8C78
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![BU of 8c78 by Molmil](/molmil-images/mine/8c78) | Crystal structure of human BCL6 BTB domain in complex with compound CCT374705 | Descriptor: | (2~{S})-10-[(3-chloranyl-2-fluoranyl-pyridin-4-yl)amino]-2-cyclopropyl-3,3-bis(fluoranyl)-7-methyl-2,4-dihydro-1~{H}-[1,4]oxazepino[2,3-c]quinolin-6-one, 1,2-ETHANEDIOL, B-cell lymphoma 6 protein, ... | Authors: | Le Bihan, Y.-V, van Montfort, R.L.M. | Deposit date: | 2023-01-13 | Release date: | 2023-04-26 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones. J.Med.Chem., 66, 2023
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6N34
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![BU of 6n34 by Molmil](/molmil-images/mine/6n34) | Crystal structure of the BTB domain of Human NS1-BP | Descriptor: | Influenza virus NS1A-binding protein | Authors: | Zhang, K, Shang, G, Padavannil, A, Fontoura, B, Chook, Y.M. | Deposit date: | 2018-11-14 | Release date: | 2018-12-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7EXI
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![BU of 7exi by Molmil](/molmil-images/mine/7exi) | |
4UYI
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![BU of 4uyi by Molmil](/molmil-images/mine/4uyi) | Crystal structure of the BTB domain of human SLX4 (BTBD12) | Descriptor: | STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4 | Authors: | Pinkas, D.M, Sanvitale, C.E, Strain-Damerell, C, Fairhead, M, Wang, D, Tallant, C, Cooper, C.D.O, Sorrell, F.J, Kopec, J, Chaikuad, A, Fitzpatrick, F, Pike, A.C.W, Hozjan, V, Ying, Z, Roos, A.K, Savitsky, P, Bradley, A, Nowak, R, Filippakopoulos, P, Krojer, T, Burgess-Brown, N.A, Marsden, B.D, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. | Deposit date: | 2014-09-01 | Release date: | 2014-10-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal Structure of the Btb Domain of Human Slx4 (Btbd12) To be Published
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4ZOU
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![BU of 4zou by Molmil](/molmil-images/mine/4zou) | |
1BUO
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![BU of 1buo by Molmil](/molmil-images/mine/1buo) | BTB DOMAIN FROM PLZF | Descriptor: | PROTEIN (PROMYELOCYTIC LEUKEMIA ZINC FINGER PROTEIN PLZF) | Authors: | Ahmad, K.F, Engel, C.K, Prive, G.G. | Deposit date: | 1998-09-04 | Release date: | 1998-10-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the BTB domain from PLZF. Proc.Natl.Acad.Sci.USA, 95, 1998
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7BDE
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![BU of 7bde by Molmil](/molmil-images/mine/7bde) | HUMAN BCL6 BTB-DOMAIN IN COMPLEX WITH GSK137 | Descriptor: | 5-[(5S,7R)-3-fluoranyl-7-(2-methylpyridin-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-5-yl]quinolin-2-amine, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Somers, D.O. | Deposit date: | 2020-12-21 | Release date: | 2021-07-28 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.044 Å) | Cite: | GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice. J.Biol.Chem., 297, 2021
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1CS3
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![BU of 1cs3 by Molmil](/molmil-images/mine/1cs3) | |
3E4U
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![BU of 3e4u by Molmil](/molmil-images/mine/3e4u) | Crystal Structure of the Wild-Type Human BCL6 BTB/POZ Domain | Descriptor: | B-cell lymphoma 6 protein | Authors: | Stead, M.A, Rosbrook, G.O, Hadden, J.M, Trinh, C.H, Carr, S.B, Wright, S.C. | Deposit date: | 2008-08-12 | Release date: | 2008-12-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the wild-type human BCL6 POZ domain. Acta Crystallogr.,Sect.F, 64, 2008
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4J8Z
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6C3L
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![BU of 6c3l by Molmil](/molmil-images/mine/6c3l) | Crystal structure of BCL6 BTB domain with compound 15f | Descriptor: | B-cell lymphoma 6 protein, N-[2-(1H-indol-3-yl)ethyl]-N'-{3-[(4-methylpiperazin-1-yl)methyl]-1-[2-(morpholin-4-yl)-2-oxoethyl]-1H-indol-6-yl}thiourea | Authors: | Linhares, B, Cheng, H, Cierpicki, T, Xue, F. | Deposit date: | 2018-01-10 | Release date: | 2019-01-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.46092153 Å) | Cite: | Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design. J.Med.Chem., 61, 2018
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6W69
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![BU of 6w69 by Molmil](/molmil-images/mine/6w69) | The structure of F64, S172A Keap1-BTB domain | Descriptor: | Kelch-like ECH-associated protein 1 | Authors: | Mena, E.L, Gee, C.L, Kuriyan, J, Rape, M. | Deposit date: | 2020-03-16 | Release date: | 2020-08-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Structural basis for dimerization quality control. Nature, 586, 2020
