7BDE
HUMAN BCL6 BTB-DOMAIN IN COMPLEX WITH GSK137
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Isoform 2 of B-cell lymphoma 6 protein | polymer | 135 | 15556.8 | 1 | UniProt (P41182) Pfam (PF00651) In PDB | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
2 | A | 5-[(5S,7R)-3-fluoranyl-7-(2-methylpyridin-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-5-yl]quinolin-2-amine | non-polymer | 374.4 | 1 | Chemie (TEQ) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
5 | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A: 5 - 129 (UniProt: P41182)
PDB | External Database | Details |
---|---|---|
Gly 3 | - | expression tag |
Ser 4 | - | expression tag |
Gln 8 | Cys 8 | engineered mutation |
Arg 67 | Cys 67 | engineered mutation |
Asn 84 | Cys 84 | engineered mutation |
Asp 130 | - | expression tag |
Tyr 131 | - | expression tag |
Lys 132 | - | expression tag |
Asp 133 | - | expression tag |
Asp 134 | - | expression tag |
Asp 135 | - | expression tag |
Asp 136 | - | expression tag |
Lys 137 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 15556.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 544.6 | |
All* | Total formula weight | 16101.4 |