1NRL
| Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813 | 分子名称: | Nuclear Receptor Coactivator 1 isoform 3, Orphan nuclear receptor PXR, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER | 著者 | Watkins, R.E, Davis-Searles, P.R, Lambert, M.H, Redinbo, M.R. | 登録日 | 2003-01-25 | 公開日 | 2003-08-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor J.Mol.Biol., 331, 2003
|
|
1SKX
| Structural Disorder in the Complex of Human PXR and the Macrolide Antibiotic Rifampicin | 分子名称: | Orphan nuclear receptor PXR, RIFAMPICIN | 著者 | Chrencik, J.E, Xue, Y, Orans, J.O, Redinbo, M.R. | 登録日 | 2004-03-05 | 公開日 | 2005-03-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural disorder in the complex of human pregnane x receptor and the macrolide antibiotic rifampicin Mol.Endocrinol., 19, 2005
|
|
2O9I
| Crystal Structure of the Human Pregnane X Receptor LBD in complex with an SRC-1 coactivator peptide and T0901317 | 分子名称: | N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, Nuclear Receptor Coactivator 1 isoform 3, Orphan nuclear receptor PXR | 著者 | Xue, Y, Redinbo, M.R. | 登録日 | 2006-12-13 | 公開日 | 2007-01-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Bioorg.Med.Chem., 15, 2007
|
|
2QNV
| Crystal Structure of the Pregnane X Receptor bound to Colupulone | 分子名称: | 3,5-dihydroxy-4,6,6-tris(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)cyclohexa-2,4-dien-1-one, Orphan nuclear receptor PXR | 著者 | Teotico, D.G, Bischof, J, Redinbo, M.R. | 登録日 | 2007-07-19 | 公開日 | 2008-07-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of the Pregnane X Receptor bound to Colupulone TO BE PUBLISHED
|
|
1ILH
| |
1ILG
| |
1M13
| Crystal Structure of the Human Pregane X Receptor Ligand Binding Domain in Complex with Hyperforin, a Constituent of St. John's Wort | 分子名称: | 4-HYDROXY-5-ISOBUTYRYL-6-METHYL-1,3,7-TRIS-(3-METHYL-BUT-2-ENYL)-6-(4-METHYL-PENT-3-ENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE, Orphan Nuclear Receptor PXR | 著者 | Watkins, R.E, Maglich, J.M, Moore, L.B, Wisely, G.B, Noble, S.M, Davis-Searles, P.R, Lambert, M.H, Kliewer, S.A, Redinbo, M.R. | 登録日 | 2002-06-17 | 公開日 | 2003-03-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | 2.1 A Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin Biochemistry, 42, 2003
|
|
6P2B
| Tethered PXR-LBD/SRC-1p bound to Garcinoic Acid | 分子名称: | (2Z,6E,10E)-13-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-1-benzopyran-2-yl]-2,6,10-trimethyltrideca-2,6,10-trienoic acid, DIMETHYL SULFOXIDE, Nuclear receptor subfamily 1 group I member 2 | 著者 | Walton, W.G, Pellock, S.J, Redinbo, M.R. | 登録日 | 2019-05-21 | 公開日 | 2020-04-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. J.Med.Chem., 63, 2020
|
|
4NY9
| Crystal Structure Of the Human PXR-LBD In Complex With N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-3-hydroxy-3-methylbutanamide | 分子名称: | GLYCEROL, N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-3-hydroxy-3-methylbutanamide, Nuclear receptor subfamily 1 group I member 2 | 著者 | Khan, J.A, Camac, D.M. | 登録日 | 2013-12-10 | 公開日 | 2014-08-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J.Med.Chem., 57, 2014
|
|
6XP9
| |
3HVL
| Tethered PXR-LBD/SRC-1p complexed with SR-12813 | 分子名称: | Pregnane X receptor, Linker, Steroid receptor coactivator 1, ... | 著者 | Lesburg, C.A, Wang, W, Prosise, W.W, Chen, J, Taremi, S.S, Le, H.V, Madison, V, Cui, X, Thomas, A, Cheng, K.C. | 登録日 | 2009-06-16 | 公開日 | 2009-08-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability Protein Eng.Des.Sel., 21, 2008
|
|
7N2A
| human PXR LBD bound to compound 2 | 分子名称: | 5-benzyl-2-(3-fluoro-2-hydroxyphenyl)-6-methyl-3-(2-phenylethyl)pyrimidin-4(3H)-one, Isoform 1C of Nuclear receptor subfamily 1 group I member 2 | 著者 | Williams, S.P, Wisely, G.B, Ramanjulu, J.M. | 登録日 | 2021-05-28 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction. Acs Med.Chem.Lett., 12, 2021
