7DGE
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![BU of 7dge by Molmil](/molmil-images/mine/7dge) | intermediate state of class C GPCR | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 1, nanobody | Authors: | Zhang, J.Y, Wu, L.J, Luo, F, Hua, T, Liu, Z.J. | Deposit date: | 2020-11-11 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Structural insights into the activation initiation of full-length mGlu1. Protein Cell, 12, 2021
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8TOT
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![BU of 8tot by Molmil](/molmil-images/mine/8tot) | ACE2-peptide2 complex crystal form 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Christie, M, Payne, R.J. | Deposit date: | 2023-08-03 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of High Affinity Cyclic Peptide Ligands for Human ACE2 with SARS-CoV-2 Entry Inhibitory Activity. Acs Chem.Biol., 19, 2024
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8TA3
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![BU of 8ta3 by Molmil](/molmil-images/mine/8ta3) | Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain Apo state with resolved N-terminal hairpin | Descriptor: | CHLORIDE ION, Chloride channel protein 2 | Authors: | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | Deposit date: | 2023-06-26 | Release date: | 2024-01-31 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.46 Å) | Cite: | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife, 12, 2024
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8TOU
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![BU of 8tou by Molmil](/molmil-images/mine/8tou) | ACE2-peptide 2 complex crystal form 3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Franck, C, Payne, R.J, Christie, M. | Deposit date: | 2023-08-04 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Discovery of High Affinity Cyclic Peptide Ligands for Human ACE2 with SARS-CoV-2 Entry Inhibitory Activity. Acs Chem.Biol., 19, 2024
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2IRV
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![BU of 2irv by Molmil](/molmil-images/mine/2irv) | Crystal structure of GlpG, a rhomboid intramembrane serine protease | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, DODECYL-BETA-D-MALTOSIDE, LAURYL DIMETHYLAMINE-N-OXIDE, ... | Authors: | Bibi, E, Fass, D, Ben-Shem, A. | Deposit date: | 2006-10-16 | Release date: | 2006-10-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for intramembrane proteolysis by rhomboid serine proteases. Proc.Natl.Acad.Sci.Usa, 104, 2007
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8UUA
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![BU of 8uua by Molmil](/molmil-images/mine/8uua) | Cryo-EM structure of the Listeria innocua 50S ribosomal subunit in complex with HflXr (structure III) | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, GTPase HflX, ... | Authors: | Seely, S.M, Basu, R.S, Gagnon, M.G. | Deposit date: | 2023-10-31 | Release date: | 2024-02-28 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
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2IC8
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![BU of 2ic8 by Molmil](/molmil-images/mine/2ic8) | Crystal structure of GlpG | Descriptor: | Protein glpG, nonyl beta-D-glucopyranoside | Authors: | Ha, Y. | Deposit date: | 2006-09-12 | Release date: | 2006-10-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of a rhomboid family intramembrane protease. Nature, 444, 2006
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2J3F
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![BU of 2j3f by Molmil](/molmil-images/mine/2j3f) | L-ficolin complexed to N-acetyl-D-galactosamine | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Garlatti, V, Gaboriaud, C. | Deposit date: | 2006-08-21 | Release date: | 2007-01-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins. Embo J., 26, 2007
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8V01
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![BU of 8v01 by Molmil](/molmil-images/mine/8v01) | |
2IDM
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![BU of 2idm by Molmil](/molmil-images/mine/2idm) | 2.00 A Structure of T87I/Y106W Phosphono-CheY | Descriptor: | ACETATE ION, Chemotaxis protein cheY | Authors: | Halkides, C.J, Haas, R.M, McAdams, K.A, Casper, E.S, Santarsiero, B.D, Mesecar, A.D. | Deposit date: | 2006-09-15 | Release date: | 2007-09-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides. Arch.Biochem.Biophys., 479, 2008
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8UWW
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![BU of 8uww by Molmil](/molmil-images/mine/8uww) | |
2J60
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![BU of 2j60 by Molmil](/molmil-images/mine/2j60) | H-ficolin complexed to D-fucose | Descriptor: | ACETATE ION, CALCIUM ION, FICOLIN-3, ... | Authors: | Garlatti, V, Gaboriaud, C. | Deposit date: | 2006-09-21 | Release date: | 2007-01-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins. Embo J., 26, 2007
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8UYD
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![BU of 8uyd by Molmil](/molmil-images/mine/8uyd) | |
2J95
