7F98

Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95

Summary for 7F98

• Entry DOI: 10.2210/pdb7f98/pdb
• Descriptor: Bifunctional glutamate/proline--tRNA ligase, ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide, ZINC ION, ... (7 entities in total)
• Functional Keywords: protein translation, malaria, inhibitor, prs, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 116567.78

Authors

Malhotra, N.,Manickam, Y.,Sharma, A. (deposition date: 2021-07-04, release date: 2022-10-05, Last modification date: 2023-11-29)

• Primary citation: Yogavel, M.,Bougdour, A.,Mishra, S.,Malhotra, N.,Chhibber-Goel, J.,Bellini, V.,Harlos, K.,Laleu, B.,Hakimi, M.A.,Sharma, A.; Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.; Plos Pathog., 19:e1011124-e1011124, 2023; PubMed: 36854028; DOI: 10.1371/journal.ppat.1011124

Experimental method

X-RAY DIFFRACTION (1.999 Å)