|
|
6NX1
| STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TETHERED WITH SRC CO-ACTIVATOR PEPTIDE AND COMPOUND-3 AKA 1,1,1,3,3,3-HEXAFLUORO-2-{4-[1-(4- LUOROBENZENESULFONYL)CYCLOPENTYL]PHENYL}PROPAN-2-OL | 分子名称: | 1,1,1,3,3,3-hexafluoro-2-(4-{1-[(4-fluorophenyl)sulfonyl]cyclopentyl}phenyl)propan-2-ol, Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 fusion | 著者 | Khan, J.A. | 登録日 | 2019-02-07 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active ROR gamma t Inverse Agonists. Acs Med.Chem.Lett., 10, 2019
|
|
3CTB
| Tethered PXR-LBD/SRC-1p apoprotein | 分子名称: | Pregnane X receptor, Linker, Steroid receptor coactivator 1 | 著者 | Lesburg, C.A. | 登録日 | 2008-04-11 | 公開日 | 2008-12-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability Protein Eng.Des.Sel., 21, 2008
|
|
5A86
| |
3R8D
| |
7YFK
| The structure of human pregnane X receptor in complex with an SRC-1 coactivator peptide and a limonoid compound, nomilin | 分子名称: | Nomilin, Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 | 著者 | Xia, Y, Yao, D, Huang, C, Cao, Y. | 登録日 | 2022-07-08 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions. Nat Commun, 14, 2023
|
|
5X0R
| Crystal Structure of PXR LBD Complexed with SJB7 | 分子名称: | 4-[(4-tert-butylphenyl)sulfonyl]-1-(2,4-dimethoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole, Nuclear receptor coactivator 1, Nuclear receptor subfamily 1 group I member 2 | 著者 | Lv, L, Lin, W, Chai, S.C, Zhang, Q, Chen, T. | 登録日 | 2017-01-23 | 公開日 | 2017-10-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.665 Å) | 主引用文献 | SPA70 is a potent antagonist of human pregnane X receptor. Nat Commun, 8, 2017
|
|
4S0T
| |
6S41
| CRYSTAL STRUCTURE OF PXR IN COMPLEX WITH XPC-7455 | 分子名称: | 4-[[(1~{S})-1-[2,5-bis(fluoranyl)phenyl]ethyl]amino]-5-chloranyl-2-fluoranyl-~{N}-(1,3-thiazol-4-yl)benzenesulfonamide, Nuclear receptor subfamily 1 group I member 2 | 著者 | Focken, T, Maskos, K, Griessner, A, Krapp, S. | 登録日 | 2019-06-26 | 公開日 | 2019-10-02 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J.Med.Chem., 62, 2019
|
|
4XHD
| STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN WITH COMPOUND-1 | 分子名称: | GLYCEROL, N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-cyclopropylacetamide, Nuclear receptor subfamily 1 group I member 2 | 著者 | Khan, J.A, Camac, D.M. | 登録日 | 2015-01-05 | 公開日 | 2015-01-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR. J.Mol.Biol., 427, 2015
|
|
8F5Y
| Crystal structure of pregnane X receptor ligand binding domain complexed with JQ1 | 分子名称: | (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, Nuclear receptor coactivator 1, Nuclear receptor subfamily 1 group I member 2 | 著者 | Huber, A.D, Poudel, S, Seetharaman, J, Miller, D.J, Chen, T. | 登録日 | 2022-11-15 | 公開日 | 2024-02-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR. Nucleic Acids Res., 52, 2024
|
|
4S0S
| |
4J5X
| Crystal Structure of the SR12813-bound PXR/RXRalpha LBD Heterotetramer Complex | 分子名称: | Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, ... | 著者 | Wallace, B.D, Betts, L, Redinbo, M.R. | 登録日 | 2013-02-10 | 公開日 | 2013-08-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRalpha. J.Mol.Biol., 425, 2013
|
|
8FPE
| Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog T0-BP | 分子名称: | N-[([1,1'-biphenyl]-4-yl)methyl]-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzenesulfonamide, Nuclear receptor subfamily 1 group I member 2 | 著者 | Huber, A.D, Poudel, S, Seetharaman, J, Miller, D.J, Lin, W, Li, Y, Chen, T. | 登録日 | 2023-01-04 | 公開日 | 2023-03-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|