3NEX

V30M mutant human transthyretin (TTR) complexed with GC-24 (V30M:GC-24)

Summary for 3NEX

Related3NEO 3NES 3NEE 3KGS 3KGU 3KGT
DescriptorTransthyretin, GLYCEROL, [4-(3-BENZYL-4-HYDROXYBENZYL)-3,5-DIMETHYLPHENOXY]ACETIC ACID, ... (4 entities in total)
Functional Keywordstransport protein, ttr, transthyretin, amyloid, gc-1, gc-24
Biological sourceHomo sapiens (human)
Cellular locationSecreted P02766
Total number of polymer chains2
Total molecular weight26407.64
Authors
Trivella, D.B.B.,Polikarpov, I. (deposition date: 2010-06-09, release date: 2010-11-24, Last modification date: 2011-07-13)
Primary citation
Trivella, D.B.,Sairre, M.I.,Foguel, D.,Lima, L.M.,Polikarpov, I.
The binding of synthetic triiodo l-thyronine analogs to human transthyretin: molecular basis of cooperative and non-cooperative ligand recognition.
J.Struct.Biol., 173:323-332, 2011
PubMed: 20937391 (PDB entries with the same primary citation)
DOI: 10.1016/j.jsb.2010.10.003
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2061101.5%7.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution