8GOH
 
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1JYE
 | | Structure of a Dimeric Lac Repressor with C-terminal Deletion and K84L Substitution | | 分子名称: | GLYCEROL, Lactose Operon Repressor | | 著者 | Bell, C.E, Barry, J, Matthews, K.S, Lewis, M. | | 登録日 | 2001-09-12 | | 公開日 | 2001-10-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator.
J.Mol.Biol., 313, 2001
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2P9H
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3EDC
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1TLF
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1EFA
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1LBI
 | | LAC REPRESSOR | | 分子名称: | LAC REPRESSOR | | 著者 | Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P. | | 登録日 | 1996-02-17 | | 公開日 | 1996-07-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
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4RZS
 | | Lac repressor engineered to bind sucralose, unliganded tetramer | | 分子名称: | GLYCEROL, Lac repressor | | 著者 | Arbing, M.A, Cascio, D, Kosuri, S, Church, G.M. | | 登録日 | 2014-12-24 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Engineering an allosteric transcription factor to respond to new ligands.
Nat.Methods, 13, 2016
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1JYF
 | | Structure of the Dimeric Lac Repressor with an 11-residue C-terminal Deletion. | | 分子名称: | GLYCEROL, Lactose Operon Repressor | | 著者 | Bell, C.E, Barry, J, Matthews, K.S, Lewis, M. | | 登録日 | 2001-09-12 | | 公開日 | 2001-10-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator.
J.Mol.Biol., 313, 2001
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4RZT
 | | Lac repressor engineered to bind sucralose, sucralose-bound tetramer | | 分子名称: | 4-chloro-4-deoxy-alpha-D-galactopyranose-(1-2)-1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose, Lac repressor | | 著者 | Arbing, M.A, Cascio, D, Sawaya, M.R, Kosuri, S, Church, G.M. | | 登録日 | 2014-12-24 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Engineering an allosteric transcription factor to respond to new ligands.
Nat.Methods, 13, 2016
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1LBH
 | | INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG | | 分子名称: | 1-methylethyl 1-thio-beta-D-galactopyranoside, INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG | | 著者 | Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P. | | 登録日 | 1996-02-17 | | 公開日 | 1996-07-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
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2PE5
 | | Crystal Structure of the Lac Repressor bound to ONPG in repressed state | | 分子名称: | 2-nitrophenyl beta-D-galactopyranoside, DNA (5'-D(*DAP*DAP*DTP*DTP*DGP*DTP*DGP*DAP*DGP*DCP*DGP*DCP*DTP*DCP*DAP*DCP*DAP*DAP*DTP*DT)-3'), Lactose operon repressor | | 著者 | Daber, R, Stayrook, S.E, Rosenberg, A, Lewis, M. | | 登録日 | 2007-04-02 | | 公開日 | 2008-03-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural analysis of lac repressor bound to allosteric effectors
J.Mol.Biol., 370, 2007
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2PAF
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1JWL
 | | Structure of the Dimeric lac Repressor/Operator O1/ONPF Complex | | 分子名称: | 2-nitrophenyl beta-D-fucopyranoside, 5'-D(*AP*GP*AP*AP*T*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*T)-3', 5'-D(*TP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', ... | | 著者 | Bell, C.E, Lewis, M. | | 登録日 | 2001-09-04 | | 公開日 | 2001-10-05 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Crystallographic analysis of Lac repressor bound to natural operator O1.
J.Mol.Biol., 312, 2001
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1LBG
 | | LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY | | 分子名称: | DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), PROTEIN (LACTOSE OPERON REPRESSOR) | | 著者 | Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P. | | 登録日 | 1996-01-03 | | 公開日 | 1996-02-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (4.8 Å) | | 主引用文献 | Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
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1OSL
 | | Solution structure of a dimeric lactose DNA-binding domain complexed to a nonspecific DNA sequence | | 分子名称: | 5'-D(*CP*GP*AP*TP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*AP*TP*CP*G)-3', Lactose operon repressor | | 著者 | Kalodimos, C.G, Bonvin, A.M.J.J, Boelens, R, Kaptein, R. | | 登録日 | 2003-03-20 | | 公開日 | 2004-05-04 | | 最終更新日 | 2021-10-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes.
