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PDB: 140 件
5KA5
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HIV-1 gp41 variant V549E resistance mutation
分子名称: Transmembrane glycoprotein gp41
著者Bhardwaj, A, Khasnis, M.D, Halkidis, K, Root, M.J.
登録日2016-06-01
公開日2016-12-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer.
PLoS Pathog., 12, 2016
3MNZ
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BU of 3mnz by Molmil
Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment with a gp41 MPER-derived peptide bearing Ala substitutions in a helical conformation
分子名称: ANTI-HIV-1 ANTIBODY 13H11 HEAVY CHAIN, ANTI-HIV-1 ANTIBODY 13H11 LIGHT CHAIN, SODIUM ION, ...
著者Nicely, N.I, Dennison, S.M, Kelsoe, G, Liao, H.-X, Alam, S.M, Haynes, B.F.
登録日2010-04-22
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of a Non-Neutralizing HIV-1 gp41 Envelope Antibody Demonstrates Neutralization Mechanism of gp41 Antibodies
To be Published
1GZL
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Crystal structure of C14linkmid/IQN17: a cross-linked inhibitor of HIV-1 entry bound to the gp41 hydrophobic pocket
分子名称: CHLORIDE ION, ENVELOPE GLYCOPROTEIN GP41, FUSION PROTEIN BETWEEN THE HYDROPHOBIC POCKET OF HIV GP41 AND GENERAL CONTROL PROTEIN GCN4-PIQI, ...
著者Sia, S.K, Carr, P.A, Cochran, A.G, Malashkevich, V.M, Kim, P.S.
登録日2002-05-23
公開日2002-10-10
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Short Constrained Peptides that Inhibit HIV-1 Entry
Proc.Natl.Acad.Sci.USA, 99, 2002
5CIL
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BU of 5cil by Molmil
Crystal Structure of non-neutralizing version of 4E10 (WDWD) with epitope bound
分子名称: ACETATE ION, CHLORIDE ION, FAB 4E10 HEAVY CHAIN, ...
著者Caaveiro, J.M.M, Rujas, E, Nieva, J.L, Tsumoto, K.
登録日2015-07-13
公開日2015-09-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10
J.Virol., 89, 2015
5KA6
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BU of 5ka6 by Molmil
HIV-1 gp41 variant Q552R and L555M resistance mutations
分子名称: Transmembrane protein gp41
著者Bhardwaj, A, Khasnis, M.D, Halkidis, K, Root, M.J.
登録日2016-06-01
公開日2016-12-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer.
PLoS Pathog., 12, 2016
1K34
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Crystal structure analysis of gp41 core mutant
分子名称: Transmembrane glycoprotein GP41
著者Shu, W, Lu, M.
登録日2001-10-01
公開日2001-10-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Interhelical interactions in the gp41 core: implications for activation of HIV-1 membrane fusion.
Biochemistry, 41, 2002
6PDS
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Vaccine-elicited NHP FP-targeting antibody 0PV-a.04 in complex with HIV fusion peptide (residue 512-519)
分子名称: HIV-1 fusion peptide residue 512-519, SULFATE ION, antibody 0PV-a.04 heavy chain, ...
著者Xu, K, Liu, K, Wang, Y, Kwong, P.D.
登録日2019-06-19
公開日2020-06-24
実験手法X-RAY DIFFRACTION (1.893 Å)
主引用文献Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
5Z0W
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BU of 5z0w by Molmil
Crystal structure of HIV-1 fusion inhibitor SC29EK complexed with gp41 NHR (N36)
分子名称: peptide-C, peptide-N
著者Liu, Z.X, Qin, B, Cui, S.
登録日2017-12-21
公開日2018-01-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.896 Å)
主引用文献Mechanism of HIV-1 Resistance to an Electronically Constrained alpha-Helical Peptide Membrane Fusion Inhibitor
J. Virol., 92, 2018
3VTP
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HIV fusion inhibitor MT-C34
分子名称: Transmembrane protein gp41
著者Yao, X, Waltersperger, S, Wang, M, Cui, S.
登録日2012-06-02
公開日2012-08-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The M-T hook structure is critical for design of HIV-1 fusion inhibitors.
J.Biol.Chem., 287, 2012
6R2G
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Crystal structure of a single-chain protein mimetic of the gp41 NHR trimer in complex with the synthetic CHR peptide C34
分子名称: Envelope glycoprotein gp160, PHOSPHATE ION, Single-chain protein mimetics of the N-terminal heptad-repeat region of gp41
著者Camara-Artigas, A, Conejero-Lara, F, Jurado, S, Cano-Munoz, M, Morel, B.
登録日2019-03-17
公開日2019-07-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Thermodynamic Analysis of HIV-1 Fusion Inhibition Using Small gp41 Mimetic Proteins.
J.Mol.Biol., 431, 2019
5CN0
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Artificial HIV fusion inhibitor AP2 fused to the C-terminus of gp41 NHR
分子名称: DI(HYDROXYETHYL)ETHER, Envelope glycoprotein,AP2, MAGNESIUM ION
著者Zhu, Y, Ye, S, Zhang, R.
登録日2015-07-17
公開日2015-09-16
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy.
Sci Rep, 5, 2015
6UBI
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N123-VRC34.05 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519
分子名称: HIV fusion peptide 512-519, VRC34.05 heavy chain, VRC34.05 light chain
著者Xu, K, Liu, K, Kwong, P.D.
登録日2019-09-11
公開日2020-03-18
最終更新日2020-04-22
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
Cell Host Microbe, 27, 2020
6PDU
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BU of 6pdu by Molmil
Vaccine-elicited NHP FP-targeting antibody 13N024-a.01 in complex with HIV fusion peptide (residue 512-519)
分子名称: HIV-1 fusion peptide residue 512-519, antibody 13N024-a.01, heavy chain, ...
