8UMO
 
 | | Murine CD94-NKG2A receptor in complex with Qa-1b presenting AMAPRTLLL | | Descriptor: | BROMIDE ION, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | | Authors: | MacLachlan, B.J, Rossjohn, J, Vivian, J.P. | | Deposit date: | 2023-10-18 | | Release date: | 2024-01-17 | | Last modified: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of the murine CD94-NKG2A receptor in complex with Qa-1 b presenting an MHC-I leader peptide.
Febs J., 291, 2024
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6AVG
 | | Crystal structure of the KFJ37 TCR-NY-ESO-1-HLA-B*07:02 complex | | Descriptor: | ALA-PRO-ARG-GLY-PRO-HIS-GLY-GLY-ALA-ALA-SER-GLY-LEU, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | | Authors: | Gully, B.S, Gras, S, Rossjohn, J. | | Deposit date: | 2017-09-02 | | Release date: | 2018-02-28 | | Last modified: | 2018-03-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide.
Nat Commun, 9, 2018
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3DMM
 | | Crystal structure of the CD8 alpha beta/H-2Dd complex | | Descriptor: | Beta-2 microglobulin, H-2 class I histocompatibility antigen, D-D alpha chain, ... | | Authors: | Wang, R, Natarajan, K, Margulies, D.H. | | Deposit date: | 2008-07-01 | | Release date: | 2009-07-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of the CD8alphabeta/MHC class i interaction: focused recognition orients CD8beta to a T cell proximal position.
J.Immunol., 183, 2009
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4E41
 | | Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4 | | Descriptor: | HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ... | | Authors: | Deng, L, Langley, R.J, Wang, Q, Topalian, S.L, Mariuzza, R.A. | | Deposit date: | 2012-03-11 | | Release date: | 2012-08-29 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Proc.Natl.Acad.Sci.USA, 2012
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6MFF
 | | HLA-DQ2-glia-omega1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DQ alpha 1 chain, ... | | Authors: | Petersen, J, Ciacchi, L, Rossjohn, J. | | Deposit date: | 2018-09-10 | | Release date: | 2018-11-21 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes.
J. Biol. Chem., 294, 2019
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3FTG
 | | Crystal Structure of H2Db in complex with NP366-N3A variant peptide from influenza | | Descriptor: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-B alpha chain, ... | | Authors: | Gras, S, Guillonneau, C, Rossjohn, J. | | Deposit date: | 2009-01-12 | | Release date: | 2009-12-29 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold.
Plos Pathog., 6, 2010
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7LFN
 | | Structure of Hyperglycosylated Human IgG1 Fc (Fc267_329) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc267_329), alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Fields, J.K, Sundberg, E.J. | | Deposit date: | 2021-01-17 | | Release date: | 2021-01-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions
To Be Published
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7LF5
 | | Structure of Hyperglycosylated Human IgG1 Fc (Fc267) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc267), alpha-L-fucopyranose, ... | | Authors: | Fields, J.K, Sundberg, E.J. | | Deposit date: | 2021-01-15 | | Release date: | 2021-01-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions
To Be Published
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6V19
 | | immune receptor complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta 72,74cit69-81, GLYCEROL, ... | | Authors: | Lim, J.J, Rossjohn, J. | | Deposit date: | 2019-11-20 | | Release date: | 2020-11-25 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Sci Immunol, 6, 2021
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1FYT
 | | CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA-T CELL RECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS II MOLECULE, HLA-DR1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ HA1 PEPTIDE CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, ... | | Authors: | Hennecke, J, Carfi, A, Wiley, D.C. | | Deposit date: | 2000-10-03 | | Release date: | 2000-11-08 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1.
EMBO J., 19, 2000
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1I9J
 | | TESTOSTERONE COMPLEX STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI-TESTOSTERONE FAB FRAGMENT | | Descriptor: | RECOMBINANT MONOCLONAL ANTI-TESTOSTERONE FAB FRAGMENT HEAVY CHAIN, RECOMBINANT MONOCLONAL ANTI-TESTOSTERONE FAB FRAGMENT LIGHT CHAIN, TESTOSTERONE | | Authors: | Valjakka, J, Takkinenz, K, Teerinen, T, Soderlund, H, Rouvinen, J. | | Deposit date: | 2001-03-20 | | Release date: | 2002-03-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural insights into steroid hormone binding: the crystal structure of a recombinant anti-testosterone Fab fragment in free and testosterone-bound forms.
J.Biol.Chem., 277, 2002
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1IAO
 | | CLASS II MHC I-AD IN COMPLEX WITH OVALBUMIN PEPTIDE 323-339 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC CLASS II I-AD | | Authors: | Scott, C.A, Peterson, P.A, Teyton, L, Wilson, I.A. | | Deposit date: | 1998-03-13 | | Release date: | 1998-11-04 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues.
Immunity, 8, 1998
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1MIM
 | | IGG FAB FRAGMENT (CD25-BINDING) | | Descriptor: | CHIMERIC SDZ CHI621 | | Authors: | Mikol, V. | | Deposit date: | 1995-12-04 | | Release date: | 1997-05-15 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of the fab fragment of SDZ CHI621: a chimeric antibody against CD25.
Acta Crystallogr.,Sect.D, 52, 1996
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3BEW
 | | 10mer Crystal Structure of chicken MHC class I haplotype B21 | | Descriptor: | 10-mer from Tubulin beta-6 chain, Beta-2-microglobulin, Major histocompatibility complex class I glycoprotein haplotype B21 | | Authors: | Koch, M, Camp, S, Collen, T, Avila, D, Salomonsen, J, Wallny, H.J, van Hateren, A, Hunt, L, Jacob, J.P, Johnston, F, Marston, D.A, Shaw, I, Dunbar, P.R, Cerundolo, V, Jones, E.Y, Kaufman, J. | | Deposit date: | 2007-11-20 | | Release date: | 2008-01-01 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structures of an MHC class I molecule from b21 chickens illustrate promiscuous Peptide binding
Immunity, 27, 2007
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2CDG
 | | Structure and binding kinetics of three different human CD1d-alpha- Galactosylceramide-specific T cell receptors (TCR 5B) | | Descriptor: | TCR 5E | | Authors: | Gadola, S.D, Koch, M, Marles-Wright, J, Lissin, N.M, Sheperd, D, Matulis, G, Harlos, K, Villiger, P.M, Stuart, D.I, Jakobsen, B.K, Cerundolo, V, Jones, E.Y. | | Deposit date: | 2006-01-23 | | Release date: | 2006-03-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structrue and Binding Kinetics of Three Different Human Cd1D-Alpha-Galactosylceramide-Specific T Cell Receptors
J.Exp.Med., 203, 2006
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1C12
 | | INSIGHT IN ODORANT PERCEPTION: THE CRYSTAL STRUCTURE AND BINDING CHARACTERISTICS OF ANTIBODY FRAGMENTS DIRECTED AGAINST THE MUSK ODORANT TRASEOLIDE | | Descriptor: | PROTEIN (ANTIBODY FRAGMENT FAB), TRAZEOLIDE | | Authors: | Langedijk, A.C, Spinelli, S, Anguille, C, Hermans, P, Nederlof, J, Butenandt, J, Honegger, A, Cambillau, C, Pluckthun, A. | | Deposit date: | 1999-07-20 | | Release date: | 1999-08-14 | | Last modified: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Insight into odorant perception: the crystal structure and binding characteristics of antibody fragments directed against the musk odorant traseolide.
J.Mol.Biol., 292, 1999
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1MPA
 | | BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS | | Descriptor: | CADMIUM ION, MN12H2 IGG2A-KAPPA, PORA P1.16 PEPTIDE FLUORESCEIN CONJUGATE | | Authors: | Van Den Elsen, J.M.H, Herron, J.N, Kroon, J, Gros, P. | | Deposit date: | 1997-02-26 | | Release date: | 1997-09-04 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide.
