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PDB: 40 件
7ZK5
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BU of 7zk5 by Molmil
ABCB1 L335C mutant (mABCB1) in the outward facing state bound to AAC
分子名称: (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent translocase ABCB1, ...
著者Parey, K, Januliene, D, Gewering, T, Moeller, A.
登録日2022-04-12
公開日2023-04-26
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Tracing the substrate translocation mechanism in P-glycoprotein.
Elife, 12, 2024
7ZK4
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BU of 7zk4 by Molmil
The ABCB1 L335C mutant (mABCB1) in the outward facing state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent translocase ABCB1, CHOLESTEROL HEMISUCCINATE, ...
著者Parey, K, Januliene, D, Gewering, T, Moeller, A.
登録日2022-04-12
公開日2023-04-26
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Tracing the substrate translocation mechanism in P-glycoprotein.
Elife, 12, 2024
7ZKA
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BU of 7zka by Molmil
ABCB1 V978C mutant (mABCB1) in the outward facing state bound to AAC
分子名称: (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent translocase ABCB1, ...
著者Parey, K, Januliene, D, Gewering, T, Urbatsch, I, Zhang, Q, Moeller, A.
登録日2022-04-12
公開日2023-04-26
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Tracing the substrate translocation mechanism in P-glycoprotein.
Elife, 12, 2024
8AVY
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BU of 8avy by Molmil
The ABCB1 L335C mutant (mABCB1) in the Apo state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent translocase ABCB1, CHOLESTEROL HEMISUCCINATE, ...
著者Parey, K, Januliene, D, Gewering, T, Moeller, A.
登録日2022-08-27
公開日2023-09-06
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Tracing the substrate translocation mechanism in P-glycoprotein.
Elife, 12, 2024
7ZK8
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BU of 7zk8 by Molmil
ABCB1 L971C mutant (mABCB1) in the outward facing state bound to AAC
分子名称: (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent translocase ABCB1, ...
著者Parey, K, Januliene, D, Gewering, T, Moeller, A.
登録日2022-04-12
公開日2023-04-26
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Tracing the substrate translocation mechanism in P-glycoprotein.
Elife, 12, 2024
7ZK6
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BU of 7zk6 by Molmil
ABCB1 L335C mutant (mABCB1) in the outward facing state bound to 2 molecules of AAC
分子名称: (4S,11S,18S)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Parey, K, Januliene, D, Gewering, T, Moeller, A.
登録日2022-04-12
公開日2023-04-26
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Tracing the substrate translocation mechanism in P-glycoprotein.
Elife, 12, 2024
5KO2
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BU of 5ko2 by Molmil
Mouse pgp 34 linker deleted mutant Hg derivative
分子名称: MERCURY (II) ION, Multidrug resistance protein 1A
著者Xia, D, Esser, L, Zhou, F.
登録日2016-06-29
公開日2016-11-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
J. Biol. Chem., 292, 2017
5KPD
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BU of 5kpd by Molmil
Mouse pgp 34 linker deleted double EQ mutant
分子名称: Multidrug resistance protein 1A
著者Xia, D, Esser, L, Zhou, F.
登録日2016-07-03
公開日2016-11-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
J. Biol. Chem., 292, 2017
4Q9H
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BU of 4q9h by Molmil
P-glycoprotein at 3.4 A resolution
分子名称: Multidrug resistance protein 1A
著者McGrath, A.P, Szewczyk, P, Chang, G.
登録日2014-05-01
公開日2015-03-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71, 2015
5KPJ
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BU of 5kpj by Molmil
Mouse pgp methylated protein
分子名称: Multidrug resistance protein 1A
著者Xia, D, Esser, L, Zhou, F.
登録日2016-07-04
公開日2016-11-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
J. Biol. Chem., 292, 2017
4XWK
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BU of 4xwk by Molmil
P-glycoprotein co-crystallized with BDE-100
分子名称: 2,4-dibromophenyl 2,4,6-tribromophenyl ether, Multidrug resistance protein 1A
著者McGrath, A.P, Rees, S.D, Chang, G.
登録日2015-01-28
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure.
Sci Adv, 2, 2016
4Q9J
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BU of 4q9j by Molmil
P-glycoprotein cocrystallised with QZ-Val
分子名称: Multidrug resistance protein 1A, N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC ACID
著者McGrath, A.P, Szewczyk, P, Chang, G.
登録日2014-05-01
公開日2015-03-04
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71, 2015
4Q9I
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BU of 4q9i by Molmil
P-glycoprotein cocrystallised with QZ-Ala
分子名称: (30F)A(30F)A(30F)A Peptide, Multidrug resistance protein 1A
著者McGrath, A.P, Szewczyk, P, Chang, G.
登録日2014-05-01
公開日2015-03-04
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (3.781 Å)
主引用文献Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71, 2015
4M1M
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BU of 4m1m by Molmil
Corrected Structure of Mouse P-glycoprotein
分子名称: MERCURY (II) ION, Multidrug resistance protein 1A
著者Li, J, Jaimes, K.F, Aller, S.G.
登録日2013-08-03
公開日2013-11-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Refined structures of mouse P-glycoprotein.
Protein Sci., 23, 2014
4Q9K
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BU of 4q9k by Molmil
P-glycoprotein cocrystallised with QZ-Leu
分子名称: (30F)L(30F)L(30F)L Peptide, Multidrug resistance protein 1A
著者McGrath, A.P, Szewczyk, P, Chang, G.
登録日2014-05-01
公開日2015-03-04
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71, 2015
8PEE
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BU of 8pee by Molmil
ABCB1 L335C mutant (mABCB1) in the inward facing state bound to AAC
分子名称: (4S,11S,18S)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, (4~{S},11~{S},18~{S})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, ATP-dependent translocase ABCB1, ...
著者Parey, K, Januliene, D, Gewering, T, Moeller, A.
登録日2023-06-13
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Tracing the substrate translocation mechanism in P-glycoprotein.
Elife, 12, 2024
4LSG
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BU of 4lsg by Molmil
Structure of Mouse P-Glycoprotein
分子名称: MERCURY (II) ION, Multidrug resistance protein 1A
著者Chang, G, Szewczyk, P.
登録日2013-07-22
公開日2013-07-31
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献

4Q9L
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BU of 4q9l by Molmil
P-glycoprotein cocrystallised with QZ-Phe
分子名称: (30F)F(30F)F(30F)F Peptide, Multidrug resistance protein 1A
著者McGrath, A.P, Szewczyk, P, Chang, G.
登録日2014-05-01
公開日2015-03-04
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Acta Crystallogr.,Sect.D, 71, 2015
3G5U
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BU of 3g5u by Molmil
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
分子名称: MERCURY (II) ION, Multidrug resistance protein 1a
著者Aller, S.G, Yu, J, Ward, A, Weng, Y, Chittaboina, S, Zhuo, R, Harrell, P.M, Trinh, Y.T, Zhang, Q, Urbatsch, I.L, Chang, G.
登録日2009-02-05
公開日2009-03-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science, 323, 2009
4KSB
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BU of 4ksb by Molmil
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
分子名称: Multidrug resistance protein 1A
著者Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G.
登録日2013-05-17
公開日2013-07-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.8001 Å)
主引用文献Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
5KOY
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BU of 5koy by Molmil
Mouse pgp 34 linker deleted bound with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Multidrug resistance protein 1A
著者Xia, D, Esser, L, Zhou, F.
登録日2016-07-01
公開日2016-12-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.85 Å)
主引用文献Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
J. Biol. Chem., 292, 2017
6UJP
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BU of 6ujp by Molmil
P-glycoprotein mutant-F979A and C952A-with BDE100
分子名称: 2,4-dibromophenyl 2,4,6-tribromophenyl ether, ATP-dependent translocase ABCB1
著者Aller, S.G, Le, C.A.
登録日2019-10-03
公開日2020-05-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.98 Å)
主引用文献Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein.
Iucrj, 7, 2020
6UJN
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BU of 6ujn by Molmil
P-glycoprotein mutant-C952A-with BDE100
分子名称: 2,4-dibromophenyl 2,4,6-tribromophenyl ether, ATP-dependent translocase ABCB1
著者Aller, S.G, Le, C.A.
登録日2019-10-03
公開日2020-05-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.98 Å)
主引用文献Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein.
Iucrj, 7, 2020
4KSC
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BU of 4ksc by Molmil
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
分子名称: Multidrug resistance protein 1A
著者Ward, A, Szewczyk, P, Grimard, V, Lee, C.-W, Martinez, L, Doshi, R, Caya, A, Villaluz, M, Pardon, E, Cregger, C, Swartz, D.J, Falson, P, Urbatsch, I, Govaerts, C, Steyaert, J, Chang, G.
登録日2013-05-17
公開日2013-07-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
5KPI
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BU of 5kpi by Molmil
Mouse native PGP
分子名称: Multidrug resistance protein 1A
著者Xia, D, Esser, L, Zhou, F.
登録日2016-07-04
公開日2016-11-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.01 Å)
主引用文献Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
J. Biol. Chem., 292, 2017

 

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