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PDB: 413 件
5K1J
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BU of 5k1j by Molmil
Human TTR altered by a rhenium tris-carbonyl Pyta-C8 derivative
分子名称: 1,2-ETHANEDIOL, ACETATE ION, DIMETHYL SULFOXIDE, ...
著者Stura, E.A, Ciccone, L, Shepard, W.
登録日2016-05-18
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Human TTR conformation altered by rhenium tris-carbonyl derivatives.
J.Struct.Biol., 195, 2016
4I87
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BU of 4i87 by Molmil
Crystal structure of TTR variant I84S in complex with CHF5074 at acidic pH
分子名称: 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid, Transthyretin
著者Zanotti, G, Cendron, L, Folli, C, Florio, P, Imbimbo, B.P, Berni, R.
登録日2012-12-03
公開日2013-06-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors.
Febs Lett., 587, 2013
8WGT
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BU of 8wgt by Molmil
Crystal structure of V30M-TTR in complex with compound 7
分子名称: Transthyretin, [4,7-bis(chloranyl)-2-ethyl-1-benzofuran-3-yl]-[3,5-bis(iodanyl)-4-oxidanyl-phenyl]methanone
著者Yokoyama, T.
登録日2023-09-22
公開日2024-05-15
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.696 Å)
主引用文献Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.
J.Med.Chem., 67, 2024
3IMR
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BU of 3imr by Molmil
Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dichlorostyryl)phenol
分子名称: 2,6-dibromo-4-[(E)-2-(2,6-dichlorophenyl)ethenyl]phenol, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2009-08-11
公開日2010-01-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
J.Am.Chem.Soc., 132, 2010
1ETA
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BU of 1eta by Molmil
THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION
分子名称: 3,5,3',5'-TETRAIODO-L-THYRONINE, TRANSTHYRETIN
著者Braden, B.C, Steinrauf, L.K, Hamilton, J.A.
登録日1993-05-12
公開日1995-01-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution.
J.Biol.Chem., 268, 1993
3NEX
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BU of 3nex by Molmil
V30M mutant human transthyretin (TTR) complexed with GC-24 (V30M:GC-24)
分子名称: GLYCEROL, Transthyretin, [4-(3-BENZYL-4-HYDROXYBENZYL)-3,5-DIMETHYLPHENOXY]ACETIC ACID
著者Trivella, D.B.B, Polikarpov, I.
登録日2010-06-09
公開日2010-11-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The binding of synthetic triiodo l-thyronine analogs to human transthyretin: molecular basis of cooperative and non-cooperative ligand recognition.
J.Struct.Biol., 173, 2011
1ETB
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BU of 1etb by Molmil
THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION
分子名称: 3,5,3',5'-TETRAIODO-L-THYRONINE, TRANSTHYRETIN
著者Braden, B.C, Steinrauf, L.K, Hamilton, J.A.
登録日1993-05-12
公開日1995-01-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution.
J.Biol.Chem., 268, 1993
1TTC
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BU of 1ttc by Molmil
THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION
分子名称: Transthyretin
著者Hamilton, J.A, Steinrauf, L.K, Braden, B.C.
登録日1992-11-02
公開日1993-10-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution.
J.Biol.Chem., 268, 1993
1TTB
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BU of 1ttb by Molmil
THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION
分子名称: TRANSTHYRETIN
著者Steinrauf, L.K, Hamilton, J.A, Braden, B.C.
登録日1992-11-02
公開日1993-10-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution.
J.Biol.Chem., 268, 1993
5LLV
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BU of 5llv by Molmil
Crystal structure of DACM F87M/L110M Transthyretin mutant
分子名称: ACETATE ION, CHLORIDE ION, Transthyretin
著者Sala, B.M, Ghadami, S.A, Bemporad, F, Chiti, F, Ricagno, S.
登録日2016-07-28
公開日2017-06-07
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献FRET studies of various conformational states adopted by transthyretin.
Cell. Mol. Life Sci., 74, 2017
3A4E
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BU of 3a4e by Molmil
Crystal structure of Human Transthyretin (E54G)
分子名称: GLYCEROL, SULFATE ION, Transthyretin
著者Miyata, M, Sato, T, Nakamura, T, Ikemizu, S, Yamagata, Y, Kai, H.
登録日2009-07-06
公開日2009-12-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Role of the glutamic acid 54 residue in transthyretin stability and thyroxine binding
Biochemistry, 49, 2010
4QYA
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BU of 4qya by Molmil
Crystal structure of human transthyretin variant V30M in complex with luteolin
分子名称: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, SODIUM ION, Transthyretin
著者Begum, A, Olofsson, A, Sauer-Eriksson, A.E.
登録日2014-07-24
公開日2015-06-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.
Plos One, 10, 2015
1TSH
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BU of 1tsh by Molmil
TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION
分子名称: TRANSTHYRETIN
著者Schormann, N, Murrell, J.R, Benson, M.D.
登録日1996-10-16
公開日1997-04-21
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Tertiary structures of amyloidogenic and non-amyloidogenic transthyretin variants: new model for amyloid fibril formation.
