5IV3

Crystal structure of human soluble adenylyl cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate and the allosteric inhibitor LRE1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue ACT A 501

Chain	Residue
A	LYS95
A	HIS164
A	ASN333
A	LYS334
A	VAL335
A	GOL503
A	HOH642

---

site_id	AC2
Number of Residues	2
Details	binding site for residue ACT A 502

Chain	Residue
A	APC507
A	PEG509

---

site_id	AC3
Number of Residues	10
Details	binding site for residue GOL A 503

Chain	Residue
A	HIS19
A	PHE165
A	TYR268
A	LYS334
A	GLU403
A	ACT501
A	HOH636
A	HOH642
A	HOH706
A	HOH728

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL A 504

Chain	Residue
A	PRO356
A	ASP357
A	GLU358
A	LEU359
A	THR360
A	GLY434
A	ASN436
A	HOH729

---

site_id	AC5
Number of Residues	8
Details	binding site for residue GOL A 505

Chain	Residue
A	ILE24
A	HIS28
A	PHE29
A	LEU261
A	SER264
A	TYR268
A	HOH609
A	HOH667

---

site_id	AC6
Number of Residues	9
Details	binding site for residue LRI A 506

Chain	Residue
A	PHE45
A	ALA97
A	PHE165
A	LEU166
A	VAL167
A	VAL172
A	VAL175
A	PHE336
A	MET337

---

site_id	AC7
Number of Residues	19
Details	binding site for residue APC A 507

Chain	Residue
A	ASP47
A	ILE48
A	SER49
A	GLY50
A	PHE51
A	THR52
A	ALA97
A	ASP99
A	ARG176
A	GLN179
A	ASN180
A	PHE338
A	ASN412
A	ARG416
A	ACT502
A	CA508
A	HOH606
A	HOH646
A	HOH790

---

site_id	AC8
Number of Residues	5
Details	binding site for residue CA A 508

Chain	Residue
A	ASP47
A	ILE48
A	ASP99
A	APC507
A	HOH790

---

site_id	AC9
Number of Residues	7
Details	binding site for residue PEG A 509

Chain	Residue
A	GLY98
A	LEU345
A	VAL406
A	VAL411
A	ASN412
A	ACT502
A	HOH619

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 510

Chain	Residue
A	THR322
A	GLN331
A	ILE332

---

site_id	AD2
Number of Residues	4
Details	binding site for residue CL A 511

Chain	Residue
A	SER80
A	HIS398
A	THR399
A	HOH670

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00099

Chain	Residue	Details
A	ILE48
A	ASP99
A	ASP47

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:24567411, ECO:0000269|PubMed:24616449, ECO:0007744|PDB:4CLL, ECO:0007744|PDB:4OYZ

Chain	Residue	Details
A	VAL167
A	ARG176
A	MET337
A	LYS95

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:25040695, ECO:0000305|PubMed:24567411, ECO:0000305|PubMed:24616449, ECO:0007744|PDB:4USW

Chain	Residue	Details
A	VAL406
A	LYS144

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:24567411, ECO:0000305|PubMed:24616449, ECO:0000305|PubMed:25040695

Chain	Residue	Details
A	ASN412

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