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6W68
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7AZW
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![BU of 7azw by Molmil](/molmil-images/mine/7azw) | Crystal structure of the MIZ1-BTB-domain | Descriptor: | GLYCEROL, Zinc finger and BTB domain-containing protein 17 isoform X1 | Authors: | Orth, B, Sander, B, Diederichs, K, Lorenz, S. | Deposit date: | 2020-11-17 | Release date: | 2021-06-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1. Structure, 29, 2021
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7AZX
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![BU of 7azx by Molmil](/molmil-images/mine/7azx) | Crystal structure of the MIZ1-BTB-domain in complex with a HUWE1-derived peptide | Descriptor: | E3 ubiquitin-protein ligase HUWE1, Zinc finger and BTB domain-containing protein 17 isoform X1 | Authors: | Orth, B, Sander, B, Diederichs, K, Lorenz, S. | Deposit date: | 2020-11-17 | Release date: | 2021-06-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1. Structure, 29, 2021
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3OHU
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![BU of 3ohu by Molmil](/molmil-images/mine/3ohu) | Crystal structure of the human Bach2 POZ domain, form I | Descriptor: | Transcription regulator protein BACH2 | Authors: | Rosbrook, G.O, Stead, M.A, Carr, S.B, Wright, S.C. | Deposit date: | 2010-08-18 | Release date: | 2011-11-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond. Acta Crystallogr.,Sect.D, 68, 2012
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3OHV
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![BU of 3ohv by Molmil](/molmil-images/mine/3ohv) | Crystal structure of the human Bach2 POZ domain, form II | Descriptor: | Transcription regulator protein BACH2 | Authors: | Rosbrook, G.O, Stead, M.A, Carr, S.B, Wright, S.C. | Deposit date: | 2010-08-18 | Release date: | 2011-11-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond. Acta Crystallogr.,Sect.D, 68, 2012
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7X4X
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![BU of 7x4x by Molmil](/molmil-images/mine/7x4x) | BTB domain of KEAP1 in complex with MEF | Descriptor: | 4-ethoxy-4-oxobutanoic acid, Kelch-like ECH-associated protein 1 | Authors: | Qu, L.Z. | Deposit date: | 2022-03-03 | Release date: | 2023-03-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates. Biochem.Biophys.Res.Commun., 605, 2022
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7X4W
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2IF5
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![BU of 2if5 by Molmil](/molmil-images/mine/2if5) | Structure of the POZ domain of human LRF, a master regulator of oncogenesis | Descriptor: | PRASEODYMIUM ION, Zinc finger and BTB domain-containing protein 7A | Authors: | Schubot, F.D, Waugh, D.S, Tropea, J. | Deposit date: | 2006-09-20 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the POZ domain of human LRF, a master regulator of oncogenesis. Biochem.Biophys.Res.Commun., 351, 2006
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8RIR
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![BU of 8rir by Molmil](/molmil-images/mine/8rir) | |
8RIT
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![BU of 8rit by Molmil](/molmil-images/mine/8rit) | |
2IHC
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![BU of 2ihc by Molmil](/molmil-images/mine/2ihc) | Crystal structure of the bric-a-brac (BTB) domain of human BACH1 | Descriptor: | Transcription regulator protein BACH1 | Authors: | Amos, A.L, Turnbull, A.P, Bunkoczi, G, Papagrigoriou, E, Gorrec, F, Umeano, C, Bullock, A, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-09-26 | Release date: | 2006-10-31 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Crystal structure of the bric-a-brac (BTB) domain of human BACH1 To be Published
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2NN2
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2PPI
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![BU of 2ppi by Molmil](/molmil-images/mine/2ppi) | Structure of the BTB (Tramtrack and Bric a brac) domain of human Gigaxonin | Descriptor: | Gigaxonin | Authors: | Amos, A, Turnbull, A.P, Tickle, J, Keates, T, Bullock, A, Savitsky, P, Burgess-Brown, N, Debreczeni, J.E, Ugochukwu, E, Umeano, C, Pike, A.C.W, Papagrigoriou, E, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-04-30 | Release date: | 2007-05-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the BTB (Tramtrack and Bric a brac) domain of human Gigaxonin. To be Published
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