Proteins, 29, 1997
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3KPR
 | | Crystal Structure of the LC13 TCR in complex with HLA B*4405 bound to EEYLKAWTF a mimotope | | Descriptor: | Beta-2-microglobulin, EEYLKAWTF, mimotope peptide, ... | | Authors: | Macdonald, W.A, Chen, Z, Gras, S, Archbold, J.K, Tynan, F.E, Clements, C.S, Bharadwaj, M, Kjer-Nielsen, L, Saunders, P.M, Wilce, M.C, Crawford, F, Stadinsky, B, Jackson, D, Brooks, A.G, Purcell, A.W, Kappler, J.W, Burrows, S.R, Rossjohn, J, McCluskey, J. | | Deposit date: | 2009-11-16 | | Release date: | 2009-12-22 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | T cell allorecognition via molecular mimicry.
Immunity, 31, 2009
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7XQU
 | | The structure of FLA-E*00301/EM-FECV-10 | | Descriptor: | Beta-2-microglobulin, MHC class I antigen, peptide from Nucleoprotein | | Authors: | Qiao, P.W, Yue, C, Peng, W.Y, Liu, K.F, Huo, S.T, Zhang, D, Chai, Y, Qi, J.X, Sun, Z.Y, Gao, G.F, Liu, W.J, Wu, G.Z. | | Deposit date: | 2022-05-08 | | Release date: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Analysis of the characteristics of feline major histocompatibility complex class I molecules cross-presenting coronavirus peptides
To Be Published
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3UTT
 | | 1E6-A*0201-ALWGPDPAAA Complex, Triclinic | | Descriptor: | 1E6 TCR Alpha Chain, 1E6 TCR Beta Chain, Beta-2-microglobulin, ... | | Authors: | Rizkallah, P.J, Cole, D.K, Sewell, A.K, Bulek, A.M, Rossjohn, J, Gras, S. | | Deposit date: | 2011-11-26 | | Release date: | 2012-01-25 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
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3RWF
 | | Rhesus macaque MHC class I molecule Mamu-B*17-QW9 | | Descriptor: | Beta-2-microglobulin, Major histocompatibility complex class I, Nef QW9 peptide from Protein Nef | | Authors: | Wu, Y, Gao, F, Liu, J, Qi, J.X, Price, D.A, Gao, G.F. | | Deposit date: | 2011-05-09 | | Release date: | 2012-03-21 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus
J.Immunol., 187, 2011
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1H3P
 | | STRUCTURAL CHARACTERISATION OF A MONOCLONAL ANTIBODY SPECIFIC FOR THE PRES1 REGION OF THE HEPATITIS B VIRUS | | Descriptor: | ANTIBODY FAB FRAGMENT | | Authors: | Pizarro, J.C, Vulliez-Le-normand, B, Riottot, M.M, Budkowska, A, Bentley, G.A. | | Deposit date: | 2002-09-12 | | Release date: | 2002-09-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and Functional Characterisation of a Monoclonal Antibody Specific for the Pres1 Region of Hepatitis B Virus
FEBS Lett., 509, 2001
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3DVG
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1AXS
 | | MATURE OXY-COPE CATALYTIC ANTIBODY WITH HAPTEN | | Descriptor: | (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL, CADMIUM ION, OXY-COPE CATALYTIC ANTIBODY | | Authors: | Mundorff, E.C, Ulrich, H.D, Stevens, R.C. | | Deposit date: | 1997-10-20 | | Release date: | 1998-02-04 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The interplay between binding energy and catalysis in the evolution of a catalytic antibody.
Nature, 389, 1997
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8VDD
 | | Crystal structure of Proinsulin C-peptide bound to HLA-DQ8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, MHC class II HLA-DQ-alpha chain, ... | | Authors: | Tran, T.M, Lim, J.J, Loh, T.Y, Mannering, I.S, Rossjohn, J, Reid, H.H. | | Deposit date: | 2023-12-14 | | Release date: | 2024-08-07 | | Last modified: | 2024-08-14 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8.
J.Biol.Chem., 2024
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