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PDB: 310 件
6UU3
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BU of 6uu3 by Molmil
E. coli sigma-S transcription initiation complex with a 4-nt RNA and a CTP ("Old" crystal soaked with GTP, ATP, CTP, and ddTTP for 30 minutes)
分子名称: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Zuo, Y, De, S, Steitz, T.A.
登録日2019-10-30
公開日2020-08-26
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (4.002 Å)
主引用文献Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation.
Iscience, 23, 2020
6VJS
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BU of 6vjs by Molmil
Escherichia coli RNA polymerase and ureidothiophene-2-carboxylic acid complex
分子名称: 3-{[benzyl(ethyl)carbamoyl]amino}-5-(4-phenoxyphenyl)thiophene-2-carboxylic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Murakami, K.S, Molodtsov, V.
登録日2020-01-17
公開日2020-10-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (4.02 Å)
主引用文献Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus -Based Wound Infection Model in SKH1 Mice.
Acs Infect Dis., 6, 2020
6JBQ
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BU of 6jbq by Molmil
CryoEM structure of Escherichia coli sigmaE transcription initiation complex containing 5nt of RNA
分子名称: DNA (48-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Fang, C.L, Zhang, Y.
登録日2019-01-26
公開日2019-05-29
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.02 Å)
主引用文献Structures and mechanism of transcription initiation by bacterial ECF factors.
Nucleic Acids Res., 47, 2019
6P1K
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BU of 6p1k by Molmil
Cryo-EM structure of Escherichia coli sigma70 bound RNAP polymerase holoenzyme
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A.
登録日2019-05-20
公開日2020-02-26
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.05 Å)
主引用文献E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation.
Elife, 8, 2019
6UTX
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BU of 6utx by Molmil
E. coli sigma-S transcription initiation complex with an empty bubble ("Old" crystal)
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Zuo, Y, De, S, Steitz, T.A.
登録日2019-10-30
公開日2020-08-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (4.05 Å)
主引用文献Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation.
Iscience, 23, 2020
8AC1
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BU of 8ac1 by Molmil
RNA polymerase at U-rich pause bound to non-regulatory RNA - inactive, open clamp state
分子名称: DNA Non-template strand, DNA Template strand, DNA-directed RNA polymerase subunit alpha, ...
著者Dey, S, Weixlbaumer, A.
登録日2022-07-05
公開日2022-10-26
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (4.06 Å)
主引用文献Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
6JNX
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BU of 6jnx by Molmil
Cryo-EM structure of a Q-engaged arrested complex
分子名称: Antiterminator Q protein, DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ...
著者Feng, Y, Shi, J.
登録日2019-03-18
公開日2019-06-12
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.08 Å)
主引用文献Structural basis of Q-dependent transcription antitermination.
Nat Commun, 10, 2019
4ZH3
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BU of 4zh3 by Molmil
Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Feng, Y, Ebright, R.H.
登録日2015-04-24
公開日2015-08-05
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (4.082 Å)
主引用文献Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.
Structure, 23, 2015
6UUC
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BU of 6uuc by Molmil
E. coli sigma-S transcription initiation complex with a 3-nt RNA and a mismatching ATP ("Fresh" crystal soaked with ATP for 2 hours)
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Zuo, Y, De, S, Steitz, T.A.
登録日2019-10-30
公開日2020-08-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (4.096 Å)
主引用文献Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation.
Iscience, 23, 2020
6UU1
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BU of 6uu1 by Molmil
E. coli sigma-S transcription initiation complex with a 4-nt RNA and a CTP ("Fresh" crystal soaked with CTP, GTP, and ddTTP for 30 minutes)
分子名称: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Zuo, Y, De, S, Steitz, T.A.
登録日2019-10-30
公開日2020-08-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (4.097 Å)
主引用文献Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation.
Iscience, 23, 2020
6X26
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BU of 6x26 by Molmil
Mfd-bound E.coli RNA polymerase elongation complex - L1 state
分子名称: DNA (64-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A.
登録日2020-05-20
公開日2021-02-03
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
6Z9R
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BU of 6z9r by Molmil
Transcription termination intermediate complex 3
分子名称: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ...
著者Said, N, Hilal, T, Loll, B, Wahl, M.C.
登録日2020-06-04
公開日2020-11-04
最終更新日2021-02-03
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho.
Science, 371, 2021
6ALF
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BU of 6alf by Molmil
CryoEM structure of crosslinked E.coli RNA polymerase elongation complex
分子名称: DNA (29-MER), DNA (5'-D(*GP*GP*GP*CP*TP*AP*AP*TP*GP*AP*CP*GP*GP*CP*GP*AP*AP*TP*AP*CP*CP*C)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Kang, J.Y, Darst, S.A.
登録日2017-08-07
公開日2017-08-16
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis of transcription arrest by coliphage HK022 Nun in anEscherichia coliRNA polymerase elongation complex.
Elife, 6, 2017
8AC0
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BU of 8ac0 by Molmil
RNA polymerase at U-rich pause bound to regulatory RNA putL - active, closed clamp state
分子名称: DNA Non-template strand, DNA Template strand, DNA-directed RNA polymerase subunit alpha, ...
著者Weixlbaumer, A, Dey, S.
登録日2022-07-05
公開日2022-10-19
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
8AD1
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BU of 8ad1 by Molmil
RNA polymerase at U-rich pause bound to RNA putL triple mutant - pause prone, closed clamp state
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Dey, S, Weixlbaumer, A.
登録日2022-07-07
公開日2022-10-19
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural insights into RNA-mediated transcription regulation in bacteria.
Mol.Cell, 82, 2022
6XH8
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BU of 6xh8 by Molmil
CueR-transcription activation complex with RNA transcript
分子名称: COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Liu, B, Shi, W, Yang, Y.
登録日2020-06-18
公開日2021-04-14
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis of copper-efflux-regulator-dependent transcription activation.
Iscience, 24, 2021
8E6Z
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BU of 8e6z by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, dC75 rut mimic RNA, Mg-ADP-BeF3, and NusG; TEC part
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Wang, C, Ebright, R.H.
登録日2022-08-23
公開日2022-09-07
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
7PYK
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BU of 7pyk by Molmil
CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA (NusA elongation complex in more-swiveled conformation)
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Zhu, C, Guo, X, Weixlbaumer, A.
登録日2021-10-10
公開日2022-03-23
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Transcription factors modulate RNA polymerase conformational equilibrium.
Nat Commun, 13, 2022
7PY7
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BU of 7py7 by Molmil
CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (NusA and NusG elongation complex in more-swiveled conformation)
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Zhu, C, Guo, X, Weixlbaumer, A.
登録日2021-10-09
公開日2022-03-23
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Transcription factors modulate RNA polymerase conformational equilibrium.
Nat Commun, 13, 2022
7PY6
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BU of 7py6 by Molmil
CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (NusA and NusG elongation complex in less-swiveled conformation)
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Zhu, C, Guo, X, Weixlbaumer, A.
登録日2021-10-09
公開日2022-03-23
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Transcription factors modulate RNA polymerase conformational equilibrium.
Nat Commun, 13, 2022
6FLP
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BU of 6flp by Molmil
CryoEM structure of E.coli RNA polymerase paused elongation complex without RNA hairpin bound to NusA
分子名称: DNA (30-MER), DNA (39-MER), DNA-directed RNA polymerase subunit alpha, ...
著者Guo, X, Weixlbaumer, A.
登録日2018-01-26
公開日2018-03-07
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural Basis for NusA Stabilized Transcriptional Pausing.
Mol. Cell, 69, 2018
6GH6
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BU of 6gh6 by Molmil
Cryo-EM structure of bacterial RNA polymerase-sigma54 holoenzyme intermediate partially loaded complex
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Glyde, R, Ye, F.Z, Zhang, X.D.
登録日2018-05-04
公開日2018-07-04
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structures of Bacterial RNA Polymerase Complexes Reveal the Mechanism of DNA Loading and Transcription Initiation.
Mol. Cell, 70, 2018
5UAH
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BU of 5uah by Molmil
Escherichia coli RNA polymerase and Rifampin complex, RpoB D516V mutant
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
6Z9T
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BU of 6z9t by Molmil
Transcription termination intermediate complex 5
分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ...
著者Said, N, Hilal, T, Loll, B, Wahl, M.C.
登録日2020-06-04
公開日2020-11-04
最終更新日2021-02-03
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho.
Science, 371, 2021
6VZJ
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BU of 6vzj by Molmil
Escherichia coli transcription-translation complex A1 (TTC-A1) containing mRNA with a 15 nt long spacer, fMet-tRNAs at E-site and P-site, and lacking transcription factor NusG
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
著者Molodtsov, V, Wang, C, Su, M, Ebright, R.H.
登録日2020-02-28
公開日2020-09-02
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis of transcription-translation coupling.
Science, 369, 2020

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