8E76
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![BU of 8e76 by Molmil](/molmil-images/mine/8e76) | Cryo-EM structure of Apo form ME3 | Descriptor: | NADP-dependent malic enzyme, mitochondrial | Authors: | Yu, X, Grell, T.A.J, Shaffer, P.L, Steele, R, Sharma, S, Thompson, A.A, Tresadern, G, Ortiz-Meoz, R.F, Mason, M, Gomez-Tamayo, J.C, Riley, D, Wagner, M.V, Wadia, J. | Deposit date: | 2022-08-23 | Release date: | 2023-02-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.51 Å) | Cite: | Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer. Heliyon, 8, 2022
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5V2C
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![BU of 5v2c by Molmil](/molmil-images/mine/5v2c) | RE-REFINEMENT OF CRYSTAL STRUCTURE OF PHOTOSYSTEM II COMPLEX | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | Authors: | Wang, J, Wiwczar, J.M, Brudvig, G.W. | Deposit date: | 2017-03-03 | Release date: | 2017-08-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Chlorophyll a with a farnesyl tail in thermophilic cyanobacteria. Photosyn. Res., 134, 2017
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5KHP
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![BU of 5khp by Molmil](/molmil-images/mine/5khp) | Tightening the Recognition of Tetravalent Zr and Th Complexes by the Siderophore-Binding Mammalian Protein Siderocalin for Theranostic Applications | Descriptor: | GLYCEROL, N,N'-(butane-1,4-diyl)bis(N-{3-[(2,3-dihydroxybenzene-1-carbonyl)amino]propyl}-2,3-dihydroxybenzamide), Neutrophil gelatinase-associated lipocalin, ... | Authors: | Rupert, P.B, Strong, R.K. | Deposit date: | 2016-06-15 | Release date: | 2017-04-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator-Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms. Inorg Chem, 55, 2016
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5UVK
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![BU of 5uvk by Molmil](/molmil-images/mine/5uvk) | Serial Millisecond Crystallography of Membrane and Soluble Protein Micro-crystals using Synchrotron Radiation | Descriptor: | C-phycocyanin alpha chain, C-phycocyanin beta chain, PHYCOCYANOBILIN | Authors: | Martin-Garcia, J.M, Conrad, C.E, Nelson, G, Stander, N, Zatsepin, N.A, Zook, J, Zhu, L, Geiger, J, Chun, E, Kissick, D, Hilgart, M.C, Ogata, C, Ishchenko, A, Nagaratnam, N, Roy-Chowdhury, S, Coe, J, Subramanian, G, Schaffer, A, James, D, Ketawala, G, Venugopalan, N, Xu, S, Corcoran, S, Ferguson, D, Weierstall, U, Spence, J.C.H, Cherezov, V, Fromme, P, Fischetti, R.F, Liu, W. | Deposit date: | 2017-02-20 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation. Iucrj, 4, 2017
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7LVZ
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![BU of 7lvz by Molmil](/molmil-images/mine/7lvz) | Crystal structure of ADO | Descriptor: | 2-aminoethanethiol dioxygenase, CHLORIDE ION, FE (II) ION, ... | Authors: | Bingman, C.A, Fernandez, R.L, Smith, R.W, Fox, B.G, Brunold, T.C. | Deposit date: | 2021-02-26 | Release date: | 2022-01-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin of the Large Substrate Scope of This Vital Mammalian Enzyme. Biochemistry, 60, 2021
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5AWO
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![BU of 5awo by Molmil](/molmil-images/mine/5awo) | Arthrobacter globiformis T6 isomalto-dextranse | Descriptor: | ACETATE ION, Isomaltodextranase, PHOSPHATE ION | Authors: | Tonozuka, T. | Deposit date: | 2015-07-08 | Release date: | 2015-09-09 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Crystal Structure and Mutational Analysis of Isomalto-dextranase, a Member of Glycoside Hydrolase Family 27 J.Biol.Chem., 290, 2015
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6VVA
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![BU of 6vva by Molmil](/molmil-images/mine/6vva) | |
8E78
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![BU of 8e78 by Molmil](/molmil-images/mine/8e78) | Cryo-EM structure of human ME3 in the presence of citrate | Descriptor: | NADP-dependent malic enzyme, mitochondrial | Authors: | Yu, X, Grell, T.A.J, Shaffer, P.L, Steele, R, Sharma, S, Thompson, A.A, Tresadern, G, Ortiz-Meoz, R.F, Mason, M, Gomez-Tamayo, J.C, Riley, D, Wagner, M.V, Wadia, J. | Deposit date: | 2022-08-23 | Release date: | 2023-02-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer. Heliyon, 8, 2022
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5V72
