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8IL7	Structure of human soluble Adenylyl Cyclase in complex with lactate Descriptor: (2S)-2-HYDROXYPROPANOIC ACID, Adenylate cyclase type 10, GLYCEROL Authors: Li, Q.J, Li, Z.L, Gao, P. Deposit date: 2023-03-02 Release date: 2023-07-26 Last modified: 2024-08-14 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Lactate modulates iron metabolism by binding soluble adenylyl cyclase. Cell Metab., 35, 2023
2BW7	A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen Descriptor: 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE, ADENYLATE CYCLASE, CALCIUM ION, ... Authors: Steegborn, C, Litvin, T.N, Hess, K.C, Capper, A.B, Taussig, R, Buck, J, Levin, L.R, Wu, H. Deposit date: 2005-07-12 Release date: 2005-07-20 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: A Novel Mechanism for Adenylyl Cyclase Inhibition from the Crystal Structure of its Complex with Catechol Estrogen J.Biol.Chem., 280, 2005
3R5G	Crystal structure of the adenylyl cyclase CyaB from P. aeruginosa Descriptor: CyaB, GLYCEROL Authors: Topal, H, Steegborn, C. Deposit date: 2011-03-18 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structure and Regulation Mechanisms of the CyaB Adenylyl Cyclase from the Human Pathogen Pseudomonas aeruginosa. J.Mol.Biol., 416, 2012
7R65	Crystal structure of a bacterial cyclic UMP synthase from Burkholderia cepacia LK29 Descriptor: Adenylate/guanylate cyclase Authors: Morehouse, B.R, Kranzusch, P.J. Deposit date: 2021-06-22 Release date: 2021-10-13 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Cyclic CMP and cyclic UMP mediate bacterial immunity against phages. Cell, 184, 2021
5D0R	Crystal structure of human soluble Adenylyl Cyclase with the inhibitor bithionol Descriptor: 1,2-ETHANEDIOL, 2,2'-sulfanediylbis(4,6-dichlorophenol), ACETATE ION, ... Authors: Kleinboelting, S, Steegborn, C. Deposit date: 2015-08-03 Release date: 2016-03-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J.Biol.Chem., 291, 2016
8CO7	Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-09066 Descriptor: 1,2-ETHANEDIOL, 4-chloranyl-6-[1-methyl-4-(thiophen-2-ylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... Authors: Steegborn, C. Deposit date: 2023-02-27 Release date: 2024-01-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
3UVJ	Crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Guanylate cyclase soluble subunit alpha-3, ... Authors: Allerston, C.K, Berridge, G, Chalk, R, Cooper, C.D.O, Savitsky, P, Vollmar, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, von Delft, F, Gileadi, O, Structural Genomics Consortium (SGC) Deposit date: 2011-11-30 Release date: 2011-12-28 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Crystal structures of the catalytic domain of human soluble guanylate cyclase. Plos One, 8, 2013
4USW	Crystal structure of human soluble Adenylyl Cyclase with ATP Descriptor: ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ADENYLATE CYCLASE TYPE 10, ... Authors: Kleinboelting, S, Steegborn, C. Deposit date: 2014-07-13 Release date: 2014-07-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
4USU	Crystal structure of human soluble Adenylyl Cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate Descriptor: 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, CALCIUM ION, ... Authors: Kleinboelting, S, Steegborn, C. Deposit date: 2014-07-13 Release date: 2014-07-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
3MR7	Crystal Structure of Adenylate/Guanylate Cyclase/Hydrolase from Silicibacter pomeroyi Descriptor: Adenylate/guanylate cyclase/hydrolase, alpha/beta fold family Authors: Kim, Y, Li, H, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) Deposit date: 2010-04-28 Release date: 2010-06-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal Structure of Adenylate/Guanylate Cyclase/Hydrolase from Silicibacter pomeroyi To be Published
5IV4	Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor LRE1 Descriptor: 1,2-ETHANEDIOL, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... Authors: Kleinboelting, S, Steegborn, C. Deposit date: 2016-03-18 Release date: 2016-08-17 Last modified: 2022-11-30 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12, 2016
1FX4	STRUCTURE ANALYSIS OF ADENYLATE CYCLASES FROM TRYPANOSOMA BRUCEI IN THEIR MONOMERIC STATE Descriptor: MAGNESIUM ION, RECEPTOR-TYPE ADENYLATE CYCLASE GRESAG 4.3 Authors: Bieger, B, Essen, L.O. Deposit date: 2000-09-25 Release date: 2001-02-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state. EMBO J., 20, 2001
