7XO3

Type 1C alpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-4) Parkinson's disease patient

Summary for 7XO3

• Entry DOI: 10.2210/pdb7xo3/pdb
• EMDB information: 33335
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: amyloid fibril, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 86856.65

Authors

Fan, Y.,Sun, Y.P.,Wang, J.,Liu, C. (deposition date: 2022-04-30, release date: 2022-11-30, Last modification date: 2023-01-25)

• Primary citation: Fan, Y.,Sun, Y.,Yu, W.,Tao, Y.,Xia, W.,Liu, Y.,Zhao, Q.,Tang, Y.,Sun, Y.,Liu, F.,Cao, Q.,Wu, J.,Liu, C.,Wang, J.,Li, D.; Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.; Structure, 31:78-, 2023; PubMed: 36513068; DOI: 10.1016/j.str.2022.11.013

Experimental method

ELECTRON MICROSCOPY (2.6 Å)