Amyloid, 5, 1998
6XTK
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BU of 6xtk by Molmil
Y114C Transthyretin structure in complex with Tolcalpone
分子名称: Tolcapone, Transthyretin
著者Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S.
登録日2020-01-16
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.
Febs J., 288, 2021
1Y1D
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BU of 1y1d by Molmil
Crystal structure of transthyretin in complex with iododiflunisal
分子名称: 2',4'-DIFLUORO-4-HYDROXY-5-IODO-1,1'-BIPHENYL-3-CARBOXYLIC ACID, Transthyretin
著者Gales, L, Macedo-Ribeiro, S, Arsequell, G, Valencia, G, Saraiva, M.J, Damas, A.M.
登録日2004-11-18
公開日2005-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor.
Biochem.J., 388, 2005
5U4C
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BU of 5u4c by Molmil
Wild-type Transthyretin in complex with 3-[(1E)-2-(4-Boronic acid)ethenyl]benzoic Acid
分子名称: 3-[(E)-2-(4-boronophenyl)ethenyl]benzoic acid, Transthyretin
著者Windsor, I.W, Smith, T.P, Raines, R.T, Forest, K.T.
登録日2016-12-03
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation.
J. Med. Chem., 60, 2017
3CBR
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BU of 3cbr by Molmil
Crystal structure of human Transthyretin (TTR) at pH3.5
分子名称: Transthyretin
著者Mohamedmohaideen, N.N, Palaninathan, S.K, Snee, W.C, Kelly, J.W, C Sacchettini, J.
登録日2008-02-22
公開日2008-08-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural insight into pH-induced conformational changes within the native human transthyretin tetramer.
J.Mol.Biol., 382, 2008
3U2I
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BU of 3u2i by Molmil
X-ray crystal structure of human Transthyretin at room temperature
分子名称: Transthyretin
著者Yokoyama, T, Mizuguchi, M, Nabeshima, Y, Kusaka, K, Yamada, T, Hosoya, T, Ohhara, T, Kurihara, K, Tomoyori, K, Tanaka, I, Niimura, N.
登録日2011-10-03
公開日2012-02-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin
J.Struct.Biol., 177, 2012
6D0W
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BU of 6d0w by Molmil
Structure of human transthyretin complex with analgesic inhibitor
分子名称: 2-[(3,5-dichlorophenyl)amino]benzoic acid, SODIUM ION, Transthyretin
著者Cody, V.
登録日2018-04-11
公開日2019-04-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Analysis of Human Transthyretin Analgesic Inhibitor Complex
To Be Published
1TTA
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BU of 1tta by Molmil
THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION
分子名称: TRANSTHYRETIN
著者Hamilton, J.A, Steinrauf, L.K, Braden, B.C.
登録日1992-11-02
公開日1993-10-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution.
J.Biol.Chem., 268, 1993
2B15
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BU of 2b15 by Molmil
The crystal structure of 2,4-dinitrophenol in complex with human transthyretin
分子名称: 2,4-DINITROPHENOL, SULFATE ION, Transthyretin
著者Morais-de-Sa, E, Neto-Silva, R.M, Pereira, P.J, Saraiva, M.J, Damas, A.M.
登録日2005-09-15
公開日2006-07-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
4ANK
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BU of 4ank by Molmil
Crystallographic study of novel transthyretin ligands exhibiting negative-cooperativity between two T4 binding sites.
分子名称: TRANSTHYRETIN
著者Tomar, D, Khan, T, Singh, R.R, Mishra, S, Gupta, S, Surolia, A, Salunke, D.M.
登録日2012-03-20
公開日2012-09-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystallographic Study of Novel Transthyretin Ligands Exhibiting Negative-Cooperativity between Two Thyroxine Binding Sites.
Plos One, 7, 2012
4TLT
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BU of 4tlt by Molmil
Crystal structure of human transthyretin
分子名称: MAGNESIUM ION, Transthyretin
著者Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S.
登録日2014-05-30
公開日2015-10-21
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Uncovering the Mechanism of Aggregation of Human Transthyretin.
J.Biol.Chem., 290, 2015
4ABQ
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BU of 4abq by Molmil
CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-1
分子名称: 3-(5-MERCAPTO-1,3,4-OXADIAZOL-2-YL)-PHENOL, TRANSTHYRETIN
著者Tomar, D, Khan, T, Singh, R.R, Mishra, S, Gupta, S, Surolia, A, Salunke, D.M.
登録日2011-12-10
公開日2012-09-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystallographic Study of Novel Transthyretin Ligands Exhibiting Negative-Cooperativity between Two Thyroxine Binding Sites.
Plos One, 7, 2012
3NG5
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Crystal Structure of V30M transthyretin complexed with (-)-epigallocatechin gallate (EGCG)
分子名称: (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, GLYCEROL, Transthyretin
著者Miyata, M, Nakamura, T, Ikemizu, S, Chirifu, M, Yamagata, Y, Kai, H.
登録日2010-06-11
公開日2010-07-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of green tea polyphenol(-)-epigallocatechin gallate (EGCG)-transthyretin complex reveals novel binding site distinct from thyroxine binding site
Biochemistry, 2010

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