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PDB: 32 件
2FCW
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Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP).
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-2-macroglobulin receptor-associated protein, CALCIUM ION, ...
著者Beglova, N, Fisher, C, Blacklow, S.C.
登録日2005-12-12
公開日2006-05-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein Receptors
Mol.Cell, 22, 2006
3SO6
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Crystal structure of the LDL receptor tail in complex with autosomal recessive hypercholesterolemia PTB domain
分子名称: LDL receptor adaptor protein, Low-density lipoprotein receptor
著者Dvir, H, Zajonc, D.M.
登録日2011-06-29
公開日2012-04-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.
Proc.Natl.Acad.Sci.USA, 109, 2012
1IJQ
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Crystal Structure of the LDL Receptor YWTD-EGF Domain Pair
分子名称: LOW-DENSITY LIPOPROTEIN RECEPTOR
著者Jeon, H, Meng, W, Takagi, J, Eck, M.J, Springer, T.A, Blacklow, S.C.
登録日2001-04-27
公開日2001-05-23
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
Nat.Struct.Biol., 8, 2001
1AJJ
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BU of 1ajj by Molmil
LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING
分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, SULFATE ION
著者Fass, D, Blacklow, S.C, Kim, P.S, Berger, J.M.
登録日1997-05-04
公開日1997-07-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module.
Nature, 388, 1997
5OYL
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BU of 5oyl by Molmil
VSV G CR2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ...
著者Albertini, A.A, Belot, L, Legrand, P, Gaudin, Y.
登録日2017-09-11
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein.
Nat Commun, 9, 2018
2W2N
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BU of 2w2n by Molmil
WT PCSK9-deltaC bound to EGF-A H306Y mutant of LDLR
分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
著者Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A.
登録日2008-11-03
公開日2008-11-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2Q
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PCSK9-deltaC D374H mutant bound to WT EGF-A of LDLR
分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
著者Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A.
登録日2008-11-03
公開日2008-11-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2M
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WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR
分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
著者Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A.
登録日2008-11-03
公開日2008-11-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
3BPS
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BU of 3bps by Molmil
PCSK9:EGF-A complex
分子名称: CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9
著者Kwon, H.J.
登録日2007-12-19
公開日2008-02-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Molecular basis for LDL receptor recognition by PCSK9.
Proc.Natl.Acad.Sci.Usa, 105, 2008
4NE9
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PCSK9 in complex with LDLR peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor, ...
著者Liu, S.
登録日2013-10-28
公開日2014-09-10
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.
Chem.Biol., 21, 2014
2W2O
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BU of 2w2o by Molmil
PCSK9-deltaC D374Y mutant bound to WT EGF-A of LDLR
分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
著者Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A.
登録日2008-11-03
公開日2008-11-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
2W2P
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PCSK9-deltaC D374A mutant bound to WT EGF-A of LDLR
分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
著者Bottomley, M.J, Cirillo, A, Orsatti, L, Ruggeri, L, Fisher, T.S, Santoro, J.C, Cummings, R.T, Cubbon, R.M, Lo Surdo, P, Calzetta, A, Noto, A, Baysarowich, J, Mattu, M, Talamo, F, De Francesco, R, Sparrow, C.P, Sitlani, A, Carfi, A.
登録日2008-11-03
公開日2008-11-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants.
J.Biol.Chem., 284, 2009
3GCX
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BU of 3gcx by Molmil
PCSK9:EGFA (pH 7.4)
分子名称: CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9
著者McNutt, M.C, Kwon, H.J, Chen, C, Chen, J.R, Horton, J.D, Lagace, T.A.
登録日2009-02-22
公開日2009-03-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells.
J.Biol.Chem., 284, 2009
3GCW
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BU of 3gcw by Molmil
PCSK9:EGFA(H306Y)
分子名称: CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9
著者Kwon, H.J.
登録日2009-02-22
公開日2009-03-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells.
J.Biol.Chem., 284, 2009
3P5B
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BU of 3p5b by Molmil
The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
分子名称: CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9
著者Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A.