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![BU of 2j95 by Molmil](/molmil-images/mine/2j95) | CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX | Descriptor: | 5'-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-2,2'-BITHIOPHENE-5-SULFONAMIDE, ACTIVATED FACTOR XA HEAVY CHAIN, ACTIVATED FACTOR XA LIGHT CHAIN, ... | Authors: | Chan, C, Borthwick, A.D, Brown, D, Campbell, M, Chaudry, L, Chung, C.W, Convery, M.A, Hamblin, J.N, Johnstone, L, Kelly, H.A, Kleanthous, S, Burns-Kurtis, C.L, Patikis, A, Patel, C, Pateman, A.J, Senger, S, Shah, G.P, Toomey, J.R, Watson, N.S, Weston, H.E, Whitworth, C, Young, R.J, Zhou, P. | Deposit date: | 2006-11-02 | Release date: | 2007-03-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Factor Xa Inhibitors: S1 Binding Interactions of a Series of N-{(3S)-1-[(1S)-1-Methyl-2-Morpholin-4-Yl-2-Oxoethyl]-2-Oxopyrrolidin-3-Yl}Sulfonamides. J.Med.Chem., 50, 2007
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2IWE
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![BU of 2iwe by Molmil](/molmil-images/mine/2iwe) | Structure of a cavity mutant (H117G) of Pseudomonas aeruginosa azurin | Descriptor: | 1,1'-HEXANE-1,6-DIYLBIS(1H-IMIDAZOLE), AZURIN, ZINC ION | Authors: | De Jongh, T.E, Van Roon, A.M.M, Prudencio, M, Ubbink, M, Canters, G.W. | Deposit date: | 2006-06-29 | Release date: | 2007-06-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Click-Chemistry with an Active Site Variant of Azurin Eur.J.Inorg.Chem., 2006, 2006
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8UI0
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7D6Y
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![BU of 7d6y by Molmil](/molmil-images/mine/7d6y) | eIF4E in Complex with a Disulphide-Free Autonomous VH Domain | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Eukaryotic translation initiation factor 4E, VH Domain (1C5), ... | Authors: | Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C. | Deposit date: | 2020-10-02 | Release date: | 2021-10-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.668 Å) | Cite: | Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways To Be Published
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8S86
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![BU of 8s86 by Molmil](/molmil-images/mine/8s86) | human PLD3 homodimer structure | Descriptor: | 5'-3' exonuclease PLD3 | Authors: | Lammens, K. | Deposit date: | 2024-03-05 | Release date: | 2024-05-15 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation. Immunity, 57, 2024
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2IJ5
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![BU of 2ij5 by Molmil](/molmil-images/mine/2ij5) | |
7F94
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![BU of 7f94 by Molmil](/molmil-images/mine/7f94) | Structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction intercellular channel with two conformationally different hemichannels | Descriptor: | A C-terminal deletion mutant of gap junction alpha-1 protein (Cx43-M257) | Authors: | Lee, H.J, Cha, H.J, Jeong, H, Lee, S.N, Lee, C.W, Woo, J.S. | Deposit date: | 2021-07-03 | Release date: | 2022-07-06 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM. Nat Commun, 14, 2023
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2IMF
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![BU of 2imf by Molmil](/molmil-images/mine/2imf) | 2-Hydroxychromene-2-carboxylate Isomerase: a Kappa Class Glutathione-S-Transferase from Pseudomonas putida | Descriptor: | 2-hydroxychromene-2-carboxylate isomerase, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, 4-(2-METHOXYPHENYL)-2-OXOBUT-3-ENOIC ACID, ... | Authors: | Thompson, L.C, Ladner, J.E, Codreanu, S.G, Harp, J, Gilliland, G.L, Armstrong, R.N. | Deposit date: | 2006-10-04 | Release date: | 2007-06-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | 2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida. Biochemistry, 46, 2007
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2INZ
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![BU of 2inz by Molmil](/molmil-images/mine/2inz) | Crystal Structure of Aldose Reductase complexed with 2-Hydroxyphenylacetic Acid | Descriptor: | (2-HYDROXYPHENYL)ACETIC ACID, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Harrison, D.H.T, Pape, E, Carlson, E, Brownlee, J.M. | Deposit date: | 2006-10-09 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes. Bioorg.Chem., 34, 2006
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8QNS
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![BU of 8qns by Molmil](/molmil-images/mine/8qns) | |
2I1J
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![BU of 2i1j by Molmil](/molmil-images/mine/2i1j) | Moesin from Spodoptera frugiperda at 2.1 angstroms resolution | Descriptor: | CHLORIDE ION, GLYCEROL, Moesin, ... | Authors: | Li, Q, Nance, M.R, Tesmer, J.J.G. | Deposit date: | 2006-08-14 | Release date: | 2006-12-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central alpha-Helical Domain. J.Mol.Biol., 365, 2007
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2HZL
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![BU of 2hzl by Molmil](/molmil-images/mine/2hzl) | Crystal structures of a sodium-alpha-keto acid binding subunit from a TRAP transporter in its closed forms | Descriptor: | PYRUVIC ACID, SODIUM ION, TRAP-T family sorbitol/mannitol transporter, ... | Authors: | Gonin, S, Arnoux, P, Pierru, B, Alonso, B, Sabaty, M, Pignol, D. | Deposit date: | 2006-08-09 | Release date: | 2007-04-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structures of an Extracytoplasmic Solute Receptor from a TRAP transporter in its open and closed forms reveal a helix-swapped dimer requiring a cation for alpha-keto acid binding. Bmc Struct.Biol., 7, 2007
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