7BDE
HUMAN BCL6 BTB-DOMAIN IN COMPLEX WITH GSK137
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2 of B-cell lymphoma 6 protein | polymer | 135 | 15556.8 | 1 | UniProt (P41182) Pfam (PF00651) | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
| 2 | B (A) | 5-[(5S,7R)-3-fluoranyl-7-(2-methylpyridin-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-5-yl]quinolin-2-amine | non-polymer | 374.4 | 1 | Chemie (TEQ) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | E (A) | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A: 5 - 129 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Ser 4 | - | expression tag |
| Gln 8 | Cys 8 | engineered mutation |
| Arg 67 | Cys 67 | engineered mutation |
| Asn 84 | Cys 84 | engineered mutation |
| Asp 130 | - | expression tag |
| Tyr 131 | - | expression tag |
| Lys 132 | - | expression tag |
| Asp 133 | - | expression tag |
| Asp 134 | - | expression tag |
| Asp 135 | - | expression tag |
| Asp 136 | - | expression tag |
| Lys 137 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15556.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 544.6 | |
| All* | Total formula weight | 16101.4 |
