8E78

Cryo-EM structure of human ME3 in the presence of citrate

Summary for 8E78

Entry DOI	10.2210/pdb8e78/pdb
EMDB information	27937
Descriptor	NADP-dependent malic enzyme, mitochondrial (1 entity in total)
Functional Keywords	me1, me2, me3, nad(p)-dependent malic enzymes, integrated structural techniques, crystal structures, cryo-em structures, drug discovery, allosteric mechanism, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	268605.00
Authors	Yu, X.,Grell, T.A.J.,Shaffer, P.L.,Steele, R.,Sharma, S.,Thompson, A.A.,Tresadern, G.,Ortiz-Meoz, R.F.,Mason, M.,Gomez-Tamayo, J.C.,Riley, D.,Wagner, M.V.,Wadia, J. (deposition date: 2022-08-23, release date: 2023-02-08, Last modification date: 2024-06-19)
Primary citation	Grell, T.A.J.,Mason, M.,Thompson, A.A.,Gomez-Tamayo, J.C.,Riley, D.,Wagner, M.V.,Steele, R.,Ortiz-Meoz, R.F.,Wadia, J.,Shaffer, P.L.,Tresadern, G.,Sharma, S.,Yu, X. Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer. Heliyon, 8:e12392-e12392, 2022 Cited by PubMed: 36590518 DOI: 10.1016/j.heliyon.2022.e12392 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.77 Å)

Structure validation