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5ONC

Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch

Summary for 5ONC
Entry DOI10.2210/pdb5onc/pdb
Related4ubt 4ubu 4ubv 4ubw
DescriptorSteroid 3-ketoacyl-CoA thiolase, CHLORIDE ION (3 entities in total)
Functional Keywordsoxidative stress, cholesterol metabolism, lipid degradation, steroid metabolism, mycobacterium tuberculosis, biosynthetic protein
Biological sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains2
Total formula weight84870.71
Authors
Schaefer, C.,Kuper, J.,Sampson, N.S.,Kisker, C. (deposition date: 2017-08-03, release date: 2017-08-23, Last modification date: 2024-01-17)
Primary citationLu, R.,Schaefer, C.M.,Nesbitt, N.M.,Kuper, J.,Kisker, C.,Sampson, N.S.
Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.
ACS Infect Dis, 3:666-675, 2017
Cited by
PubMed: 28786661
DOI: 10.1021/acsinfecdis.7b00072
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.19 Å)
Structure validation

217705

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