6XCE
 
 | |
5V8P
 | |
4KTX
 | | Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S mutant with covalent inhibitor that modifies Cys-165 causing disorder in 167-174 stretch | | 分子名称: | Botulinum neurotoxin A light chain, GLYCEROL, Peptide inhibitor MPT-DPP-ARG-G-LEU-NH2, ... | | 著者 | Stura, E.A, Vera, L, Guitot, K, Dive, V. | | 登録日 | 2013-05-21 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A
To be Published
|
|
2W2D
 | | Crystal Structure of a Catalytically Active, Non-toxic Endopeptidase Derivative of Clostridium botulinum Toxin A | | 分子名称: | ACETATE ION, BOTULINUM NEUROTOXIN A HEAVY CHAIN, BOTULINUM NEUROTOXIN A LIGHT CHAIN, ... | | 著者 | Masuyer, G, Thiyagarajan, N, James, P.L, Marks, P.M.H, Chaddock, J.A, Acharya, K.R. | | 登録日 | 2008-10-29 | | 公開日 | 2009-03-24 | | 最終更新日 | 2022-05-04 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Crystal Structure of a Catalytically Active, Non-Toxic Endopeptidase Derivative of Clostridium Botulinum Toxin A.
Biochem.Biophys.Res.Commun., 381, 2009
|
|
5VGV
 | |
5TPB
 | |
3K3Q
 | | Crystal Structure of a Llama Antibody complexed with the C. Botulinum Neurotoxin Serotype A Catalytic Domain | | 分子名称: | Botulinum neurotoxin type A, ZINC ION, llama Aa1 VHH domain | | 著者 | Thompson, A.A, Dong, J, Marks, J.D, Stevens, R.C. | | 登録日 | 2009-10-04 | | 公開日 | 2010-02-23 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region.
J.Mol.Biol., 397, 2010
|
|
2NYY
 | |
5JMC
 | | Receptor binding domain of Botulinum neurotoxin A in complex with rat SV2C | | 分子名称: | Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C | | 著者 | Yao, G, Zhang, S, Mahrhold, S, Lam, K, Stern, D, Bagramyan, K, Perry, K, Kalkum, M, Rummel, A, Dong, M, Jin, R. | | 登録日 | 2016-04-28 | | 公開日 | 2016-06-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.
Nat.Struct.Mol.Biol., 23, 2016
|
|
6DKK
 | | Structure of BoNT | | 分子名称: | Botulinum neurotoxin type A, PHOSPHATE ION | | 著者 | Lam, K, Jin, R. | | 登録日 | 2018-05-29 | | 公開日 | 2018-12-26 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1.
Nat Commun, 9, 2018
|
|
8HKH
 | |
3V0A
 | | 2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BoNT/A, CALCIUM ION, ... | | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | | 登録日 | 2011-12-07 | | 公開日 | 2012-03-14 | | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
|
|
3ZUR
 | | Crystal structure of an engineered botulinum neurotoxin type A- SNARE23 derivative, LC0-A-SNAP25-Hn-A | | 分子名称: | BOTULINUM NEUROTOXIN TYPE A, SYNAPTOSOMAL-ASSOCIATED PROTEIN, SULFATE ION | | 著者 | Masuyer, G, Stancombe, P, Chaddock, J.A, Acharya, K.R. | | 登録日 | 2011-07-19 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives
Acta Crystallogr.,Sect.F, 67, 2011
|
|
7M1H
 | |
7KY2
 | |
7LZP
 | | LC/A-JPU-B9-JPU-A11-JPU-G11 | | 分子名称: | Botulinum neurotoxin A light chain, JPU-A11, JPU-B9, ... | | 著者 | Lam, K, Jin, R. | | 登録日 | 2021-03-10 | | 公開日 | 2021-12-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies.
Plos Pathog., 18, 2022
|
|
7KYH
 | | Botulism Neurooxin Light Chain A app form | | 分子名称: | Bont/A1, N-[(3,5-dichlorophenyl)sulfonyl]-L-phenylalanyl-N-hydroxy-L-valinamide, ZINC ION | | 著者 | Ortega, M.E, Salzameda, N.T. | | 登録日 | 2020-12-07 | | 公開日 | 2021-04-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors.
Acs Med.Chem.Lett., 12, 2021
|
|
3ZUS
 | | Crystal structure of an engineered botulinum neurotoxin type A- SNARE23 derivative, LC-A-SNAP23-Hn-A | | 分子名称: | BOTULINUM NEUROTOXIN TYPE A, SYNAPTOSOMAL-ASSOCIATED PROTEIN 23, ZINC ION | | 著者 | Masuyer, G, Stancombe, P, Chaddock, J.A, Acharya, K.R. | | 登録日 | 2011-07-19 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives
Acta Crystallogr.,Sect.F, 67, 2011
|
|
6MHJ
 | | Structure of BoNT mutant | | 分子名称: | Botulinum neurotoxin type A, PHOSPHATE ION | | 著者 | Lam, K, Jin, R. | | 登録日 | 2018-09-18 | | 公開日 | 2018-12-26 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.019 Å) | | 主引用文献 | A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1.
Nat Commun, 9, 2018
|
|
3BTA
 | |
2NZ9
 | |
3V0B
 | | 3.9 angstrom crystal structure of BoNT/Ai in complex with NTNHA | | 分子名称: | BoNT/A, CALCIUM ION, NTNH, ... | | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | | 登録日 | 2011-12-07 | | 公開日 | 2012-03-14 | | 最終更新日 | 2013-09-25 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
|
|
3V0C
 | | 4.3 angstrom crystal structure of an inactive BoNT/A (E224Q/R363A/Y366F) | | 分子名称: | BoNT/A, ZINC ION | | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | | 登録日 | 2011-12-07 | | 公開日 | 2012-03-14 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
|
|
