Structure of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis with an partially acetylated cysteine in complex with acetyl-CoA and CoA

Summary for 4UBV

DescriptorAcetyl-CoA acetyltransferase FadA5, ACETYL COENZYME *A, COENZYME A, ... (7 entities in total)
Functional Keywordspartially acetylated degradative thiolase, acetyl-coa, coa, transferase
Biological sourceMycobacterium tuberculosis H37Rv
Total number of polymer chains2
Total molecular weight89132.22
Schaefer, C.M.,Kisker, C. (deposition date: 2014-08-13, release date: 2014-12-17, Last modification date: 2015-01-14)
Primary citation
Schaefer, C.M.,Lu, R.,Nesbitt, N.M.,Schiebel, J.,Sampson, N.S.,Kisker, C.
FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis.
Structure, 23:21-33, 2015
PubMed: 25482540 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2014.10.010
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2091402.4%5.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload