7KLW
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![BU of 7klw by Molmil](/molmil-images/mine/7klw) | Crystal structure of synthetic nanobody (Sb45+Sb68) complexes with SARS-CoV-2 receptor binding domain | 分子名称: | SB45, Synthetic Nanobody, SB68, ... | 著者 | Jiang, J, Ahmad, J, Natarajan, K, Boyd, L.F, Margulies, D.H. | 登録日 | 2020-11-01 | 公開日 | 2021-02-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of synthetic nanobody-SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction. J.Biol.Chem., 297, 2021
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7LY0
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![BU of 7ly0 by Molmil](/molmil-images/mine/7ly0) | |
7LXZ
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![BU of 7lxz by Molmil](/molmil-images/mine/7lxz) | |
8GON
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![BU of 8gon by Molmil](/molmil-images/mine/8gon) | |
8XM5
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![BU of 8xm5 by Molmil](/molmil-images/mine/8xm5) | Cryo-EM structure of SARS-CoV-2 Omicron EG.5 spike protein(6P), RBD-closed state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F. | 登録日 | 2023-12-27 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Structural basis of receptor binding and immune escape for SARS-CoV-2 Omicron BA.2.86, EG.5, EG.5.1 and HV.1 sub-variants To Be Published
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7SXZ
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![BU of 7sxz by Molmil](/molmil-images/mine/7sxz) | Cryo-EM structure of the SARS-CoV-2 D614G,L452R mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | 著者 | Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Kim, A, Li, W, Dimitrov, D.S, Subramaniam, S. | 登録日 | 2021-11-24 | 公開日 | 2021-12-29 | 最終更新日 | 2022-01-05 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding. Cell Rep, 37, 2021
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7BEP
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![BU of 7bep by Molmil](/molmil-images/mine/7bep) | Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-384 and S309 Fabs | 分子名称: | CHLORIDE ION, COVOX-384 heavy chain, COVOX-384 light chain, ... | 著者 | Zhou, D, Zhao, Y, Ren, J, Stuart, D. | 登録日 | 2020-12-24 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | The antigenic anatomy of SARS-CoV-2 receptor binding domain. Cell, 184, 2021
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7B18
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![BU of 7b18 by Molmil](/molmil-images/mine/7b18) | SARS-CoV-spike bound to two neutralising nanobodies | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody against SARS-CoV-2 VHH E, ... | 著者 | Hallberg, B.M, Das, H. | 登録日 | 2020-11-24 | 公開日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science, 371, 2021
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8WLO
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![BU of 8wlo by Molmil](/molmil-images/mine/8wlo) | Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with hippopotamus ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | 著者 | Han, P, Yang, R.R, Li, S.H. | 登録日 | 2023-09-30 | 公開日 | 2024-03-27 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Molecular basis of hippopotamus ACE2 binding to SARS-CoV-2. J.Virol., 98, 2024
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7XDB
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![BU of 7xdb by Molmil](/molmil-images/mine/7xdb) | Cryo-EM structure of SARS-CoV-2 Omicron Spike protein in complex with BA7208 fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BA7208 fab, ... | 著者 | Liu, Z, Liu, S, Gao, Y.Z. | 登録日 | 2022-03-26 | 公開日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5. Cell Discov, 9, 2023
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7EKG
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![BU of 7ekg by Molmil](/molmil-images/mine/7ekg) | Structure of SARS-CoV-2 Beta variant spike receptor-binding domain complexed with human ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Han, P.C, Su, C, Zhang, Y.F, Qi, J.X, Gao, G.F. | 登録日 | 2021-04-05 | 公開日 | 2021-11-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants. Nat Commun, 12, 2021
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7ZSS
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![BU of 7zss by Molmil](/molmil-images/mine/7zss) | cryo-EM structure of D614 spike in complex with de novo designed binder | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Pablo, G, Sarah, W, Alexandra, V.H, Anthony, M, Andreas, S, Zander, H, Dongchun, N, Shuguang, T, Freyr, S, Casper, G, Priscilla, T, Alexandra, T, Stephane, R, Sandrine, G, Jane, M, Aaron, P, Zepeng, X, Yan, C, Pu, H, George, G, Elisa, O, Beat, F, Didier, T, Henning, S, Michael, B, Bruno, E.C. | 登録日 | 2022-05-08 | 公開日 | 2023-03-01 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
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8XN3
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![BU of 8xn3 by Molmil](/molmil-images/mine/8xn3) | SARS-CoV-2 Omicron HV.1 RBD in complex with human ACE2 (local refinement from the spike protein) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | 著者 | Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F. | 登録日 | 2023-12-28 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Structural basis of receptor binding and immune escape for SARS-CoV-2 Omicron BA.2.86, EG.5, EG.5.1 and HV.1 sub-variants To Be Published
