8JME
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jme by Molmil](/molmil-images/mine/8jme) | |
8JMH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jmh by Molmil](/molmil-images/mine/8jmh) | |
7DHG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dhg by Molmil](/molmil-images/mine/7dhg) | Crystal structure of SARS-CoV-2 Orf9b complex with human TOM70 | Descriptor: | Mitochondrial import receptor subunit TOM70, ORF9b protein | Authors: | Gao, X, Zhu, K, Qin, B, Olieric, V, Wang, M, Cui, S. | Deposit date: | 2020-11-14 | Release date: | 2021-05-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions. Nat Commun, 12, 2021
|
|
7DDP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ddp by Molmil](/molmil-images/mine/7ddp) | Cryo-EM structure of human ACE2 and GX/P2V/2017 RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | Authors: | Niu, S, Wang, J, Wang, H.W, Qi, J.X, Wang, Q.H, Gao, G.F. | Deposit date: | 2020-10-29 | Release date: | 2021-05-19 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin. Embo J., 40, 2021
|
|
8IUF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8iuf by Molmil](/molmil-images/mine/8iuf) | Cryo-EM structure of Euglena gracilis super-complex I+III2+IV, composite | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Wu, M.C, Tian, H.T, He, Z.X, Hu, Y.Q, Zhou, L. | Deposit date: | 2023-03-24 | Release date: | 2024-02-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
|
|
7DDO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ddo by Molmil](/molmil-images/mine/7ddo) | Cryo-EM structure of human ACE2 and GD/1/2019 RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | Authors: | Niu, S, Wang, J, Wang, H.W, Qi, J.X, Wang, Q.H, Gao, G.F. | Deposit date: | 2020-10-29 | Release date: | 2021-05-19 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin. Embo J., 40, 2021
|
|
7CY0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cy0 by Molmil](/molmil-images/mine/7cy0) | Crystal structure of S185H mutant PET hydrolase from Ideonella sakaiensis | Descriptor: | ACETIC ACID, Poly(ethylene terephthalate) hydrolase | Authors: | Han, X, Liu, W.D, Zheng, Y.Y, Chen, C.C, Guo, R.T. | Deposit date: | 2020-09-03 | Release date: | 2021-05-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | General features to enhance enzymatic activity of poly(ethylene terephthalate) hydrolysis. Nat Catal, 4, 2021
|
|
7DJT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7djt by Molmil](/molmil-images/mine/7djt) | Human SARM1 inhibitory state bounded with inhibitor dHNN | Descriptor: | NAD(+) hydrolase SARM1, O3-methyl O5-(2-methylpropyl) 2,6-dimethyl-4-[2-(oxidanylamino)phenyl]pyridine-3,5-dicarboxylate | Authors: | Cai, Y, Zhang, H. | Deposit date: | 2020-11-21 | Release date: | 2021-05-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate. Elife, 10, 2021
|
|
8IUJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8iuj by Molmil](/molmil-images/mine/8iuj) | Cryo-EM structure of Euglena gracilis super-complex III2+IV2, composite | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Wu, M.C, Tian, H.T, He, Z.X, Hu, Y.Q, Zhou, L. | Deposit date: | 2023-03-24 | Release date: | 2024-02-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
|
|
8J3V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8j3v by Molmil](/molmil-images/mine/8j3v) | |
8JHZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jhz by Molmil](/molmil-images/mine/8jhz) | Cryo-EM structure of the TcsH-TMPRSS2 complex | Descriptor: | Hemorrhagic toxin, Transmembrane protease serine 2, ZINC ION | Authors: | Zhou, R, Liang, T, Zhan, X. | Deposit date: | 2023-05-25 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin. Nat Commun, 15, 2024
|
|
8JI0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ji0 by Molmil](/molmil-images/mine/8ji0) | |
7DF6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7df6 by Molmil](/molmil-images/mine/7df6) | Mouse Galectin-3 CRD in complex with novel tetrahydropyran-based thiodisaccharide mimic inhibitor | Descriptor: | (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-5-methoxy-6-[(3R,4R,5S)-4-oxidanyl-5-(4-pyrimidin-5-yl-1,2,3-triazol-1-yl)oxan-3-yl]sulfanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-3-ol, Galectin-3 | Authors: | Ghosh, K, Kumar, A. | Deposit date: | 2020-11-06 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors. J.Med.Chem., 64, 2021
|
|
