisenberg, D.S, Zhou, Z.H, Jiang, L.
登録日2018-03-23
公開日2018-09-12
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel.
Nat Commun, 9, 2018
7C1D
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BU of 7c1d by Molmil
Cryo-EM structure of the hE46K cross-seeded hWT alpha-synuclein fibril
分子名称: Alpha-synuclein
著者Sun, Y.P, Zhao, K, Liu, C.
登録日2020-05-03
公開日2021-05-05
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Wild-type alpha-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding.
Proc.Natl.Acad.Sci.USA, 118, 2021
7NCH
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BU of 7nch by Molmil
Type 1B alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1
分子名称: Alpha-synuclein
著者Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
登録日2021-01-28
公開日2021-02-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.84 Å)
主引用文献Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy.
Febs Open Bio, 11, 2021
7L7H
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BU of 7l7h by Molmil
Alpha-synuclein fibrils
分子名称: Alpha-synuclein
著者Hojjatian, A, Dasari, A.
登録日2020-12-28
公開日2022-01-12
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Distinct cryo-EM Structure of Alpha-synuclein Filaments derived by Tau
To Be Published
8CYR
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BU of 8cyr by Molmil
Alpha-synuclein fibril from spontaneous control
分子名称: Alpha-synuclein
著者Zhou, Y, Sokratian, A, Xu, E, Viverette, E, Dillard, L, Yuan, Y, Li, J.Y, Matarangas, A, Bouvette, J, Borgnia, M, Bartesaghi, A, West, A.
登録日2022-05-24
公開日2023-05-31
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Distinct cryo-EM structures and functions of alpha-synuclein fibrils amplified from cerebrospinal fluid
To Be Published
7NCJ
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BU of 7ncj by Molmil
Type 2AB alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1
分子名称: Alpha-synuclein
著者Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
登録日2021-01-28
公開日2021-02-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (4.23 Å)
主引用文献Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy.
Febs Open Bio, 11, 2021
8GF7
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Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein
著者Balana, J.A, Nguyen, A.B, Saelices, L, Pratt, R.M.
登録日2023-03-07
公開日2023-11-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献O-GlcNAc forces an alpha-synuclein amyloid strain with notably diminished seeding and pathology.
Nat.Chem.Biol., 20, 2024
2KKW
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SLAS-micelle bound alpha-synuclein
分子名称: Alpha-synuclein
著者Rao, J, Jao, C.C, Hegde, B, Langen, R, Ulmer, T.S.
登録日2009-06-29
公開日2010-06-16
最終更新日2024-05-01
実験手法EPR, SOLUTION NMR
主引用文献A combinatorial NMR and EPR approach for evaluating the structural ensemble of partially folded proteins.
J.Am.Chem.Soc., 132, 2010

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