8C78
Crystal structure of human BCL6 BTB domain in complex with compound CCT374705
Summary for 8C78
Entry DOI | 10.2210/pdb8c78/pdb |
Descriptor | B-cell lymphoma 6 protein, (2~{S})-10-[(3-chloranyl-2-fluoranyl-pyridin-4-yl)amino]-2-cyclopropyl-3,3-bis(fluoranyl)-7-methyl-2,4-dihydro-1~{H}-[1,4]oxazepino[2,3-c]quinolin-6-one, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | inhibitor, cancer, lymphoma, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 17268.97 |
Authors | Le Bihan, Y.-V.,van Montfort, R.L.M. (deposition date: 2023-01-13, release date: 2023-04-26, Last modification date: 2024-06-19) |
Primary citation | Harnden, A.C.,Davis, O.A.,Box, G.M.,Hayes, A.,Johnson, L.D.,Henley, A.T.,de Haven Brandon, A.K.,Valenti, M.,Cheung, K.J.,Brennan, A.,Huckvale, R.,Pierrat, O.A.,Talbot, R.,Bright, M.D.,Akpinar, H.A.,Miller, D.S.J.,Tarantino, D.,Gowan, S.,de Klerk, S.,McAndrew, P.C.,Le Bihan, Y.V.,Meniconi, M.,Burke, R.,Kirkin, V.,van Montfort, R.L.M.,Raynaud, F.I.,Rossanese, O.W.,Bellenie, B.R.,Hoelder, S. Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones. J.Med.Chem., 66:5892-5906, 2023 Cited by PubMed: 37026591DOI: 10.1021/acs.jmedchem.3c00155 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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