7DSV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dsv by Molmil](/molmil-images/mine/7dsv) | Structure of a human NHE1-CHP1 complex under pH 6.5 | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Calcineurin B homologous protein 1, Sodium/hydrogen exchanger 1 | Authors: | Dong, Y, Gao, Y, Li, B, Zhang, X.C, Zhao, Y. | Deposit date: | 2021-01-03 | Release date: | 2021-06-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and mechanism of the human NHE1-CHP1 complex. Nat Commun, 12, 2021
|
|
7DSW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dsw by Molmil](/molmil-images/mine/7dsw) | Structure of a human NHE1-CHP1 complex under pH 7.5 | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Sodium/hydrogen exchanger 1 | Authors: | Dong, Y, Gao, Y, Li, B, Zhang, X.C, Zhao, Y. | Deposit date: | 2021-01-03 | Release date: | 2021-06-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure and mechanism of the human NHE1-CHP1 complex. Nat Commun, 12, 2021
|
|
7DF5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7df5 by Molmil](/molmil-images/mine/7df5) | Human Galectin-3 CRD in complex with novel tetrahydropyran-based thiodisaccharide mimic inhibitor | Descriptor: | (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-5-methoxy-6-[(3R,4R,5S)-4-oxidanyl-5-(4-pyrimidin-5-yl-1,2,3-triazol-1-yl)oxan-3-yl]sulfanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-3-ol, CHLORIDE ION, Galectin-3, ... | Authors: | Ghosh, K, Kumar, A. | Deposit date: | 2020-11-06 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors. J.Med.Chem., 64, 2021
|
|
8J74
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8j74 by Molmil](/molmil-images/mine/8j74) | Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, dimeric state | Descriptor: | (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium), CHOLESTEROL HEMISUCCINATE, HEXADECANE, ... | Authors: | Gao, Y, Qiu, Y, Zhao, Y. | Deposit date: | 2023-04-27 | Release date: | 2024-04-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Transport mechanism of presynaptic high-affinity choline uptake by CHT1. Nat.Struct.Mol.Biol., 31, 2024
|
|
7DSX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dsx by Molmil](/molmil-images/mine/7dsx) | Structure of a human NHE1-CHP1 complex under pH 7.5, bound by cariporide | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, Calcineurin B homologous protein 1, N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide, ... | Authors: | Dong, Y, Gao, Y, Li, B, Zhang, X.C, Zhao, Y. | Deposit date: | 2021-01-03 | Release date: | 2021-06-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure and mechanism of the human NHE1-CHP1 complex. Nat Commun, 12, 2021
|
|
7D0P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7d0p by Molmil](/molmil-images/mine/7d0p) | |
7D0Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7d0q by Molmil](/molmil-images/mine/7d0q) | |
7D0O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7d0o by Molmil](/molmil-images/mine/7d0o) | Crystal structure of human HBO1-BRPF2 in apo form | Descriptor: | 1,2-ETHANEDIOL, BRD1 protein, Histone acetyltransferase KAT7, ... | Authors: | Li, W, Ding, J. | Deposit date: | 2020-09-11 | Release date: | 2021-07-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | HBO1 is a versatile histone acyltransferase critical for promoter histone acylations. Nucleic Acids Res., 49, 2021
|
|
8ITX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8itx by Molmil](/molmil-images/mine/8itx) | Crystal structure of human Galectin-3 in complex with small molecule inhibitor | Descriptor: | 2-[(2S,3R,4S,5R,6R)-2-[2-[2,5-bis(chloranyl)phenyl]-5-methyl-1,2,4-triazol-3-yl]-4-[4-[4-chloranyl-3,5-bis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-5-oxidanyl-oxan-3-yl]oxyethanoic acid, CHLORIDE ION, Galectin-3, ... | Authors: | Jinal, S, Ghosh, K. | Deposit date: | 2023-03-23 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Discovery and Exploration of Monosaccharide Linked Dimers to Target Fibrosis To Be Published
|
|
7D0S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7d0s by Molmil](/molmil-images/mine/7d0s) | |
8ITZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8itz by Molmil](/molmil-images/mine/8itz) | Crystal structure of human Galectin-3 in complex with small molecule inhibitor | Descriptor: | 2-[(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-5-oxidanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-3-yl]oxyethanoic acid, CHLORIDE ION, Galectin-3, ... | Authors: | Jinal, S, Amit, K, Ghosh, K. | Deposit date: | 2023-03-23 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.22 Å) | Cite: | Discovery and Exploration of Monosaccharide Linked Dimers to Target Fibrosis To Be Published
|
|
7D0R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7d0r by Molmil](/molmil-images/mine/7d0r) | |