Science, 305, 2004
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2BJC
 | | NMR structure of a protein-DNA complex of an altered specificity mutant of the lac repressor headpiece that mimics the gal repressor | | 分子名称: | 5'-D(*GP*AP*AP*TP*TP*GP*TP*AP*AP*GP *CP*GP*CP*TP*TP*AP*CP*AP*AP*TP*TP*C)-3', LACTOSE OPERON REPRESSOR | | 著者 | Salinas, R.K, Folkers, G.E, Bonvin, A.M.J.J, Das, D, Boelens, R, Kaptein, R. | | 登録日 | 2005-02-01 | | 公開日 | 2005-10-18 | | 最終更新日 | 2020-01-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Altered Specificity in DNA Binding by the Lac Repressor: A Mutant Lac Headpiece that Mimics the Gal Repressor
Chembiochem, 6, 2005
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2KEK
 | | Solution structure of a dimer of LAC repressor DNA-binding domain complexed to its natural operator O3 | | 分子名称: | DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*GP*AP*GP*CP*GP*CP*AP*AP*CP*GP*CP*AP*AP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*TP*TP*GP*CP*GP*TP*TP*GP*CP*GP*CP*TP*CP*AP*CP*TP*GP*CP*CP*G)-3'), Lactose operon repressor | | 著者 | Romanuka, J, Folkers, G, Biris, N, Tishchenko, E, Wienk, H, Kaptein, R, Boelens, R. | | 登録日 | 2009-01-30 | | 公開日 | 2009-05-19 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes.
J.Mol.Biol., 390, 2009
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2KEI
 | | Refined Solution Structure of a Dimer of LAC repressor DNA-Binding domain complexed to its natural operator O1 | | 分子名称: | DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*TP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3'), Lactose operon repressor | | 著者 | Romanuka, J, Folkers, G, Biris, N, Tishchenko, E, Wienk, H, Kaptein, R, Boelens, R. | | 登録日 | 2009-01-30 | | 公開日 | 2009-05-19 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes.
J.Mol.Biol., 390, 2009
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1L1M
 | | SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1 | | 分子名称: | 5'-D(*AP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', 5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*TP*T)-3', Lactose operon repressor | | 著者 | Kalodimos, C.G, Bonvin, A.M.J.J, Salinas, R.K, Wechselberger, R, Boelens, R, Kaptein, R. | | 登録日 | 2002-02-19 | | 公開日 | 2002-06-26 | | 最終更新日 | 2021-10-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator 01 through alternative conformations of its DNA-binding domain.
EMBO J., 21, 2002
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2KEJ
 | | Solution structure of a dimer of LAC repressor DNA-binding domain complexed to its natural operator O2 | | 分子名称: | DNA (5'-D(*GP*AP*AP*AP*TP*GP*TP*GP*AP*GP*CP*GP*AP*GP*TP*AP*AP*CP*AP*AP*CP*CP*G)-3'), DNA (5'-D(P*CP*GP*GP*TP*TP*GP*TP*TP*AP*CP*TP*CP*GP*CP*TP*CP*AP*CP*AP*TP*TP*TP*C)-3'), Lactose operon repressor | | 著者 | Romanuka, J, Folkers, G, Biris, N, Tishchenko, E, Wienk, H, Kaptein, R, Boelens, R. | | 登録日 | 2009-01-30 | | 公開日 | 2009-05-19 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes.
J.Mol.Biol., 390, 2009
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1CJG
 | | NMR STRUCTURE OF LAC REPRESSOR HP62-DNA COMPLEX | | 分子名称: | DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3'), PROTEIN (LAC REPRESSOR) | | 著者 | Spronk, C.A.E.M, Bonvin, A.M.J.J, Radha, P.K, Melacini, G, Boelens, R, Kaptein, R. | | 登録日 | 1999-04-14 | | 公開日 | 2000-01-01 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator.
Structure Fold.Des., 7, 1999
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1LQC
 | | LAC REPRESSOR HEADPIECE (RESIDUES 1-56), NMR, 32 STRUCTURES | | 分子名称: | LAC REPRESSOR | | 著者 | Slijper, M, Bonvin, A.M.J.J, Boelens, R, Kaptein, R. | | 登録日 | 1996-08-13 | | 公開日 | 1997-02-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Refined structure of lac repressor headpiece (1-56) determined by relaxation matrix calculations from 2D and 3D NOE data: change of tertiary structure upon binding to the lac operator.
J.Mol.Biol., 259, 1996
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1LCC
 | | STRUCTURE OF THE COMPLEX OF LAC REPRESSOR HEADPIECE AND AN 11 BASE-PAIR HALF-OPERATOR DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND RESTRAINED MOLECULAR DYNAMICS | | 分子名称: | DNA (5'-D(*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), Lac Repressor, ... | | 著者 | Chuprina, V.P, Rullmann, J.A.C, Lamerichs, R.M.J.N, Van Boom, J.H, Boelens, R, Kaptein, R. | | 登録日 | 1993-03-25 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics.
J.Mol.Biol., 234, 1993
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1LCD
 | | STRUCTURE OF THE COMPLEX OF LAC REPRESSOR HEADPIECE AND AN 11 BASE-PAIR HALF-OPERATOR DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND RESTRAINED MOLECULAR DYNAMICS | | 分子名称: | DNA (5'-D(*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), Lac Repressor, ... | | 著者 | Chuprina, V.P, Rullmann, J.A.C, Lamerichs, R.M.J.N, Van Boom, J.H, Boelens, R, Kaptein, R. | | 登録日 | 1993-03-25 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics.
J.Mol.Biol., 234, 1993
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