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PDB: 29 件
7FCR
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Crystal structure of the N-terminal domain of mutants of Human Apolipoprotein-E (ApoE)
分子名称: Apolipoprotein E, SODIUM ION
著者Cherakara, S, Kumar, A, Garai, K, Ghosh, B.
登録日2021-07-15
公開日2022-07-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structure of the N-terminal domain of mutants of Human Apolipoprotein-E (ApoE)
To be published
8AX9
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BU of 8ax9 by Molmil
Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P212121)
分子名称: Maltose/maltodextrin-binding periplasmic protein,Apolipoprotein E
著者Nemergut, M, Marek, M.
登録日2022-08-31
公開日2023-08-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.549 Å)
主引用文献Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.
Mol Neurodegener, 18, 2023
8AX8
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BU of 8ax8 by Molmil
Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P3121)
分子名称: Maltose/maltodextrin-binding periplasmic protein,Apolipoprotein E
著者Nemergut, M, Marek, M.
登録日2022-08-31
公開日2023-08-02
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.551 Å)
主引用文献Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.
Mol Neurodegener, 18, 2023
7FCS
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BU of 7fcs by Molmil
Crystal structure of the N-terminal domain of mutants of Human Apolipoprotein-E (ApoE)
分子名称: Apolipoprotein E, SODIUM ION
著者Cherakara, S, Kumar, A, Garai, K, Ghosh, B.
登録日2021-07-15
公開日2022-07-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of the N-terminal domain of mutants of Human Apolipoprotein-E (ApoE)
To be published
1GS9
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BU of 1gs9 by Molmil
Apolipoprotein E4, 22k domain
分子名称: APOLIPOPROTEIN E
著者Verderame, J.R, Kantardjieff, K, Segelke, B, Weisgraber, K, Rupp, B.
登録日2002-01-02
公開日2003-06-11
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of the 22K Domain of Human Apolipoprotein E4
To be Published
6NCO
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BU of 6nco by Molmil
Fragment-based Discovery of an apoE4 Stabilizer
分子名称: 1-[5-chloro-4'-(2-hydroxypropan-2-yl)[1,1'-biphenyl]-3-yl]cyclobutane-1-carboximidamide, Apolipoprotein E
著者Jakob, C.G, Qiu, W.
登録日2018-12-11
公開日2019-04-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.707 Å)
主引用文献Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer.
J.Med.Chem., 62, 2019
1OR3
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BU of 1or3 by Molmil
APOLIPOPROTEIN E3 (APOE3), TRIGONAL TRUNCATION MUTANT 165
分子名称: PROTEIN (APOLIPOPROTEIN E)
著者Rupp, B, Segelke, B.W.
登録日1998-12-01
公開日2000-05-24
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Conformational flexibility in the apolipoprotein E amino-terminal domain structure determined from three new crystal forms: implications for lipid binding.
Protein Sci., 9, 2000
8CE0
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BU of 8ce0 by Molmil
N-terminal domain of human apolipoprotein E
分子名称: GLYCEROL, Maltodextrin-binding protein,Apolipoprotein E
著者Marek, M, Nemergut, M.
登録日2023-02-01
公開日2023-07-19
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.
Mol Neurodegener, 18, 2023
1NFN
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APOLIPOPROTEIN E3 (APOE3)
分子名称: APOLIPOPROTEIN E3
著者Rupp, B, Parkin, S.
登録日1996-07-17
公開日1997-01-27
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia.
Nat.Struct.Biol., 3, 1996
6NCN
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Fragment-based Discovery of an apoE4 Stabilizer
分子名称: 1-(3-chlorophenyl)cyclobutane-1-carboximidamide, Apolipoprotein E
著者Jakob, C.G, Qiu, W.
登録日2018-12-11
公開日2019-04-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer.
J.Med.Chem., 62, 2019
1BZ4
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APOLIPOPROTEIN E3 (APO-E3), TRUNCATION MUTANT 165
分子名称: PROTEIN (APOLIPOPROTEIN E)
著者Rupp, B, Segelke, B.
登録日1998-11-05
公開日1998-11-11
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Conformational flexibility in the apolipoprotein E amino-terminal domain structure determined from three new crystal forms: implications for lipid binding.
Protein Sci., 9, 2000
8CDY
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BU of 8cdy by Molmil
N-terminal domain of human apolipoprotein E
分子名称: Maltodextrin-binding protein,Apolipoprotein E
著者Marek, M, Nemergut, M.
登録日2023-02-01
公開日2023-07-19
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.
Mol Neurodegener, 18, 2023
1H7I
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BU of 1h7i by Molmil
Apolipoprotein E3 22kD fragment LYS146GLN mutant
分子名称: APOLIPOPROTEIN E
著者Rupp, B, Peters-Libeu, C, Verderame, J.
