8SFR
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![BU of 8sfr by Molmil](/molmil-images/mine/8sfr) | WT CRISPR-Cas12a post nontarget strand cleavage. | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (34-MER), DNA (5'-D(P*CP*TP*TP*CP*CP*GP*AP*TP*CP*TP*TP*TP*TP*AP*GP*TP*GP*AP*T)-3'), ... | Authors: | Strohkendl, I, Taylor, D.W. | Deposit date: | 2023-04-11 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | WT CRISPR-Cas12a post nontarget strand cleavage. To Be Published
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8SFJ
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![BU of 8sfj by Molmil](/molmil-images/mine/8sfj) | WT CRISPR-Cas12a with a 10bp R-loop | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*CP*AP*CP*TP*TP*AP*TP*CP*AP*CP*TP*AP*AP*AP*AP*GP*AP*TP*CP*GP*GP*AP*AP*G)-3'), DNA (5'-D(P*CP*TP*TP*CP*CP*GP*AP*TP*CP*TP*TP*TP*TP*AP*GP*TP*GP*AP*T)-3'), ... | Authors: | Strohkendl, I, Taylor, D.W. | Deposit date: | 2023-04-11 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | WT CRISPR-Cas12a with a 10bp R-loop To Be Published
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8SFH
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![BU of 8sfh by Molmil](/molmil-images/mine/8sfh) | |
8SFL
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![BU of 8sfl by Molmil](/molmil-images/mine/8sfl) | |
8SFP
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![BU of 8sfp by Molmil](/molmil-images/mine/8sfp) | |
5FSN
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![BU of 5fsn by Molmil](/molmil-images/mine/5fsn) | MTH1 substrate recognition: Complex with a aminomethylpyrimidinyl oxypropanol. | Descriptor: | 3-(2-AMINO-6-METHYL-PYRIMIDIN-4-YL)OXYPROPAN-1-OL, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, ACETATE ION, ... | Authors: | Nissink, J.W.M, Bista, M, Breed, J, Carter, N, Embrey, K, Read, J, Phillips, C, Winter, J.J. | Deposit date: | 2016-01-06 | Release date: | 2016-07-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Mth1 Substrate Recognition--an Example of Specific Promiscuity. Plos One, 11, 2016
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6YXX
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![BU of 6yxx by Molmil](/molmil-images/mine/6yxx) | State A of the Trypanosoma brucei mitoribosomal large subunit assembly intermediate | Descriptor: | 12S ribosomal RNA, 50S ribosomal protein L13, putative, ... | Authors: | Jaskolowski, M, Ramrath, D.J.F, Bieri, P, Niemann, M, Mattei, S, Calderaro, S, Leibundgut, M.A, Horn, E.K, Boehringer, D, Schneider, A, Ban, N. | Deposit date: | 2020-05-04 | Release date: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis. Mol.Cell, 79, 2020
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6YXY
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![BU of 6yxy by Molmil](/molmil-images/mine/6yxy) | State B of the Trypanosoma brucei mitoribosomal large subunit assembly intermediate | Descriptor: | 12S ribosomal RNA, ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Jaskolowski, M, Ramrath, D.J.F, Bieri, P, Niemann, M, Mattei, S, Calderaro, S, Leibundgut, M.A, Horn, E.K, Boehringer, D, Schneider, A, Ban, N. | Deposit date: | 2020-05-04 | Release date: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis. Mol.Cell, 79, 2020
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3DLH
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![BU of 3dlh by Molmil](/molmil-images/mine/3dlh) | Crystal structure of the guide-strand-containing Argonaute protein silencing complex | Descriptor: | ACETIC ACID, Argonaute, DNA (5'-D(DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DAP*DGP*DGP*DTP*DTP*DGP*DTP*DAP*DTP*DAP*DGP*DT)-3'), ... | Authors: | Wang, Y, Sheng, G, Patel, D.J. | Deposit date: | 2008-06-27 | Release date: | 2008-09-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of the guide-strand-containing argonaute silencing complex. Nature, 456, 2008
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8E9A
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![BU of 8e9a by Molmil](/molmil-images/mine/8e9a) | Crystal structure of AsfvPolX in complex with 10-23 DNAzyme and Mg | Descriptor: | DNA/RNA (52-MER), MAGNESIUM ION, Repair DNA polymerase X, ... | Authors: | Cramer, E.R, Robart, A.R, Kaya, A.I. | Deposit date: | 2022-08-26 | Release date: | 2023-06-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structure of a 10-23 deoxyribozyme exhibiting a homodimer conformation. Commun Chem, 6, 2023
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6I85
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![BU of 6i85 by Molmil](/molmil-images/mine/6i85) | Influenza A nucleoprotein docked into the 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 5. | Descriptor: | Influenza A nucleoprotein, Nucleoprotein | Authors: | Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J. | Deposit date: | 2018-11-19 | Release date: | 2020-01-29 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (24 Å) | Cite: | Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism. Nat Microbiol, 5, 2020
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7RLO
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![BU of 7rlo by Molmil](/molmil-images/mine/7rlo) | Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral protein NSs | Descriptor: | Non-structural protein NS-S, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | Authors: | Wang, L, Schoof, M, Cogan, J, Lawrence, R, Boone, M, Wuerth, J, Frost, M, Walter, P. | Deposit date: | 2021-07-26 | Release date: | 2021-12-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Commun, 12, 2021
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6FFA
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![BU of 6ffa by Molmil](/molmil-images/mine/6ffa) | FMDV Leader protease bound to substrate ISG15 | Descriptor: | GLYCEROL, Lbpro, SULFATE ION, ... | Authors: | Swatek, K.N, Pruneda, J.N, Komander, D. | Deposit date: | 2018-01-05 | Release date: | 2018-02-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2HBJ