4UST	Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate resulting from soaking with GTP and Magnesium Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENYLATE CYCLASE TYPE 10, ... Authors: Kleinboelting, S, Steegborn, C. Deposit date: 2014-07-13 Release date: 2014-07-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
5IV3	Crystal structure of human soluble adenylyl cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate and the allosteric inhibitor LRE1 Descriptor: 1,2-ETHANEDIOL, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... Authors: Kleinboelting, S, Steegborn, C. Deposit date: 2016-03-18 Release date: 2016-08-17 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12, 2016
4USV	Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate resulting from soaking with ATP and Calcium Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENYLATE CYCLASE TYPE 10, ... Authors: Kleinboelting, S, Steegborn, C. Deposit date: 2014-07-13 Release date: 2014-07-30 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
2W01	Crystal structure of the guanylyl cyclase Cya2 Descriptor: ADENYLATE CYCLASE Authors: Rauch, A, Leipelt, M, Russwurm, M, Steegborn, C. Deposit date: 2008-08-08 Release date: 2008-09-30 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Crystal Structure of the Guanylyl Cyclase Cya2. Proc.Natl.Acad.Sci.USA, 105, 2008
1AB8	RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX Descriptor: ADENYLYL CYCLASE, FORSKOLIN Authors: Zhang, G, Hurley, J.H. Deposit date: 1997-02-04 Release date: 1997-05-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of the adenylyl cyclase catalytic core. Nature, 386, 1997
3ET6	The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase Descriptor: PHOSPHATE ION, Soluble guanylyl cyclase beta Authors: Winger, J.A, Derbyshire, E.R, Lamers, M.H, Marletta, M.A, Kuriyan, J. Deposit date: 2008-10-07 Release date: 2008-10-14 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.55 Å) Cite: The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. Bmc Struct.Biol., 8, 2008
2WZ1	STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLE GUANYLATE CYCLASE 1 BETA 3. Descriptor: 1,2-ETHANEDIOL, GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1 Authors: Allerston, C.K, Cooper, C.D.O, Muniz, J, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2009-11-23 Release date: 2009-12-01 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase. Plos One, 8, 2013
1FX2	STRUCTURAL ANALYSIS OF ADENYLATE CYCLASES FROM TRYPANOSOMA BRUCEI IN THEIR MONOMERIC STATE Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, RECEPTOR-TYPE ADENYLATE CYCLASE GRESAG 4.1, SULFATE ION Authors: Bieger, B, Essen, L.-O. Deposit date: 2000-09-25 Release date: 2001-02-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state. EMBO J., 20, 2001
4WP9	Crystal structure of Adenylyl cyclase MA1120 from Mycobacterium Avium bound to 2'5'-DD-3'-ATP, Calcium and Magnesium ion Descriptor: 2',5'-dideoxyadenosine 3'-(tetrahydrogen triphosphate), CALCIUM ION, MAGNESIUM ION, ... Authors: Bharambe, N.G, Barathy, D.V, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.382 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
4WP8	Crystal structure of Adenylyl cyclase Ma1120 from Mycobacterium Avium in complex with 2'5'-DD-3'-ATP and Manganese ion Descriptor: 2',5'-dideoxyadenosine 3'-(tetrahydrogen triphosphate), CHLORIDE ION, MANGANESE (II) ION, ... Authors: Barathy, D.V, Bharambe, N.G, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
5OYH	crystal structure of the catalytic core of a rhodopsin-guanylyl cyclase with converted specificity in complex with ATPalphaS Descriptor: ADENOSINE-5'-SP-ALPHA-THIO-TRIPHOSPHATE, CALCIUM ION, GLYCEROL, ... Authors: Broser, M, Scheib, U, Hegemann, P. Deposit date: 2017-09-09 Release date: 2018-06-06 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.249 Å) Cite: Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 angstrom structure of the adenylyl cyclase domain. Nat Commun, 9, 2018
4WP3	Crystal Structure of Adenylyl cyclase from Mycobacterium avium Ma1120 wild type Descriptor: CHLORIDE ION, Ma1120 Authors: Barathy, D.V, Bharambe, N.G, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
6AO9	Crystal structure of monomeric guanylyl cyclase domain of RhoGC fusion protein from the aquatic fungus Blastocladiella emersonii Descriptor: Bacterio-rhodopsin/guanylyl cyclase 1 fusion protein Authors: Prem Kumar, R, Oprian, D.D. Deposit date: 2017-08-15 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC. J. Biol. Chem., 292, 2017

 

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