5ONC
Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006635 | biological_process | fatty acid beta-oxidation |
| A | 0006707 | biological_process | cholesterol catabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0010124 | biological_process | phenylacetate catabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006635 | biological_process | fatty acid beta-oxidation |
| B | 0006707 | biological_process | cholesterol catabolic process |
| B | 0008202 | biological_process | steroid metabolic process |
| B | 0008203 | biological_process | cholesterol metabolic process |
| B | 0010124 | biological_process | phenylacetate catabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 401 |
| Chain | Residue |
| A | CYS118 |
| A | SER354 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | ARG212 |
| A | PHE215 |
| A | ARG216 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 403 |
| Chain | Residue |
| A | ASN315 |
| A | CYS377 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 404 |
| Chain | Residue |
| A | SER124 |
| A | HIS25 |
| A | ALA26 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 401 |
| Chain | Residue |
| B | SER354 |
Functional Information from PROSITE/UniProt
| site_id | PS00737 |
| Number of Residues | 17 |
| Details | THIOLASE_2 Thiolases signature 2. NvnGGaIAlGHPvGcTG |
| Chain | Residue | Details |
| A | ASN337-GLY353 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"source":"PubMed","id":"25482540","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4UBV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"25482540","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4UBV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"25482540","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25482540","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UBT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25482540","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UBV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25482540","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UBU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UBV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