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![BU of 5v72 by Molmil](/molmil-images/mine/5v72) | Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase SMc04462 (SmGhrB) from Sinorhizobium meliloti in complex with citrate | Descriptor: | CHLORIDE ION, CITRIC ACID, GLYCEROL, ... | Authors: | Shabalin, I.G, Handing, K.B, Gasiorowska, O.A, Cooper, D.R, Matelska, D, Bonanno, J, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2017-03-17 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies. Biochemistry, 57, 2018
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8OI7
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![BU of 8oi7 by Molmil](/molmil-images/mine/8oi7) | Trichomonas vaginalis riboside hydrolase | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Inosine-uridine preferring nucleoside hydrolase family protein, ... | Authors: | Patrone, M, Stockman, B.J, Degano, M. | Deposit date: | 2023-03-22 | Release date: | 2023-08-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis. J.Biol.Chem., 299, 2023
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1L4Z
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![BU of 1l4z by Molmil](/molmil-images/mine/1l4z) | X-RAY CRYSTAL STRUCTURE OF THE COMPLEX OF MICROPLASMINOGEN WITH ALPHA DOMAIN OF STREPTOKINASE IN THE PRESENCE CADMIUM IONS | Descriptor: | CADMIUM ION, Plasminogen, Streptokinase | Authors: | Wakeham, N, Terzyan, S, Zhai, P, Loy, J.A, Tang, J, Zhang, X.C. | Deposit date: | 2002-03-06 | Release date: | 2002-12-11 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Effects of deletion of streptokinase residues 48-59 on plasminogen activation. PROTEIN ENG., 15, 2002
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3MX0
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![BU of 3mx0 by Molmil](/molmil-images/mine/3mx0) | Crystal Structure of EphA2 ectodomain in complex with ephrin-A5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-A receptor 2, ... | Authors: | Himanen, J.P, Yermekbayeva, L, Janes, P.W, Walker, J.R, Xu, K, Atapattu, L, Rajashankar, K.R, Mensinga, A, Lackmann, M, Nikolov, D.B, Dhe-Paganon, S. | Deposit date: | 2010-05-06 | Release date: | 2010-06-30 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.506 Å) | Cite: | Architecture of Eph receptor clusters. Proc.Natl.Acad.Sci.USA, 107, 2010
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5ZJD
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![BU of 5zjd by Molmil](/molmil-images/mine/5zjd) | Lactate dehydrogenase with NADH and MLA | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-lactate dehydrogenase A chain, MALONATE ION | Authors: | Han, C.W, Jang, S.B. | Deposit date: | 2018-03-20 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.394 Å) | Cite: | Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid. Cancers (Basel), 11, 2019
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7ZEQ
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![BU of 7zeq by Molmil](/molmil-images/mine/7zeq) | |
7ZCY
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![BU of 7zcy by Molmil](/molmil-images/mine/7zcy) | Sporosarcina pasteurii urease (SPU) co-crystallized in the presence of an Ebselen-derivative and bound to Se atoms | Descriptor: | 1,2-ETHANEDIOL, HYDROXIDE ION, N-(2-chloranyl-4-fluoranyl-phenyl)-2-selanyl-benzamide, ... | Authors: | Mazzei, L, Ciurli, S, Cianci, M. | Deposit date: | 2022-03-29 | Release date: | 2023-04-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action. J.Med.Chem., 66, 2023
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1RLF
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![BU of 1rlf by Molmil](/molmil-images/mine/1rlf) | STRUCTURE DETERMINATION OF THE RAS-BINDING DOMAIN OF THE RAL-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR RLF, NMR, 10 STRUCTURES | Descriptor: | RLF | Authors: | Esser, D, Bauer, B, Wolthuis, R.M.F, Wittinghofer, A, Cool, R.H, Bay, P. | Deposit date: | 1998-07-09 | Release date: | 1999-02-16 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf. Biochemistry, 37, 1998
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8OI9
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![BU of 8oi9 by Molmil](/molmil-images/mine/8oi9) | Trichomonas vaginalis riboside hydrolase in complex with 5-methyluridine | Descriptor: | 5-methyluridine, CALCIUM ION, Inosine-uridine preferring nucleoside hydrolase family protein, ... | Authors: | Patrone, M, Stockman, B.J, Degano, M. | Deposit date: | 2023-03-22 | Release date: | 2023-08-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis. J.Biol.Chem., 299, 2023
