5IV3
Crystal structure of human soluble adenylyl cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate and the allosteric inhibitor LRE1
エンティティ
| Entity ID | 鎖名 | 説明 | 種類 | 鎖長 | 化学式量 | 分子数 | データベース名(アクセス番号) | 由来する生物種 | エンティティの一般名 |
| 1 | A (A) | Adenylate cyclase type 10 | polymer | 475 | 54269.7 | 1 | UniProt (Q96PN6) Pfam (PF00211) | Homo sapiens (Human) | AH-related protein,Adenylate cyclase homolog,Germ cell soluble adenylyl cyclase,sAC,Testicular soluble adenylyl cyclase |
| 2 | B, C (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 3 | D, E, F (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | G (A) | 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine | non-polymer | 280.8 | 1 | Chemie (LRI) | |||
| 5 | H (A) | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | non-polymer | 505.2 | 1 | Chemie (APC) | |||
| 6 | I (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | J (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 8 | K (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 9 | L (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 10 | M (A) | water | water | 18.0 | 267 | Chemie (HOH) |
配列変更
A: 1 - 469 (UniProt: Q96PN6)
| PDB | 外部データベース | 詳細 |
|---|---|---|
| His 470 | - | expression tag |
| His 471 | - | expression tag |
| His 472 | - | expression tag |
| His 473 | - | expression tag |
| His 474 | - | expression tag |
| His 475 | - | expression tag |
配列ビューア
非対称単位の内容
| タンパク質・ 核酸鎖 | 鎖の数 | 1 |
| 化学式量合計 | 54269.7 | |
| タンパク質・ 核酸・ 糖鎖以外* | 分子数 | 11 |
| 化学式量合計 | 1424.1 | |
| 全て* | 化学式量合計 | 55693.7 |
