9PTI
 
 | |
6KZF
 | | Racemic X-ray Structure of Calcicludine | | Descriptor: | D-calcicludine, Kunitz-type serine protease inhibitor homolog calcicludine | | Authors: | Qu, Q, Gao, S, Liu, L. | | Deposit date: | 2019-09-24 | | Release date: | 2019-11-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy
Angew.Chem.Int.Ed.Engl., 59, 2020
|
|
5PTI
 | |
7PTI
 | |
6YHY
 | | A lid blocking mechanism of a cone snail toxin revealed at the atomic level | | Descriptor: | Conk-S1 | | Authors: | Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I. | | Deposit date: | 2020-03-31 | | Release date: | 2021-04-14 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | A Molecular Lid Mechanism of K + Channel Blocker Action Revealed by a Cone Peptide.
J.Mol.Biol., 433, 2021
|
|
8PTI
 | | CRYSTAL STRUCTURE OF A Y35G MUTANT OF BOVINE PANCREATIC TRYPSIN INHIBITOR | | Descriptor: | BOVINE PANCREATIC TRYPSIN INHIBITOR | | Authors: | Housset, D, Kim, K.-S, Fuchs, J, Woodward, C, Wlodawer, A. | | Deposit date: | 1990-12-17 | | Release date: | 1991-04-15 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor.
J.Mol.Biol., 220, 1991
|
|
6NAN
 | | NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition | | Descriptor: | Ixolaris | | Authors: | De Paula, V.S, Sgourakis, N.G, Francischetti, I.M.B, Almeida, F.C.L, Monteiro, R.Q, Valente, A.P. | | Deposit date: | 2018-12-06 | | Release date: | 2019-06-12 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition.
Blood, 134, 2019
|
|
5M4V
 | | X-ray structure of the mambaquaretin-1, a selective antagonist of the vasopressin type 2 receptor | | Descriptor: | CHLORIDE ION, Mambaquaretin-1, S-1,2-PROPANEDIOL | | Authors: | Stura, E.A, Vera, L, Ciolek, J, Mourier, G, Gilles, N. | | Deposit date: | 2016-10-19 | | Release date: | 2017-05-03 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
6F1F
 | | The methylene thioacetal BPTI (Bovine Pancreatic Trypsin Inhibitor) mutant structure | | Descriptor: | GLYCEROL, Pancreatic trypsin inhibitor, SULFATE ION | | Authors: | Lansky, S, Mousa, R, Metanis, N, Shoham, G. | | Deposit date: | 2017-11-21 | | Release date: | 2018-07-18 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.716 Å) | | Cite: | BPTI folding revisited: switching a disulfide into methylene thioacetal reveals a previously hidden path.
Chem Sci, 9, 2018
|
|
3WNY
 | |
5JB6
 | |
5EZD
 | | Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1 | | Descriptor: | ACETATE ION, Kunitz-type protease inhibitor 1, POTASSIUM ION | | Authors: | Hong, Z, Andreasen, P.A, Morth, J.P, Jensen, J.K. | | Deposit date: | 2015-11-26 | | Release date: | 2016-05-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.
J.Biol.Chem., 291, 2016
|
|
5XX5
 | | A BPTI-[5,55] variant with C14GA38I mutations | | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | | Authors: | Islam, M.M. | | Deposit date: | 2017-07-01 | | Release date: | 2018-07-04 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions.
Febs J., 2019
|
|
5XX2
 | | A BPTI-[5,55] variant with C14GA38L mutations | | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | | Authors: | Islam, M.M. | | Deposit date: | 2017-07-01 | | Release date: | 2018-07-04 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.12 Å) | | Cite: | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions.
Febs J., 2019
|
|
5XX4
 | | A BPTI-[5,55] variant with C14GA38K mutations | | Descriptor: | Pancreatic trypsin inhibitor, SULFATE ION | | Authors: | Islam, M.M. | | Deposit date: | 2017-07-01 | | Release date: | 2018-07-04 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions.
Febs J., 2019
|
|
5NMV
 | | Crystal structure of 2F22 Fab fragment against TFPI1 | | Descriptor: | Fab heavy chain, Fab light chain, GLYCEROL, ... | | Authors: | Svensson, L.A, Petersen, H.H. | | Deposit date: | 2017-04-07 | | Release date: | 2018-03-28 | | Last modified: | 2018-05-09 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Factor Xa and VIIa inhibition by tissue factor pathway inhibitor is prevented by a monoclonal antibody to its Kunitz-1 domain.
J. Thromb. Haemost., 16, 2018
|
|
6Q61
 | | Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | | Descriptor: | Kunitz-type conkunitzin-S1, SULFATE ION | | Authors: | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | | Deposit date: | 2018-12-10 | | Release date: | 2019-08-21 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Pore-modulating toxins exploit inherent slow inactivation to block K+channels.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6Q6C
 | | Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | | Descriptor: | 1,2-ETHANEDIOL, Kunitz-type conkunitzin-S1, NITRATE ION, ... | | Authors: | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | | Deposit date: | 2018-12-10 | | Release date: | 2019-08-21 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Pore-modulating toxins exploit inherent slow inactivation to block K+channels.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6PTI
 | |
4PTI
 | | THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS | | Descriptor: | TRYPSIN INHIBITOR | | Authors: | Huber, R, Kukla, D, Ruehlmann, A, Epp, O, Formanek, H, Deisenhofer, J, Steigemann, W. | | Deposit date: | 1982-09-27 | | Release date: | 1983-01-18 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
Acta Crystallogr.,Sect.B, 39, 1983
|
|
5JB7
 | |
5JB4
 | |
1FAN
 | | CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A | | Descriptor: | BOVINE PANCREATIC TRYPSIN INHIBITOR | | Authors: | Danishefsky, A.T, Wlodawer, A, Kim, K.-S, Tao, F, Woodward, C. | | Deposit date: | 1992-08-21 | | Release date: | 1993-10-31 | | Last modified: | 2019-08-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crevice-forming mutants in the rigid core of bovine pancreatic trypsin inhibitor: crystal structures of F22A, Y23A, N43G, and F45A.
Protein Sci., 2, 1993
|
|
5JB5
 | |
1G6X
 | | ULTRA HIGH RESOLUTION STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR (BPTI) MUTANT WITH ALTERED BINDING LOOP SEQUENCE | | Descriptor: | 1,2-ETHANEDIOL, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION | | Authors: | Addlagatta, A, Czapinska, H, Krzywda, S, Otlewski, J, Jaskolski, M. | | Deposit date: | 2000-11-08 | | Release date: | 2001-05-09 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (0.86 Å) | | Cite: | Ultrahigh-resolution structure of a BPTI mutant.
Acta Crystallogr.,Sect.D, 57, 2001
|
|
