2KR9
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5N7E
| Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4). | Descriptor: | Breakpoint cluster region protein, Mb(Bcr-DH_4) | Authors: | Reckel, S, Reynaud, A, Pojer, F, Hantschel, O. | Deposit date: | 2017-02-20 | Release date: | 2017-12-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.647 Å) | Cite: | Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat Commun, 8, 2017
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1BY1
| DBL homology domain from beta-PIX | Descriptor: | PROTEIN (PIX) | Authors: | Aghazadeh, B, Zhu, K, Kubiseski, T.J, Liu, G.A, Pawson, T, Zheng, Y, Rosen, M.K. | Deposit date: | 1998-10-22 | Release date: | 1999-10-24 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structure and Mutagenesis of the Dbl Homology Domain Nat.Struct.Biol., 5, 1998
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1F5X
| NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN | Descriptor: | RHO-GEF VAV | Authors: | Aghazadeh, B, Rosen, M.K, Lowry, W.E, Huang, X.Y. | Deposit date: | 2000-06-18 | Release date: | 2000-09-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell(Cambridge,Mass.), 102, 2000
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8C7D
| Structure of the GEF Kalirin DH2 Domain | Descriptor: | Kalirin | Authors: | Callens, M.C, Thompson, A.P, Gray, J.L, Bountra, C, von Delft, F, Brennan, P.E. | Deposit date: | 2023-01-14 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structure-based alignment and analysis of RHO selectivity of RHO-DBL GTPase exchange factors to be published
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3EO2
| Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein | Descriptor: | Neuroepithelial cell-transforming gene 1 protein, UNKNOWN ATOM OR ION | Authors: | Nedyalkova, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-09-26 | Release date: | 2008-10-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein To be Published
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4D0O
| AKAP13 (AKAP-Lbc) DH domain | Descriptor: | A-KINASE ANCHOR PROTEIN 13 | Authors: | Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. | Deposit date: | 2014-04-29 | Release date: | 2014-05-21 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex. Biochem.J., 464, 2014
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4GYV
| Crystal structure of the DH domain of FARP2 | Descriptor: | FERM, RhoGEF and pleckstrin domain-containing protein 2 | Authors: | He, X, Zhang, X. | Deposit date: | 2012-09-05 | Release date: | 2013-03-13 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
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5N6R
| Solution structure of the Dbl-homology domain of Bcr-Abl | Descriptor: | Breakpoint cluster region protein | Authors: | Reckel, S, Lohr, F, Buchner, L, Guntert, P, Dotsch, V, Hantschel, O. | Deposit date: | 2017-02-16 | Release date: | 2017-12-27 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat Commun, 8, 2017
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1TXD
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1DBH
| DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1 | Descriptor: | PROTEIN (HUMAN SOS 1) | Authors: | Soisson, S.M, Kuriyan, J. | Deposit date: | 1998-12-17 | Release date: | 1998-12-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell(Cambridge,Mass.), 95, 1998
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4MT6
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3GF9
| Crystal structure of human Intersectin 2 RhoGEF domain | Descriptor: | Intersectin 2, UNKNOWN ATOM OR ION | Authors: | Shen, Y, Tong, Y, Tempel, W, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-02-26 | Release date: | 2009-03-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human Intersectin 2 RhoGEF domain To be Published
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2Z0Q
| Crystal structure of DH-PH domain of RhoGEF3(Xpln) | Descriptor: | Rho guanine nucleotide exchange factor 3, SULFATE ION | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-07 | Release date: | 2008-05-13 | Last modified: | 2012-12-12 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structure of the Rho-specific guanine nucleotide-exchange factor Xpln Acta Crystallogr.,Sect.F, 68, 2012
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4MT7
| Crystal structure of collybistin I | Descriptor: | Rho guanine nucleotide exchange factor 9 | Authors: | Schneeberger, D, Schindelin, H. | Deposit date: | 2013-09-19 | Release date: | 2014-08-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. Embo J., 33, 2014
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1RJ2
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5HZI
| Crystal structure of photoinhibitable Intersectin1 containing C450M mutant LOV2 domain | Descriptor: | FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1 | Authors: | Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. | Deposit date: | 2016-02-02 | Release date: | 2016-12-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Engineering extrinsic disorder to control protein activity in living cells. Science, 354, 2016
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5HZJ
| Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain | Descriptor: | FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1 | Authors: | Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. | Deposit date: | 2016-02-02 | Release date: | 2016-12-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Engineering extrinsic disorder to control protein activity in living cells. Science, 354, 2016
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3ODX
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3ODO
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3ODW
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3P6A
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2RGN
| Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | Authors: | Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. | Deposit date: | 2007-10-04 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science, 318, 2007
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7SYF
| Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1) | Descriptor: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera | Authors: | Lupton, C.J, Bayly-Jones, C, Ellisdon, A.M. | Deposit date: | 2021-11-24 | Release date: | 2022-07-27 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29, 2022
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2VRW
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