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5IV3

Crystal structure of human soluble adenylyl cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate and the allosteric inhibitor LRE1

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Adenylate cyclase type 10polymer47554269.71UniProt (Q96PN6)
Pfam (PF00211)
Homo sapiens (Human)AH-related protein,Adenylate cyclase homolog,Germ cell soluble adenylyl cyclase,sAC,Testicular soluble adenylyl cyclase
2B, C
(A)
ACETATE IONnon-polymer59.02Chemie (ACT)
3D, E, F
(A)
GLYCEROLnon-polymer92.13Chemie (GOL)
4G
(A)
6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diaminenon-polymer280.81Chemie (LRI)
5H
(A)
DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTERnon-polymer505.21Chemie (APC)
6I
(A)
CALCIUM IONnon-polymer40.11Chemie (CA)
7J
(A)
DI(HYDROXYETHYL)ETHERnon-polymer106.11Chemie (PEG)
8K
(A)
1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
9L
(A)
CHLORIDE IONnon-polymer35.51Chemie (CL)
10M
(A)
waterwater18.0267Chemie (HOH)
Sequence modifications
A: 1 - 469 (UniProt: Q96PN6)
PDBExternal DatabaseDetails
His 470-expression tag
His 471-expression tag
His 472-expression tag
His 473-expression tag
His 474-expression tag
His 475-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight54269.7
Non-Polymers*Number of molecules11
Total formula weight1424.1
All*Total formula weight55693.7
*Water molecules are not included.

239149

数据于2025-07-23公开中

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