4UBV
 
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7YVY
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5ONC
 | | Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch | | Descriptor: | CHLORIDE ION, Steroid 3-ketoacyl-CoA thiolase | | Authors: | Schaefer, C, Kuper, J, Sampson, N.S, Kisker, C. | | Deposit date: | 2017-08-03 | | Release date: | 2017-08-23 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.
ACS Infect Dis, 3, 2017
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1AFW
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4W61
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7FEA
 | | PY14 in complex with Col-D | | Descriptor: | (6~{R},7~{R},9~{E})-6,7-bis(oxidanyl)hexadeca-9,15-dien-11,13-diynoic acid, Acetyl-CoA C-acyltransferase | | Authors: | Lin, C.C, Ko, T.P, Huang, K.F, Yang, Y.L. | | Deposit date: | 2021-07-19 | | Release date: | 2022-07-27 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.
Commun Biol, 5, 2022
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4O99
 | | Crystal structure of Beta-ketothiolase (PhaA) from Ralstonia eutropha H16 | | Descriptor: | Acetyl-CoA acetyltransferase, GLYCEROL | | Authors: | Kim, E.J, Kim, J, Kim, S, Kim, K.J. | | Deposit date: | 2014-01-02 | | Release date: | 2014-12-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Crystal structure and biochemical characterization of PhaA from Ralstonia eutropha, a polyhydroxyalkanoate-producing bacterium.
Biochem.Biophys.Res.Commun., 452, 2014
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3GOA
 | | Crystal structure of the Salmonella typhimurium FadA 3-ketoacyl-CoA thiolase | | Descriptor: | 3-ketoacyl-CoA thiolase, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Anderson, S.M, Skarina, T, Onopriyenko, O, Wawrzak, Z, Papazisi, L, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2009-03-18 | | Release date: | 2009-03-31 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: |
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4WYS
 | | Crystal structure of thiolase from Escherichia coli | | Descriptor: | Acetyl-CoA acetyltransferase | | Authors: | Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. | | Deposit date: | 2014-11-18 | | Release date: | 2015-10-07 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum
Nat Commun, 6, 2015
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5ZQZ
 | | Structure of human mitochondrial trifunctional protein, tetramer | | Descriptor: | Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta | | Authors: | Liang, K, Li, N, Dai, J, Wang, X, Liu, P, Chen, X, Wang, C, Gao, N, Xiao, J. | | Deposit date: | 2018-04-20 | | Release date: | 2018-06-20 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-EM structure of human mitochondrial trifunctional protein
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4WYR
 | | Crystal structure of thiolase mutation (V77Q,N153Y,A286K) from Clostridium acetobutylicum | | Descriptor: | Acetyl-CoA acetyltransferase, DI(HYDROXYETHYL)ETHER, GLYCEROL | | Authors: | Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. | | Deposit date: | 2014-11-18 | | Release date: | 2015-10-07 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum
Nat Commun, 6, 2015
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6L2G
 | | Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase | | Descriptor: | Acetyl-CoA-acetyltransferase, putative | | Authors: | Zhang, Y, Wei, W, Raimi, O.G, Ferenbach, A.T, Fang, W. | | Deposit date: | 2019-10-03 | | Release date: | 2020-02-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.
Appl.Environ.Microbiol., 86, 2020
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5F0V
 | | X-ray crystal structure of a thiolase from Escherichia coli at 1.8 A resolution | | Descriptor: | 1,2-ETHANEDIOL, Acetyl-CoA acetyltransferase | | Authors: | Ithayaraja, M, Neelanjana, J, Wierenga, R, Savithri, H.S, Murthy, M.R.N. | | Deposit date: | 2015-11-28 | | Release date: | 2016-07-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of a thiolase from Escherichia coli at 1.8 angstrom resolution.
Acta Crystallogr.,Sect.F, 72, 2016
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6L2C
 | | Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase in complex with CoA | | Descriptor: | Acetyl-CoA-acetyltransferase, putative, COENZYME A | | Authors: | Zhang, Y, Wei, W, Raimi, O.G, Ferenbach, A.T, Fang, W. | | Deposit date: | 2019-10-03 | | Release date: | 2020-02-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.
Appl.Environ.Microbiol., 86, 2020
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7CW4
 | | Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579 | | Descriptor: | Acetyl-CoA acetyltransferase, GLYCEROL | | Authors: | Hong, J, Kim, K.J. | | Deposit date: | 2020-08-27 | | Release date: | 2020-10-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579.
Biochem.Biophys.Res.Commun., 533, 2020
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5ZRV
 | | Structure of human mitochondrial trifunctional protein, octamer | | Descriptor: | Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta | | Authors: | Liang, K, Li, N, Dai, J, Wang, X, Liu, P, Chen, X, Wang, C, Gao, N, Xiao, J. | | Deposit date: | 2018-04-25 | | Release date: | 2018-06-20 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (7.7 Å) | | Cite: | Cryo-EM structure of human mitochondrial trifunctional protein
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5F38
 | | X-ray crystal structure of a thiolase from Escherichia coli at 1.8 A resolution | | Descriptor: | 1,2-ETHANEDIOL, Acetyl-CoA acetyltransferase, COENZYME A, ... | | Authors: | Ithayaraja, M, Neelanjana, J, Wierenga, R, Savithri, H.S, Murthy, M.R.N. | | Deposit date: | 2015-12-02 | | Release date: | 2016-07-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of a thiolase from Escherichia coli at 1.8 angstrom resolution.
Acta Crystallogr.,Sect.F, 72, 2016
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3SS6
 | | Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase | | Descriptor: | Acetyl-CoA acetyltransferase, POTASSIUM ION, SULFATE ION | | Authors: | Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2011-07-07 | | Release date: | 2011-07-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase
TO BE PUBLISHED
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7CW5
 | | Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579 | | Descriptor: | Acetyl-CoA acetyltransferase, COENZYME A | | Authors: | Hong, J, Kim, K.J. | | Deposit date: | 2020-08-27 | | Release date: | 2020-10-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579.
Biochem.Biophys.Res.Commun., 533, 2020
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5XZ5
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3SVK
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5XYJ
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4UBT
 | | Structure of the C93S variant of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis in complex with a steroid and CoA. | | Descriptor: | (2S)-2-[(8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoic acid (non-preferred name), Acetyl-CoA acetyltransferase FadA5, CHLORIDE ION, ... | | Authors: | Schaefer, C.M, Kisker, C. | | Deposit date: | 2014-08-13 | | Release date: | 2014-12-17 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis.
Structure, 23, 2015
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4B3H
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4UBU
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