7BDE

HUMAN BCL6 BTB-DOMAIN IN COMPLEX WITH GSK137

Summary for 7BDE

• Entry DOI: 10.2210/pdb7bde/pdb
• Descriptor: Isoform 2 of B-cell lymphoma 6 protein, 5-[(5S,7R)-3-fluoranyl-7-(2-methylpyridin-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-5-yl]quinolin-2-amine, GLYCEROL, ... (5 entities in total)
• Functional Keywords: btb domain, b-cell lymphoma, transcriptional repression transcription, inhibitor, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 16101.44

Authors

Somers, D.O. (deposition date: 2020-12-21, release date: 2021-07-28, Last modification date: 2021-08-18)

• Primary citation: Pearce, A.C.,Bamford, M.J.,Barber, R.,Bridges, A.,Convery, M.A.,Demetriou, C.,Evans, S.,Gobbetti, T.,Hirst, D.J.,Holmes, D.S.,Hutchinson, J.P.,Jayne, S.,Lezina, L.,McCabe, M.T.,Messenger, C.,Morley, J.,Musso, M.C.,Scott-Stevens, P.,Manso, A.S.,Schofield, J.,Slocombe, T.,Somers, D.,Walker, A.L.,Wyce, A.,Zhang, X.P.,Wagner, S.D.; GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice.; J.Biol.Chem., 297:100928-100928, 2021; PubMed: 34274316; DOI: 10.1016/j.jbc.2021.100928

Experimental method

X-RAY DIFFRACTION (2.044 Å)