8JCU

Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode I)

Summary for 8JCU

• Entry DOI: 10.2210/pdb8jcu/pdb
• EMDB information: 36165
• Descriptor: Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, Metabotropic glutamate receptor 3,Serine/threonine-protein kinase mTOR, 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, ... (4 entities in total)
• Functional Keywords: complex structure, mglu2-3 heterodimer, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 223261.03

Authors

Wang, X.,Wang, M.,Xu, T.,Feng, Y.,Zhao, Q.,Wu, B. (deposition date: 2023-05-12, release date: 2023-06-21, Last modification date: 2023-10-18)

• Primary citation: Wang, X.,Wang, M.,Xu, T.,Feng, Y.,Shao, Q.,Han, S.,Chu, X.,Xu, Y.,Lin, S.,Zhao, Q.,Wu, B.; Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.; Cell Res., 33:762-774, 2023; PubMed: 37286794; DOI: 10.1038/s41422-023-00830-2

Experimental method

ELECTRON MICROSCOPY (2.8 Å)