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7SXS
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![BU of 7sxs by Molmil](/molmil-images/mine/7sxs) | Cryo-EM structure of the SARS-CoV-2 D614G,L452R mutant spike protein ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Kim, A, Li, W, Dimitrov, D.S, Subramaniam, S. | 登録日 | 2021-11-24 | 公開日 | 2021-12-29 | 最終更新日 | 2022-01-05 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding. Cell Rep, 37, 2021
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8DLP
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![BU of 8dlp by Molmil](/molmil-images/mine/8dlp) | Cryo-EM structure of SARS-CoV-2 Gamma (P.1) spike protein in complex with human ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | 著者 | Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Subramaniam, S. | 登録日 | 2022-07-08 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization. Nat Commun, 13, 2022
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8A95
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![BU of 8a95 by Molmil](/molmil-images/mine/8a95) | SARS Cov2 Spike RBD in complex with Fab47 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab47 (Heavy chain variable domain), ... | 著者 | Hallberg, B.M, Das, H. | 登録日 | 2022-06-27 | 公開日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies. Immunity, 56, 2023
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6ZCZ
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![BU of 6zcz by Molmil](/molmil-images/mine/6zcz) | Crystal structure of receptor binding domain of SARS-CoV-2 Spike glycoprotein in ternary complex with EY6A Fab and a nanobody. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, EY6A heavy chain, ... | 著者 | Zhou, D, Zhao, Y, Fry, E.E, Ren, J, Stuart, D.I. | 登録日 | 2020-06-12 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient. Nat.Struct.Mol.Biol., 27, 2020
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7M7W
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![BU of 7m7w by Molmil](/molmil-images/mine/7m7w) | Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Monoclonal antibody S2H97 Fab heavy chain, Monoclonal antibody S2H97 Fab light chain, ... | 著者 | Snell, G, Czudnochowski, N, Croll, T.I, Nix, J.C, Corti, D, Cameroni, E, Pinto, D, Beltramello, M. | 登録日 | 2021-03-29 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape. Nature, 597, 2021
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7UL1
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![BU of 7ul1 by Molmil](/molmil-images/mine/7ul1) | Crystal structure of SARS-CoV-2 RBD in complex with the neutralizing IGHV3-53-encoded antibody EH3 isolated from a nonvaccinated pediatric patient | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of EH3, Light chain of EH3, ... | 著者 | Chen, Y, Tolbert, W.D, Pazgier, M. | 登録日 | 2022-04-03 | 公開日 | 2023-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD. Iscience, 26, 2023
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8HPV
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![BU of 8hpv by Molmil](/molmil-images/mine/8hpv) | |
7WHD
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![BU of 7whd by Molmil](/molmil-images/mine/7whd) | SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (2u1d) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Zeng, J.W, Wang, X.W, Ge, J.W, Wang, Z.Y. | 登録日 | 2021-12-30 | 公開日 | 2023-01-18 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters 1 . Emerg Microbes Infect, 12, 2023
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7MY2
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![BU of 7my2 by Molmil](/molmil-images/mine/7my2) | |
7JX3
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![BU of 7jx3 by Molmil](/molmil-images/mine/7jx3) | Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab domain of monoclonal antibody S2H14, Heavy chain of Fab domain of monoclonal antibody S304, ... | 著者 | Snell, G, Czudnochowski, N, Rosen, L.E, Nix, J.C, Corti, D, Veesler, D, Park, Y.J, Walls, A.C, Tortorici, M.A, Cameroni, E, Pinto, D, Beltramello, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2020-08-26 | 公開日 | 2020-10-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology. Cell, 183, 2020
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7F15
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![BU of 7f15 by Molmil](/molmil-images/mine/7f15) | A SARS-CoV-2 neutralizing antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody, Spike protein S1 | 著者 | Zhang, G, Li, X, Guo, Y, Wang, Y, Yuan, S. | 登録日 | 2021-06-07 | 公開日 | 2022-06-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | A SARS-CoV-2 neutralizing
antibody To Be Published
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7M71
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![BU of 7m71 by Molmil](/molmil-images/mine/7m71) | SARS-CoV-2 Spike:5A6 Fab complex I focused refinement | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 5A6 Fab heavy chain, Antibody 5A6 Fab light chain, ... | 著者 | Asarnow, D, Cheng, Y. | 登録日 | 2021-03-26 | 公開日 | 2021-05-26 | 最終更新日 | 2021-06-23 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia. Cell, 184, 2021
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