8FPE

Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog T0-BP

Summary for 8FPE

Entry DOI	10.2210/pdb8fpe/pdb
Descriptor	Nuclear receptor subfamily 1 group I member 2, N-[([1,1'-biphenyl]-4-yl)methyl]-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzenesulfonamide (3 entities in total)
Functional Keywords	nuclear receptor, transcription factor, metabolism, antibiotic, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	36774.27
Authors	Huber, A.D.,Poudel, S.,Seetharaman, J.,Miller, D.J.,Lin, W.,Li, Y.,Chen, T. (deposition date: 2023-01-04, release date: 2023-03-15)
Primary citation	Lin, W.,Huber, A.D.,Poudel, S.,Li, Y.,Seetharaman, J.,Miller, D.J.,Chen, T. Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein. Proc.Natl.Acad.Sci.USA, 120:e2217804120-e2217804120, 2023 Cited by PubMed: 36848571 DOI: 10.1073/pnas.2217804120 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation