5IV3
Crystal structure of human soluble adenylyl cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate and the allosteric inhibitor LRE1
Summary for 5IV3
Entry DOI | 10.2210/pdb5iv3/pdb |
Descriptor | Adenylate cyclase type 10, ACETATE ION, GLYCEROL, ... (10 entities in total) |
Functional Keywords | human soluble adenylyl cyclase hsac complex alpha, beta-methyleneadenosine-5'-triphosphate, allosteric inhibitor lre1, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Peripheral membrane protein ; Cytoplasmic side : Q96PN6 |
Total number of polymer chains | 1 |
Total formula weight | 55693.74 |
Authors | Kleinboelting, S.,Steegborn, C. (deposition date: 2016-03-18, release date: 2016-08-17, Last modification date: 2024-01-10) |
Primary citation | Ramos-Espiritu, L.,Kleinboelting, S.,Navarrete, F.A.,Alvau, A.,Visconti, P.E.,Valsecchi, F.,Starkov, A.,Manfredi, G.,Buck, H.,Adura, C.,Zippin, J.H.,van den Heuvel, J.,Glickman, J.F.,Steegborn, C.,Levin, L.R.,Buck, J. Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12:838-844, 2016 Cited by PubMed: 27547922DOI: 10.1038/nchembio.2151 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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