登録日2010-10-08
公開日2011-10-26
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
5OY9
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BU of 5oy9 by Molmil
VSV G CR3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Albertini, A.A, Belot, L, Legrand, P, Gaudin, Y.
登録日2017-09-08
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein.
Nat Commun, 9, 2018
1N7D
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BU of 1n7d by Molmil
Extracellular domain of the LDL receptor
分子名称: 12-TUNGSTOPHOSPHATE, CALCIUM ION, Low-density lipoprotein receptor, ...
著者Rudenko, G, Henry, L, Henderson, K, Ichtchenko, K, Brown, M.S, Goldstein, J.L, Deisenhofer, J.
登録日2002-11-13
公開日2003-01-21
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Structure of the LDL receptor extracellular domain at endosomal pH
Science, 298, 2002
3P5C
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BU of 3p5c by Molmil
The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
分子名称: CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9
著者Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A.
登録日2010-10-08
公開日2011-10-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
3M0C
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BU of 3m0c by Molmil
The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor
分子名称: CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9
著者Spraggon, G, Hampton, E.N.
登録日2010-03-02
公開日2011-03-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (7.01 Å)
主引用文献The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor
To be Published
1HZ8
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BU of 1hz8 by Molmil
SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A CONCATEMER OF EGF-HOMOLOGY MODULES OF THE HUMAN LOW DENSITY LIPOPROTEIN RECEPTOR
分子名称: CALCIUM ION, LOW DENSITY LIPOPROTEIN RECEPTOR
著者Kurniawan, N.D, Aliabadizadeh, K, Brereton, I.M, Kroon, P.A, Smith, R.
登録日2001-01-23
公開日2001-08-15
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献NMR structure and backbone dynamics of a concatemer of epidermal growth factor homology modules of the human low-density lipoprotein receptor.
J.Mol.Biol., 311, 2001
1I0U
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BU of 1i0u by Molmil
SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A CONCATEMER OF EGF-HOMOLOGY MODULES OF THE HUMAN LOW DENSITY LIPOPROTEIN RECEPTOR
分子名称: CALCIUM ION, LOW DENSITY LIPOPROTEIN RECEPTOR
著者Kurniawan, N.D, Aliabadizadeh, K, Brereton, I.M, Kroon, P.A, Smith, R.
登録日2001-01-29
公開日2001-08-15
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献NMR structure and backbone dynamics of a concatemer of epidermal growth factor homology modules of the human low-density lipoprotein receptor.
J.Mol.Biol., 311, 2001
2MG9
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BU of 2mg9 by Molmil
Truncated EGF-A
分子名称: CALCIUM ION, Low-density lipoprotein receptor
著者Schroeder, C.I, Rosengren, K.
登録日2013-10-30
公開日2014-04-02
実験手法SOLUTION NMR
主引用文献Design and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro.
Chem.Biol., 21, 2014
2M7P
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RXFP1 utilises hydrophobic moieties on a signalling surface of the LDLa module to mediate receptor activation
分子名称: CALCIUM ION, Low-density lipoprotein receptor, Relaxin receptor 1
著者Kong, R.CK, Petrie, E.J, Mohanty, B, Ling, J, Lee, J.C.Y, Gooley, P.R, Bathgate, R.A.D.
登録日2013-04-29
公開日2013-08-14
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation.
J.Biol.Chem., 288, 2013
1XFE
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BU of 1xfe by Molmil
Solution structure of the LA7-EGFA pair from the LDL receptor
分子名称: CALCIUM ION, Low-density lipoprotein receptor
著者Beglova, N, Jeon, H, Fisher, C, Blacklow, S.C.
登録日2004-09-14
公開日2004-11-02
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Cooperation between Fixed and Low pH-Inducible Interfaces Controls Lipoprotein Release by the LDL Receptor
Mol.Cell, 16, 2004
1D2J
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LDL RECEPTOR LIGAND-BINDING MODULE 6
分子名称: CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR
著者North, C.L, Blacklow, S.C.
登録日1999-09-23
公開日2000-03-22
最終更新日2021-11-03
実験手法SOLUTION NMR
主引用文献Solution structure of the sixth LDL-A module of the LDL receptor.
Biochemistry, 39, 2000

 

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