登録日2001-07-08
公開日2001-07-31
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Apolipoprotein E3 22Kd Fragment Lys146Gln Mutant
To be Published
1EA8
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Apolipoprotein E3 22kD fragment LYS146GLU mutant
分子名称: APOLIPOPROTEIN E
著者Rupp, B, Peters-Libeu, C, Verderame, J.
登録日2001-07-11
公開日2001-07-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Apolipoprotein E3 22Kd Fragment Lys146Gln Mutant
To be Published
7UVJ
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BU of 7uvj by Molmil
Rationally Designed ED1 Epitope-Scaffold Immunogen for SARS-CoV-2
分子名称: ACETATE ION, Apolipoprotein E, DI(HYDROXYETHYL)ETHER, ...
著者Yennawar, N.H, Vishweshwaraiah, Y.L, Dokholyan, N.V.
登録日2022-05-02
公開日2022-10-12
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Adaptation-proof SARS-CoV-2 vaccine design.
Adv Funct Mater, 32, 2022
1NFO
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BU of 1nfo by Molmil
APOLIPOPROTEIN E2 (APOE2, D154A MUTATION)
分子名称: APOLIPOPROTEIN E2
著者Rupp, B, Parkin, S.
登録日1996-07-17
公開日1997-01-27
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia.
Nat.Struct.Biol., 3, 1996
6V7M
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BU of 6v7m by Molmil
Crystal structure of a proteolytically cleaved, amino terminal domain of apolipoprotein E3
分子名称: Apolipoprotein E, PHOSPHATE ION
著者McPherson, A.
登録日2019-12-08
公開日2020-03-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of a proteolytically cleaved, amino terminal domain of apolipoprotein E3.
Biochem.Biophys.Res.Commun., 2020
1B68
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BU of 1b68 by Molmil
APOLIPOPROTEIN E4 (APOE4), 22K FRAGMENT
分子名称: APOLIPOPROTEIN E
著者Rupp, B, Peters-Libeu, C.
登録日1999-01-21
公開日2001-07-11
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Interaction of the N-terminal domain of apolipoprotein E4 with heparin.
Biochemistry, 40, 2001
1LPE
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BU of 1lpe by Molmil
THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E
分子名称: APOLIPOPROTEIN E3
著者Wilson, C, Agard, D.A.
登録日1991-08-22
公開日1992-10-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.
Science, 252, 1991
1OR2
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BU of 1or2 by Molmil
APOLIPOPROTEIN E3 (APOE3) TRUNCATION MUTANT 165
分子名称: APOLIPOPROTEIN E
著者Rupp, B, Segelke, B.W, Forstner, M.
登録日1999-03-25
公開日2000-04-10
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Conformational flexibility in the apolipoprotein E amino-terminal domain structure determined from three new crystal forms: implications for lipid binding.
Protein Sci., 9, 2000
6IWB
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BU of 6iwb by Molmil
Crystal structure of a computationally designed protein (LD3) in complex with BCL-2
分子名称: Apolipoprotein E, Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2, SULFATE ION
著者Kim, S, Kwak, M.J, Oh, B.-H, Correia, B.E, Gainza, P.
登録日2018-12-05
公開日2019-12-11
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy.
Nat.Biotechnol., 38, 2020
1LE4
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BU of 1le4 by Molmil
STRUCTURAL BASIS FOR ALTERED FUNCTION IN THE COMMON MUTANTS OF HUMAN APOLIPOPROTEIN-E
分子名称: APOLIPOPROTEIN E4
著者Wilson, C, Agard, D.A.
登録日1991-08-22
公開日1992-10-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.
J.Biol.Chem., 269, 1994
8GRX
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APOE4 receptor in complex with APOE4 NTD
分子名称: Apolipoprotein E, Leukocyte immunoglobulin-like receptor subfamily A member 6
著者Zhou, J, Wang, Y, Huang, G, Shi, Y.
登録日2022-09-02
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献LilrB3 is a putative cell surface receptor of APOE4.
Cell Res., 33, 2023
1LE2
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STRUCTURAL BASIS FOR ALTERED FUNCTION IN THE COMMON MUTANTS OF HUMAN APOLIPOPROTEIN-E
分子名称: APOLIPOPROTEIN E2
著者Wilson, C, Agard, D.A.
登録日1991-08-22
公開日1992-10-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.
Structure, 2, 1994
1OEF
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PEPTIDE OF HUMAN APOE RESIDUES 263-286, NMR, 5 STRUCTURES AT PH 4.8, 37 DEGREES CELSIUS AND PEPTIDE:SDS MOLE RATIO OF 1:90
分子名称: APOLIPOPROTEIN E
著者Wang, G, Pierens, G.K, Treleaven, W.D, Sparrow, J.T, Cushley, R.J.
登録日1996-03-16
公開日1996-12-07
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Conformations of human apolipoprotein E(263-286) and E(267-289) in aqueous solutions of sodium dodecyl sulfate by CD and 1H NMR.
Biochemistry, 35, 1996

 

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