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PDB: 32 件

7X09
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Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with inhibitors L95 and Halofuginone
分子名称: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, BROMIDE ION, Bifunctional glutamate/proline--tRNA ligase, ...
著者Manickam, Y, Babbar, P, Pillai, P, Sharma, A.
登録日2022-02-21
公開日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of Homo sapiens Prolyl-tRNA synthetase (HsPRS) with double inhibitors (HF and L95)
To Be Published
7F99
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Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96
分子名称: 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.979 Å)
主引用文献Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7Y1H
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Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1
分子名称: 1-(5-chloranyl-4-methyl-benzimidazol-1-yl)-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one, ADENOSINE-5'-TRIPHOSPHATE, Bifunctional glutamate/proline--tRNA ligase, ...
著者Kim, S, Yoon, I, Son, J, Park, S, Hwang, K.Y.
登録日2022-06-08
公開日2023-07-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.
Embo Mol Med, 15, 2023
7F9B
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Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95
分子名称: Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, CHLORIDE ION, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.995 Å)
主引用文献Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F9A
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Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L97
分子名称: 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F98
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Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95
分子名称: Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, CHLORIDE ION, ...
著者Malhotra, N, Manickam, Y, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
4HVC
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Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue
分子名称: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Bifunctional glutamate/proline--tRNA ligase, MAGNESIUM ION, ...
著者Zhou, H, Sun, L, Yang, X.L, Schimmel, P.
登録日2012-11-06
公開日2013-01-02
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Nature, 494, 2012
7X1O
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Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with double inhibitors HF and L95
分子名称: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, BROMIDE ION, Bifunctional glutamate/proline--tRNA ligase, ...
著者Manickam, Y, Babbar, P, Sharma, A.
登録日2022-02-24
公開日2023-08-30
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Crystal structure of Homo sapiens Prolyl-tRNA synthetase (HsPRS) with double inhibitors (HF and L95)
To Be Published
5A1N
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The crystal structure of the GST-like domains complex of EPRS-AIMP2 mutant S156D
分子名称: AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 2, BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE, GLYCEROL
著者Cho, H.Y, Choi, Y.S, Kang, B.S.
登録日2015-05-03
公開日2016-06-01
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Symmetric Assembly of a Decameric Subcomplex in Human Multi-tRNA Synthetase Complex Via Interactions between Glutathione Transferase-Homology Domains and Aspartyl-tRNA Synthetase.
J.Mol.Biol., 2019
7BBU
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Crystal Structure of human Prolyl-tRNA synthetase in complex with NCP26 and L-Proline
分子名称: 1,2-ETHANEDIOL, Bifunctional glutamate/proline--tRNA ligase, CHLORIDE ION, ...
著者Johansson, C, Tye, M, Payne, N.C, Mazitschek, R, Krojer, T, Oppermann, U.C.T.
登録日2020-12-18
公開日2022-01-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Crystal Structure of human Prolyl-tRNA synthetase in complex with NCP26 and L-Proline
To Be Published
7F9C
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BU of 7f9c by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96
分子名称: 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
著者Malhotra, N, Manickam, Y, Sharma, A.
登録日2021-07-04
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.196 Å)
主引用文献Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7OSY
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BU of 7osy by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline
分子名称: Bifunctional glutamate/proline--tRNA ligase, PROLINE, STRONTIUM ION, ...
著者Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
登録日2021-06-09
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7Y28
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BU of 7y28 by Molmil
Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1
分子名称: 1-[6-(3-fluorophenyl)benzimidazol-1-yl]-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one, ADENOSINE-5'-TRIPHOSPHATE, Bifunctional glutamate/proline--tRNA ligase, ...
著者Kim, S, Yoon, I, Son, J, Park, S, Hwang, K.Y.
登録日2022-06-09
公開日2023-07-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.
Embo Mol Med, 15, 2023
4K87
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Crystal structure of human prolyl-tRNA synthetase (substrate bound form)
分子名称: ADENOSINE, PROLINE, Proline--tRNA ligase, ...
著者Hwang, K.Y, Son, J.H, Lee, E.H.
登録日2013-04-18
公開日2013-10-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.
Acta Crystallogr.,Sect.D, 69, 2013
5A5H
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The crystal structure of the GST-like domains complex of EPRS C92SC105SC123S mutant-AIMP2
分子名称: AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONA L PROTEIN 2, BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE
著者Cho, H.Y, Kang, B.S.
登録日2015-06-18
公開日2016-06-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.318 Å)
主引用文献The Crystal Structure of the Gst-Like Domains Complex of Eprs C92Sc105Sc123S Mutant-Aimp2
To be Published
7OT0
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Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4h
分子名称: 3-[(2-chlorophenyl)methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ...
著者Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
登録日2021-06-09
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
5VAD
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Crystal structure of human Prolyl-tRNA synthetase (PRS) in complex with inhibitor
分子名称: 3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ...
著者Okada, K, Skene, R.J.
登録日2017-03-24
公開日2017-05-31
最終更新日2017-06-07
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline.
Biochem. Biophys. Res. Commun., 488, 2017
4K86
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Crystal structure of human prolyl-tRNA synthetase (apo form)
分子名称: Proline--tRNA ligase, ZINC ION
著者Hwang, K.Y, Son, J.H, Lee, E.H.
登録日2013-04-18
公開日2013-10-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.
Acta Crystallogr.,Sect.D, 69, 2013
7OSZ
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Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4d
分子名称: 3-[(2-methylphenyl)methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ...
著者Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
登録日2021-06-09
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7OT2
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Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4j
分子名称: 3-[[2-(trifluoromethyl)phenyl]methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ...
著者Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
登録日2021-06-09
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7F9D
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BU of 7f9d by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96
分子名称: 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
著者Manickam, Y, Malhotra, N, Sharma, A.
登録日2021-07-04
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.497 Å)
主引用文献Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7Y1W
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Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1
分子名称: (2R,3S)-2-[3-[4,5-bis(chloranyl)benzimidazol-1-yl]propyl]piperidin-3-ol, ADENOSINE-5'-TRIPHOSPHATE, Bifunctional glutamate/proline--tRNA ligase, ...
著者Kim, S, Yoon, I, Son, J, Park, S, Hwang, K.Y.
登録日2022-06-09
公開日2023-07-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.
Embo Mol Med, 15, 2023
7OT3
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Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 3b
分子名称: Bifunctional glutamate/proline--tRNA ligase, PROLINE, STRONTIUM ION, ...
著者Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
登録日2021-06-09
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
5V58
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Crystal structure of human prolyl-tRNA synthetase in complex with Aze-SA
分子名称: 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine, Bifunctional glutamate/proline--tRNA ligase, ZINC ION
著者Zhou, H, Song, Y, Schimmel, P.
登録日2017-03-13
公開日2018-01-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
5BMU
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The crystal structure of the GST-like domains complex of AIMP3-EPRS mutant C92SC105SC123S
分子名称: Eukaryotic translation elongation factor 1 epsilon-1, Glutamate--tRNA ligase
著者Cho, H.J, Kang, B.S.
登録日2015-05-23
公開日2015-10-21
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains
J.Biol.Chem., 290, 2015

 

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