5ONC
Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch
Summary for 5ONC
Entry DOI | 10.2210/pdb5onc/pdb |
Related | 4ubt 4ubu 4ubv 4ubw |
Descriptor | Steroid 3-ketoacyl-CoA thiolase, CHLORIDE ION (3 entities in total) |
Functional Keywords | oxidative stress, cholesterol metabolism, lipid degradation, steroid metabolism, mycobacterium tuberculosis, biosynthetic protein |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 2 |
Total formula weight | 84870.71 |
Authors | Schaefer, C.,Kuper, J.,Sampson, N.S.,Kisker, C. (deposition date: 2017-08-03, release date: 2017-08-23, Last modification date: 2024-01-17) |
Primary citation | Lu, R.,Schaefer, C.M.,Nesbitt, N.M.,Kuper, J.,Kisker, C.,Sampson, N.S. Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch. ACS Infect Dis, 3:666-675, 2017 Cited by PubMed: 28786661DOI: 10.1021/acsinfecdis.7b00072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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