8JCY

Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and LY2389575 (dimerization mode I)

Summary for 8JCY

• Entry DOI: 10.2210/pdb8jcy/pdb
• EMDB information: 36169
• Descriptor: Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, Metabotropic glutamate receptor 3,Serine/threonine-protein kinase mTOR, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: complex structure, mglu2-3 heterodimer, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 225967.61

Authors

Wang, X.,Wang, M.,Xu, T.,Feng, Y.,Han, S.,Lin, S.,Zhao, Q.,Wu, B. (deposition date: 2023-05-12, release date: 2023-06-21, Last modification date: 2023-10-18)

• Primary citation: Wang, X.,Wang, M.,Xu, T.,Feng, Y.,Shao, Q.,Han, S.,Chu, X.,Xu, Y.,Lin, S.,Zhao, Q.,Wu, B.; Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.; Cell Res., 33:762-774, 2023; PubMed: 37286794; DOI: 10.1038/s41422-023-00830-2

Experimental method

ELECTRON MICROSCOPY (2.9 Å)