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6MQC

Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-c.01 in complex with FP (residue 512-519)

Summary for 6MQC
Entry DOI10.2210/pdb6mqc/pdb
Descriptor0PV-C.01 antibody Fab heavy chain, 0PV-C.01 antibody Fab light chain, HIV fusion peptide residue 512-519, ... (4 entities in total)
Functional Keywordshiv, neutralizing, nhp, fp, fusion peptide, vaccine, immune system
Biological sourceMacaca mulatta
More
Total number of polymer chains6
Total formula weight98029.67
Authors
Xu, K.,Wang, Y.,Kwong, P.D. (deposition date: 2018-10-09, release date: 2019-07-31, Last modification date: 2024-10-16)
Primary citationKong, R.,Duan, H.,Sheng, Z.,Xu, K.,Acharya, P.,Chen, X.,Cheng, C.,Dingens, A.S.,Gorman, J.,Sastry, M.,Shen, C.H.,Zhang, B.,Zhou, T.,Chuang, G.Y.,Chao, C.W.,Gu, Y.,Jafari, A.J.,Louder, M.K.,O'Dell, S.,Rowshan, A.P.,Viox, E.G.,Wang, Y.,Choi, C.W.,Corcoran, M.M.,Corrigan, A.R.,Dandey, V.P.,Eng, E.T.,Geng, H.,Foulds, K.E.,Guo, Y.,Kwon, Y.D.,Lin, B.,Liu, K.,Mason, R.D.,Nason, M.C.,Ohr, T.Y.,Ou, L.,Rawi, R.,Sarfo, E.K.,Schon, A.,Todd, J.P.,Wang, S.,Wei, H.,Wu, W.,Mullikin, J.C.,Bailer, R.T.,Doria-Rose, N.A.,Karlsson Hedestam, G.B.,Scorpio, D.G.,Overbaugh, J.,Bloom, J.D.,Carragher, B.,Potter, C.S.,Shapiro, L.,Kwong, P.D.,Mascola, J.R.
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178:567-584.e19, 2019
Cited by
PubMed Abstract: The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1 strains has been a long-standing goal. To understand how broadly neutralizing antibodies (bNAbs) can be elicited, we identified, characterized, and tracked five neutralizing Ab lineages targeting the HIV-1-fusion peptide (FP) in vaccinated macaques over time. Genetic and structural analyses revealed two of these lineages to belong to a reproducible class capable of neutralizing up to 59% of 208 diverse viral strains. B cell analysis indicated each of the five lineages to have been initiated and expanded by FP-carrier priming, with envelope (Env)-trimer boosts inducing cross-reactive neutralization. These Abs had binding-energy hotspots focused on FP, whereas several FP-directed Abs induced by immunization with Env trimer-only were less FP-focused and less broadly neutralizing. Priming with a conserved subregion, such as FP, can thus induce Abs with binding-energy hotspots coincident with the target subregion and capable of broad neutralization.
PubMed: 31348886
DOI: 10.1016/j.cell.2019.06.030
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.99 Å)
Structure validation

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