5ZK5
 
 | | Stapled-peptides tailored against initiation of translation | | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, LYS-ARG-TYR-SER-ARG-GLU-GLN-LEU-LEU-MK8-PHE-GLN-ARG-MK8 | | 著者 | Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M. | | 登録日 | 2018-03-23 | | 公開日 | 2019-02-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
|
|
2W97
 | | Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide | | 分子名称: | EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, GLYCEROL, ... | | 著者 | Brown, C.J, Verma, C.S, Walkinshaw, M.D, Lane, D.P. | | 登録日 | 2009-01-22 | | 公開日 | 2010-03-31 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site.
Cell Cycle, 8, 2009
|
|
2V8W
 | | Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | | 分子名称: | EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE | | 著者 | Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D. | | 登録日 | 2007-08-16 | | 公開日 | 2007-08-28 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives.
J.Mol.Biol., 372, 2007
|
|
2V8X
 | | Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | | 分子名称: | 7-BENZYL GUANINE MONOPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1 | | 著者 | Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D. | | 登録日 | 2007-08-16 | | 公開日 | 2007-08-28 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives.
J.Mol.Biol., 372, 2007
|
|
7EZW
 | |
5EHC
 | | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | | 分子名称: | 3-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-chlorophenyl)methyl]-6-oxidanylidene-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E | | 著者 | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | | 登録日 | 2015-10-28 | | 公開日 | 2016-09-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
Eur.J.Med.Chem., 124, 2016
|
|
7D8B
 | | Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways | | 分子名称: | Eukaryotic translation initiation factor 4E, VH-S4 | | 著者 | Frosi, Y, Lin, Y.C, Jiang, S, Brown, C.J. | | 登録日 | 2020-10-07 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
Nat Commun, 13, 2022
|
|
4BEA
 | | Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative | | 分子名称: | Eukaryotic translation initiation factor 4E, STAPLED EIF4E INTERACTING PEPTIDE | | 著者 | Quah, S.T, Lama, D, Verma, C.S, Lane, D.P, Brown, C.J. | | 登録日 | 2013-03-07 | | 公開日 | 2013-12-11 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Rational Optimization of Conformational Effects Induced by Hydrocarbon Staples in Peptides and Their Binding Interfaces.
Sci.Rep., 3, 2013
|
|
4DT6
 | | Co-crystal structure of eIF4E with inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 7-[2-(4-chlorophenoxy)ethyl]guanosine 5'-(dihydrogen phosphate), Eukaryotic translation initiation factor 4E, ... | | 著者 | Min, X, Johnstone, S, Walker, N, Wang, Z. | | 登録日 | 2012-02-20 | | 公開日 | 2012-04-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction.
J.Med.Chem., 55, 2012
|
|
5EIR
 | | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | | 分子名称: | Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E, SULFATE ION, ... | | 著者 | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | | 登録日 | 2015-10-30 | | 公開日 | 2016-09-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
Eur.J.Med.Chem., 124, 2016
|
|
4DUM
 | | Co-crystal structure of eIF4E with inhibitor | | 分子名称: | (4-{7-[2-(4-chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl}phenyl)phosphonic acid, 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 4E | | 著者 | Min, X, Johnstone, S, Walker, N, Wang, Z. | | 登録日 | 2012-02-22 | | 公開日 | 2012-04-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction.
J.Med.Chem., 55, 2012
|
|
5EKV
 | | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | | 分子名称: | 3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1 | | 著者 | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | | 登録日 | 2015-11-04 | | 公開日 | 2016-09-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.61 Å) | | 主引用文献 | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
Eur.J.Med.Chem., 124, 2016
|
|
2GPQ
 | |
