8JF7
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8SVZ
| Structure of the Francisella response regulator KdpE receiver domain | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Two-component response regulator | Authors: | Milton, M.E, Cavanagh, J. | Deposit date: | 2023-05-17 | Release date: | 2024-06-12 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Insights into DNA-binding motifs and mechanisms of Francisella tularensis novicida two-component system response regulator proteins QseB, KdpE, and BfpR. Biochem.Biophys.Res.Commun., 722, 2024
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8JER
| Structure of Acipimox-GPR109A-G protein complex | Descriptor: | 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | Deposit date: | 2023-05-16 | Release date: | 2024-03-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. Nat Commun, 15, 2024
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8JEU
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8JET
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8JEK
| Cryo-EM Structure of K-ferricyanide Oxidized Membrane-bound Fructose Dehydrogenase from Gluconobacter japonicus | Descriptor: | FE3-S4 CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, Fructose dehydrogenase cytochrome subunit, ... | Authors: | Suzuki, Y, Miyata, T, Makino, F, Tanaka, H, Namba, K, Sowa, K, Kitazumi, Y, Shirai, O. | Deposit date: | 2023-05-16 | Release date: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Essential Insight of Direct Electron Transfer-Type Bioelectrocatalysis by Membrane-Bound d-Fructose Dehydrogenase with Structural Bioelectrochemistry. Acs Catalysis, 13, 2023
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8JEJ
| Cryo-EM Structure of Na-dithionite Reduced Membrane-bound Fructose Dehydrogenase from Gluconobacter japonicus | Descriptor: | FE3-S4 CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, Fructose dehydrogenase cytochrome subunit, ... | Authors: | Suzuki, Y, Miyata, T, Makino, F, Tanaka, H, Namba, K, Sowa, K, Kitazumi, Y, Shirai, O. | Deposit date: | 2023-05-16 | Release date: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Essential Insight of Direct Electron Transfer-Type Bioelectrocatalysis by Membrane-Bound d-Fructose Dehydrogenase with Structural Bioelectrochemistry. Acs Catalysis, 13, 2023
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8P2F
| Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane in post-translocational state | Descriptor: | 1,4-DIAMINOBUTANE, 16S ribosomal RNA, 2-[(3~{R},4~{S},5~{S},8~{S},9~{S},10~{S},11~{R},13~{S},14~{S},16~{S})-16-acetyloxy-4,8,10,14-tetramethyl-3,11-bis(oxidanyl)-1,2,3,4,5,6,7,9,11,12,13,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5-cyclopentyl-pentanoic acid, ... | Authors: | Gonzalez-Lopez, A, Selmer, M. | Deposit date: | 2023-05-16 | Release date: | 2024-05-01 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.44 Å) | Cite: | Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane. Sci Rep, 14, 2024
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8P2G
| Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane with a tRNA in pe/E chimeric state | Descriptor: | 1,4-DIAMINOBUTANE, 16S ribosomal RNA, 2-[(3~{R},4~{S},5~{S},8~{S},9~{S},10~{S},11~{R},13~{S},14~{S},16~{S})-16-acetyloxy-4,8,10,14-tetramethyl-3,11-bis(oxidanyl)-1,2,3,4,5,6,7,9,11,12,13,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5-cyclopentyl-pentanoic acid, ... | Authors: | Gonzalez-Lopez, A, Selmer, M. | Deposit date: | 2023-05-16 | Release date: | 2024-05-01 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.02 Å) | Cite: | Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane. Sci Rep, 14, 2024
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8P2H
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8P2Q
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8JEC
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8SV9
| Crystal structure of ULK1 kinase domain with inhibitor MR-2088 | Descriptor: | (4P)-4-[(2P)-2-(1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(2,2,2-trifluoroethyl)thiophene-2-carboxamide, 1,2-ETHANEDIOL, SULFATE ION, ... | Authors: | Schonbrunn, E, Sun, L. | Deposit date: | 2023-05-15 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties. Eur.J.Med.Chem., 266, 2024
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8P25
| Solution structure of a chimeric U2AF2 RRM2 / FUBP1 N-Box | Descriptor: | Splicing factor U2AF 65 kDa subunit,Far upstream element-binding protein 1 | Authors: | Hipp, C, Sattler, M. | Deposit date: | 2023-05-14 | Release date: | 2023-07-26 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | FUBP1 is a general splicing factor facilitating 3' splice site recognition and splicing of long introns. Mol.Cell, 83, 2023
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8SUY
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8JD1
| Cryo-EM structure of mGlu2-mGlu3 heterodimer in Rco state | Descriptor: | CHOLESTEROL, GLUTAMIC ACID, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JCW
| Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode I) | Descriptor: | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JD2
| Cryo-EM structure of G protein-free mGlu2-mGlu3 heterodimer in Acc state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JCZ
| Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and LY2389575 (dimerization mode III) | Descriptor: | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JCV
| Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode II) | Descriptor: | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JD6
| Cryo-EM structure of Gi1-bound metabotropic glutamate receptor mGlu4 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-3, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JCY
| Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and LY2389575 (dimerization mode I) | Descriptor: | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JD0
| Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of NAM563 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(1-methylpyrazol-4-yl)-7-[[(2~{S})-2-(trifluoromethyl)morpholin-4-yl]methyl]quinoline-2-carboxamide, CHOLESTEROL, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JCU
| Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode I) | Descriptor: | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JD5
| Cryo-EM structure of Gi1-bound mGlu2-mGlu4 heterodimer | Descriptor: | 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine, ... | Authors: | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2023-05-12 | Release date: | 2023-06-21 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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