著者Xu, K, Liu, K, Wang, Y, Kwong, P.D.
登録日2019-06-19
公開日2020-06-24
実験手法X-RAY DIFFRACTION (1.953 Å)
主引用文献Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6O3L
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BU of 6o3l by Molmil
Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41).
分子名称: GLYCEROL, MPER peptide, region 671-683 of HIV-1 gp41, ...
著者Irimia, A, Wilson, I.A.
登録日2019-02-26
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献An MPER antibody neutralizes HIV-1 using germline features shared among donors.
Nat Commun, 10, 2019
6MQC
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Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-c.01 in complex with FP (residue 512-519)
分子名称: 0PV-C.01 antibody Fab heavy chain, 0PV-C.01 antibody Fab light chain, HIV fusion peptide residue 512-519
著者Xu, K, Wang, Y, Kwong, P.D.
登録日2018-10-09
公開日2019-07-31
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
8F3B
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BU of 8f3b by Molmil
HIV-1 gp41 coiled-coil pocket IQN22
分子名称: IQN22
著者Bruun, T.U.J, Tang, S, Fernandez, D, Kim, P.S.
登録日2022-11-09
公開日2023-03-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies.
J.Biol.Chem., 299, 2023
7N08
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Crystal structure of the 3D6 antibody fragment bound to the HIV-1 gp41 immunodominant region
分子名称: Fab 3D6 heavy chain, Fab 3D6 light chain, HIV-1 gp41 immunodominant region
著者Cook, J.D, Lee, J.E.
登録日2021-05-25
公開日2022-03-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies.
Commun Biol, 5, 2022
5YC0
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BU of 5yc0 by Molmil
Crystal structure of LP-46/N44
分子名称: Envelope glycoprotein, LP-46
著者Zhang, X, Wang, X, He, Y.
登録日2017-09-05
公開日2018-02-14
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Exceptional potency and structural basis of a T1249-derived lipopeptide fusion inhibitor against HIV-1, HIV-2, and simian immunodeficiency virus
J. Biol. Chem., 293, 2018
2CMR
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BU of 2cmr by Molmil
Crystal structure of the HIV-1 neutralizing antibody D5 Fab bound to the gp41 inner-core mimetic 5-helix
分子名称: D5, GLYCEROL, TRANSMEMBRANE GLYCOPROTEIN
著者Luftig, M.A, Mattu, M, Di Giovine, P, Geleziunas, R, Hrin, R, Barbato, G, Bianchi, E, Miller, M.D, Pessi, A, Carfi, A.
登録日2006-05-11
公開日2006-10-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for HIV-1 Neutralization by a Gp41 Fusion Intermediate-Directed Antibody
Nat.Struct.Mol.Biol., 13, 2006
1DLB
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BU of 1dlb by Molmil
HELICAL INTERACTIONS IN THE HIV-1 GP41 CORE REVEALS STRUCTURAL BASIS FOR THE INHIBITORY ACTIVITY OF GP41 PEPTIDES
分子名称: HIV-1 ENVELOPE GLYCOPROTEIN GP41
著者Shu, W, Liu, J, Ji, H, Rading, L, Jiang, S, Lu, M.
登録日1999-12-09
公開日1999-12-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Helical interactions in the HIV-1 gp41 core reveal structural basis for the inhibitory activity of gp41 peptides.
Biochemistry, 39, 2000
1AIK
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BU of 1aik by Molmil
HIV GP41 CORE STRUCTURE
分子名称: HIV-1 GP41 GLYCOPROTEIN
著者Chan, D.C, Fass, D, Berger, J.M, Kim, P.S.
登録日1997-04-20
公開日1997-06-16
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Core structure of gp41 from the HIV envelope glycoprotein.
Cell(Cambridge,Mass.), 89, 1997
3G9R
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Structure of the HIV-1 gp41 Membrane-Proximal Ectodomain Region in a Putative Prefusion Conformation
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Fusion complex of HIV-1 Envelope glycoprotein and Saccharomyces cerevisiae General control protein GCN4, PHOSPHATE ION
著者Liu, J, Lu, M.
登録日2009-02-13
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the HIV-1 gp41 Membrane-Proximal Ectodomain Region in a Putative Prefusion Conformation.
Biochemistry, 48, 2009
2X7R
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Crystal structure of a late fusion intermediate of HIV-1 gp41
分子名称: CHLORIDE ION, SODIUM ION, TRANSMEMBRANE PROTEIN GP41
著者Natrajan, G, Buzon, V, Weissenhorn, W.
登録日2010-03-03
公開日2010-05-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of HIV-1 Gp41 Including Both Fusion Peptide and Membrane Proximal External Regions.
Plos Pathog., 6, 2010
6PEF
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Vaccine-elicited NHP FP-targeting antibody DF2F-a.01 in complex with HIV fusion peptide (residue 512-519)
分子名称: HIV fusion peptide residue 512-519, antibody DF2F-a.01 heavy chain, antibody DF2F-a.01 light chain
著者Xu, K, Liu, K, Wang, Y, Kwong, P.D.
登録日2019-06-20
公開日2020-06-24
実験手法X-RAY DIFFRACTION (2.004 Å)
主引用文献Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
5YB3
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Crystal structure of HP23L/N36
分子名称: Envelope glycoprotein, HP23L
著者Zhang, X, Wang, X, He, Y.
登録日2017-09-03
公開日2018-02-28
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.043 Å)
主引用文献Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket
Front Cell Infect Microbiol, 8, 2018

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件を2024-07-10に公開中

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