6IWB
Crystal structure of a computationally designed protein (LD3) in complex with BCL-2
Summary for 6IWB
| Entry DOI | 10.2210/pdb6iwb/pdb |
| Descriptor | Apolipoprotein E, Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | apoptosis |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 74595.62 |
| Authors | Kim, S.,Kwak, M.J.,Oh, B.-H.,Correia, B.E.,Gainza, P. (deposition date: 2018-12-05, release date: 2019-12-11, Last modification date: 2024-03-27) |
| Primary citation | Giordano-Attianese, G.,Gainza, P.,Gray-Gaillard, E.,Cribioli, E.,Shui, S.,Kim, S.,Kwak, M.J.,Vollers, S.,Corria Osorio, A.J.,Reichenbach, P.,Bonet, J.,Oh, B.H.,Irving, M.,Coukos, G.,Correia, B.E. A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy. Nat.Biotechnol., 38:426-432, 2020 Cited by PubMed: 32015549DOI: 10.1038/s41587-019-0403-9 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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