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![BU of 2hbj by Molmil](/molmil-images/mine/2hbj) | Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain | Descriptor: | Exosome complex exonuclease RRP6 | Authors: | Midtgaard, S.F, Assenholt, J, Jonstrup, A.T, Van, L.B, Jensen, T.H, Brodersen, D.E. | Deposit date: | 2006-06-14 | Release date: | 2006-07-25 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain. Proc.Natl.Acad.Sci.Usa, 103, 2006
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5FSI
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![BU of 5fsi by Molmil](/molmil-images/mine/5fsi) | MTH1 substrate recognition: Complex with 8-oxo-dGTP. | Descriptor: | 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | Authors: | Nissink, J.W.M, Bista, M, Breed, J, Carter, N, Embrey, K, Read, J, Phillips, C, Winter, J.J. | Deposit date: | 2016-01-06 | Release date: | 2016-07-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Mth1 Substrate Recognition--an Example of Specific Promiscuity. Plos One, 11, 2016
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5ABJ
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![BU of 5abj by Molmil](/molmil-images/mine/5abj) | Structure of Coxsackievirus A16 in complex with GPP3 | Descriptor: | 1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE, CHLORIDE ION, SODIUM ION, ... | Authors: | De Colibus, L, Wang, X, Tijsma, A, Neyts, J, Spyrou, J.A.B, Ren, J, Grimes, J.M, Puerstinger, G, Leyssen, P, Fry, E.E, Rao, Z, Stuart, D.I. | Deposit date: | 2015-08-06 | Release date: | 2015-09-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structure Elucidation of Coxsackievirus A16 in Complex with Gpp3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses. Plos Pathog., 11, 2015
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6DUQ
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![BU of 6duq by Molmil](/molmil-images/mine/6duq) | Structure of a Rho-NusG KOW domain complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Berger, J.M, Lawson, M.R. | Deposit date: | 2018-06-21 | Release date: | 2018-09-05 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein. Mol. Cell, 71, 2018
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5FSK
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![BU of 5fsk by Molmil](/molmil-images/mine/5fsk) | MTH1 substrate recognition: Complex with 8-oxo-dGTP. | Descriptor: | 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, 8-OXO-ADENOSINE-5'-TRIPHOSPHATE, ACETATE ION | Authors: | Nissink, J.W.M, Bista, M, Breed, J, Carter, N, Embrey, K, Read, J, Phillips, C, Winter, J.J. | Deposit date: | 2016-01-06 | Release date: | 2016-07-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Mth1 Substrate Recognition--an Example of Specific Promiscuity. Plos One, 11, 2016
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5FSM
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![BU of 5fsm by Molmil](/molmil-images/mine/5fsm) | MTH1 substrate recognition: Complex with a methylbenzimidazolyl acetamide. | Descriptor: | 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, ACETATE ION, DIMETHYL SULFOXIDE, ... | Authors: | Nissink, J.W.M, Bista, M, Breed, J, Carter, N, Embrey, K, Read, J, Phillips, C, Winter, J.J. | Deposit date: | 2016-01-06 | Release date: | 2016-07-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Mth1 Substrate Recognition--an Example of Specific Promiscuity. Plos One, 11, 2016
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2HBK
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![BU of 2hbk by Molmil](/molmil-images/mine/2hbk) | Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain; Protein in complex with Mn | Descriptor: | Exosome complex exonuclease RRP6, MANGANESE (II) ION | Authors: | Midtgaard, S.F, Assenholt, J, Jonstrup, A.T, Van, L.B, Jensen, T.H, Brodersen, D.E. | Deposit date: | 2006-06-14 | Release date: | 2006-07-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain. Proc.Natl.Acad.Sci.Usa, 103, 2006
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3LLH
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![BU of 3llh by Molmil](/molmil-images/mine/3llh) | Crystal structure of the first dsRBD of TAR RNA-binding protein 2 | Descriptor: | MALONATE ION, RISC-loading complex subunit TARBP2 | Authors: | Yamashita, S, Kawazoe, M, Takemoto, C, Sekine, S, Wakiyama, M, Yokoyama, S. | Deposit date: | 2010-01-29 | Release date: | 2010-12-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | The structures of dsRBDs of human TRBP To be Published
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2VGM
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![BU of 2vgm by Molmil](/molmil-images/mine/2vgm) | |
2VGN
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![BU of 2vgn by Molmil](/molmil-images/mine/2vgn) | Structure of S. cerevisiae Dom34, a translation termination-like factor involved in RNA quality control pathways and interacting with Hbs1 (SelenoMet-labeled protein) | Descriptor: | DOM34, GLYCEROL, PHOSPHATE ION | Authors: | Graille, M, Chaillet, M, Van Tilbeurgh, H. | Deposit date: | 2007-11-14 | Release date: | 2008-01-22 | Last modified: | 2021-03-17 | Method: | X-RAY DIFFRACTION (2.505 Å) | Cite: | Structure of Yeast Dom34: A Protein Related to Translation Termination Factor Erf1 and Involved in No-Go Decay. J.Biol.Chem., 283, 2008
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6I54
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![BU of 6i54 by Molmil](/molmil-images/mine/6i54) | Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 2. | Descriptor: | Influenza virus nucleoprotein, Nucleoprotein | Authors: | Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J. | Deposit date: | 2018-11-12 | Release date: | 2019-11-13 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism. Nat Microbiol, 5, 2020
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3QGH
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![BU of 3qgh by Molmil](/molmil-images/mine/3qgh) | |