6IWB

Crystal structure of a computationally designed protein (LD3) in complex with BCL-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006869	biological_process	lipid transport
A	0008289	molecular_function	lipid binding
A	0042157	biological_process	lipoprotein metabolic process
B	0042981	biological_process	regulation of apoptotic process
B	0043066	biological_process	negative regulation of apoptotic process
C	0005576	cellular_component	extracellular region
C	0006869	biological_process	lipid transport
C	0008289	molecular_function	lipid binding
C	0042157	biological_process	lipoprotein metabolic process
D	0042981	biological_process	regulation of apoptotic process
D	0043066	biological_process	negative regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 A 201

Chain	Residue
A	ARG101
A	ARG123
A	HIS127
A	HOH301
A	HOH303
C	ARG101
C	ARG123
C	HIS127

---

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 202

Chain	Residue
A	ARG99
C	ARG12
A	ARG48

---

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	19
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG

Chain	Residue	Details
B	LEU96-GLY114

---

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV

Chain	Residue	Details
B	TRP147-VAL158

---

site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhltLRqAGDDFSRR

Chain	Residue	Details
B	VAL52-ARG66

---

site_id	PS01260
Number of Residues	21
Details	BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW

Chain	Residue	Details
B	ASP10-TRP30

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Repeat: {"description":"1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	Repeat: {"description":"2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Repeat: {"description":"3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	Repeat: {"description":"4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Region: {"description":"LDL and other lipoprotein receptors binding","evidences":[{"source":"PubMed","id":"20030366","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2063194","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"3947350","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Methionine sulfoxide","evidences":[{"source":"UniProtKB","id":"P08226","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"10452964","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	40
Details	Motif: {"description":"BH4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00025","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	28
Details	Motif: {"description":"BH3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	38
Details	Motif: {"description":"BH1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	30
Details	Motif: {"description":"BH2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---