6UFR
 
 | | Structure of recombinantly assembled E46K alpha-synuclein fibrils | | 分子名称: | Alpha-synuclein | | 著者 | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Li, B, Jiang, L. | | 登録日 | 2019-09-24 | | 公開日 | 2020-02-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8JEY
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6XYO
 | | Multiple system atrophy Type I alpha-synuclein filament | | 分子名称: | Alpha-synuclein | | 著者 | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | | 登録日 | 2020-01-30 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
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7YNL
 | | EB-bound alpha-synuclein fibrils | | 分子名称: | 4-azanyl-6-[[4-[4-[(~{E})-(8-azanyl-1-oxidanyl-5,7-disulfo-naphthalen-2-yl)diazenyl]-3-methyl-phenyl]-2-methyl-phenyl]diazenyl]-5-oxidanyl-naphthalene-1,3-disulfonic acid, Alpha-synuclein | | 著者 | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | | 登録日 | 2022-07-31 | | 公開日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | EB-bound alpha-synuclein fibrils
To Be Published
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7XO3
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7WMM
 | | alpha-synuclein fibril-F0502B complex | | 分子名称: | 2-bromanyl-4-[(~{E})-2-[6-[2-(2-fluoranylethoxy)ethyl-methyl-amino]-5-methyl-1,3-benzothiazol-2-yl]ethenyl]phenol, Alpha-synuclein | | 著者 | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | | 登録日 | 2022-01-15 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | alpha-synuclein fibril-F0502B complex
To Be Published
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8A4L
 | | Lipidic alpha-synuclein fibril - polymorph L2A | | 分子名称: | Alpha-synuclein | | 著者 | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | | 登録日 | 2022-06-12 | | 公開日 | 2022-08-17 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | The 3D structure of lipidic fibrils of alpha-synuclein.
Nat Commun, 13, 2022
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8CE7
 | | Type1 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein | | 分子名称: | Alpha-synuclein | | 著者 | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | | 登録日 | 2023-02-01 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
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8CEB
 | | Type2 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein | | 分子名称: | Alpha-synuclein | | 著者 | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Sew, P.C, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | | 登録日 | 2023-02-01 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
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7WO0
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7XJX
 | | The cryo-EM structure of Fe3+ induced alpha-syn fibril. | | 分子名称: | Alpha-synuclein | | 著者 | Zhao, Q.Y, Tao, Y.Q, Zhao, K, Tao, Y.Q, Li, D. | | 登録日 | 2022-04-18 | | 公開日 | 2023-01-18 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural Insights of Fe3+ Induced alpha-synuclein Fibrillation in Parkinson' Disease
J.Mol.Biol., 435, 2023
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8AEX
 | | Lipidic alpha-synuclein fibril - polymorph L3A | | 分子名称: | Alpha-synuclein | | 著者 | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | | 登録日 | 2022-07-14 | | 公開日 | 2022-10-12 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | | 主引用文献 | The 3D structure of lipidic fibrils of alpha-synuclein.
Nat Commun, 13, 2022
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8H03
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7YNQ
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7YNP
 | | BF227-bound alpha-synuclein fibrils | | 分子名称: | 5-[(~{E})-2-(6-methoxy-1,3-benzoxazol-2-yl)ethenyl]-~{N},~{N}-dimethyl-1,3-thiazol-2-amine, Alpha-synuclein | | 著者 | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | | 登録日 | 2022-07-31 | | 公開日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | BF227-bound alpha-synuclein fibrils
To Be Published
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7YNO
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6OSJ
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7V47
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7YK2
 | | Cryo-EM structure of Apo-alpha-syn fibril | | 分子名称: | Alpha-synuclein | | 著者 | Xu, Q.H, Xia, W.C, Tao, Y.Q, Liu, C. | | 登録日 | 2022-07-21 | | 公開日 | 2023-03-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Conformational Dynamics of an alpha-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy.
J.Am.Chem.Soc., 145, 2023
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7YK8
 | | Cryo-EM structure of dLAG3-alpha-syn fibril | | 分子名称: | Alpha-synuclein | | 著者 | Xu, Q.H, Xia, W.C, Tao, Y.Q, Liu, C. | | 登録日 | 2022-07-22 | | 公開日 | 2023-03-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Conformational Dynamics of an alpha-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy.
J.Am.Chem.Soc., 145, 2023
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8CZ0
 | | CryoEM structure of amplified alpha-synuclein fibril class B type I with extended core from DLB case VII | | 分子名称: | Alpha-synuclein | | 著者 | Zhou, Y, Sokratian, A, Xu, E, Viverette, E, Dillard, L, Yuan, Y, Li, J.Y, Matarangas, A, Bouvette, J, Borgnia, M, Bartesaghi, A, West, A. | | 登録日 | 2022-05-24 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural and functional landscape of alpha-synuclein fibril assemblies amplified from cerebrospinal fluid
To Be Published
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7YNM
 | | ThT-bound alpha-synuclein fibrils conformation 1 | | 分子名称: | 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, Alpha-synuclein | | 著者 | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | | 登録日 | 2022-07-31 | | 公開日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | ThT-bound alpha-synuclein fibrils conformation 1
To Be Published
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7YNR
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7YNN
 | | ThT-bound alpha-synuclein fibrils conformation 2 | | 分子名称: | 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, Alpha-synuclein | | 著者 | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | | 登録日 | 2022-07-31 | | 公開日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | ThT-bound alpha-synuclein fibrils conformation 2
To Be Published
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8ADW
 | | Lipidic alpha-synuclein fibril - polymorph L1C | | 分子名称: | Alpha-synuclein | | 著者 | Frieg, B, Antonschmidt, L, Dienemann, C, Geraets, J.A, Najbauer, E.E, Matthes, D, de Groot, B.L, Andreas, L.B, Becker, S, Griesinger, C, Schroeder, G.F. | | 登録日 | 2022-07-11 | | 公開日 | 2022-10-12 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | The 3D structure of lipidic fibrils of alpha-synuclein.
Nat Commun, 13, 2022
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