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6W29
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![BU of 6w29 by Molmil](/molmil-images/mine/6w29) | Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC013) | Descriptor: | 3,5-bis(fluoranyl)-~{N}-[3-[(4-methoxyphenyl)sulfamoyl]phenyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, ... | Authors: | Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. | Deposit date: | 2020-03-05 | Release date: | 2021-03-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. Acs Infect Dis., 7, 2021
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8OIA
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![BU of 8oia by Molmil](/molmil-images/mine/8oia) | Trichomonas vaginalis riboside hydrolase in complex with D-ribose | Descriptor: | CALCIUM ION, GLYCEROL, Inosine-uridine preferring nucleoside hydrolase family protein, ... | Authors: | Patrone, M, Stockman, B.J, Degano, M. | Deposit date: | 2023-03-22 | Release date: | 2023-08-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis. J.Biol.Chem., 299, 2023
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8OIC
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![BU of 8oic by Molmil](/molmil-images/mine/8oic) | Trichomonas vaginalis riboside hydrolase (His-tagged) | Descriptor: | BICINE, CALCIUM ION, Inosine-uridine preferring nucleoside hydrolase family protein | Authors: | Patrone, M, Stockman, B.J, Degano, M. | Deposit date: | 2023-03-22 | Release date: | 2023-08-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis. J.Biol.Chem., 299, 2023
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6W2N
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![BU of 6w2n by Molmil](/molmil-images/mine/6w2n) | Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC009) | Descriptor: | 3,5-bis(fluoranyl)-~{N}-[3-[(2-fluoranyl-4-methoxy-phenyl)sulfamoyl]phenyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, ... | Authors: | Mercaldi, G.F, Fagundes, M, Faria, J.N, Cordeiro, A.T. | Deposit date: | 2020-03-06 | Release date: | 2021-03-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box. Acs Infect Dis., 7, 2021
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8E5U
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![BU of 8e5u by Molmil](/molmil-images/mine/8e5u) | Co-crystal structure of Chaetomium glucosidase with compound 9 | Descriptor: | (2R,3R,4R,5S)-2-(hydroxymethyl)-1-(6-{2-nitro-4-[(1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl]anilino}hexyl)piperidine-3,4,5-triol, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Karade, S.S, Mariuzza, R.A. | Deposit date: | 2022-08-22 | Release date: | 2023-02-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity. J.Med.Chem., 66, 2023
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5B05
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![BU of 5b05 by Molmil](/molmil-images/mine/5b05) | Lysozyme (control experiment) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C, ... | Authors: | Kita, A, Morimoto, Y. | Deposit date: | 2015-10-28 | Release date: | 2016-01-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | An Effective Deuterium Exchange Method for Neutron Crystal Structure Analysis with Unfolding-Refolding Processes Mol Biotechnol., 58, 2016
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5ZO0
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![BU of 5zo0 by Molmil](/molmil-images/mine/5zo0) | Neutron structure of xylanase at pD5.4 | Descriptor: | Endo-1,4-beta-xylanase 2 | Authors: | Wan, Q, Li, Z.H. | Deposit date: | 2018-04-12 | Release date: | 2019-05-15 | Last modified: | 2023-11-22 | Method: | NEUTRON DIFFRACTION (1.648 Å) | Cite: | Neutron structure of xylanase at pD5.4 To be published
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8E3J
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![BU of 8e3j by Molmil](/molmil-images/mine/8e3j) | Co-crystal structure of Chaetomium glucosidase with compound 4 | Descriptor: | (2R,3R,4R,5S)-2-(hydroxymethyl)-1-{6-[2-nitro-4-(pyrimidin-2-yl)anilino]hexyl}piperidine-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Chaetomium alpha glucosidase, ... | Authors: | Karade, S.S, Mariuzza, R.A. | Deposit date: | 2022-08-17 | Release date: | 2023-02-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity. J.Med.Chem., 66, 2023
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