8A2S
| Cryo-EM structure of F-actin in the Mg2+-ADP-Pi nucleotide state. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Oosterheert, W, Klink, B.U, Belyy, A, Pospich, S, Raunser, S. | Deposit date: | 2022-06-06 | Release date: | 2022-08-10 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.22 Å) | Cite: | Structural basis of actin filament assembly and aging. Nature, 611, 2022
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8A2R
| Cryo-EM structure of F-actin in the Mg2+-ADP-BeF3- nucleotide state. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Oosterheert, W, Klink, B.U, Belyy, A, Pospich, S, Raunser, S. | Deposit date: | 2022-06-06 | Release date: | 2022-08-10 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.17 Å) | Cite: | Structural basis of actin filament assembly and aging. Nature, 611, 2022
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8UZ1
| Straight actin filament from Arp2/3 branch junction sample (ADP-BeFx) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Chavali, S.S, Chou, S.Z, Sindelar, C.V. | Deposit date: | 2023-11-14 | Release date: | 2024-01-31 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex. Nat Commun, 15, 2024
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8TRN
| Actin 1 from T. gondii in filaments bound to MgADP and jasplakinolide | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, Jasplakinolide, ... | Authors: | Hvorecny, K.L, Sladewski, T.E, Heaslip, A.T, Kollman, J.M. | Deposit date: | 2023-08-09 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover. Nat Commun, 15, 2024
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8TRM
| Actin 1 from T. gondii in filaments bound to MgADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION | Authors: | Hvorecny, K.L, Sladewski, T.E, Heaslip, A.T, Kollman, J.M. | Deposit date: | 2023-08-09 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover. Nat Commun, 15, 2024
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8V30
| Smooth Muscle Gamma Actin (ACTG2) Filament Mutant R40C | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, gamma-enteric smooth muscle, ... | Authors: | Palmer, N.J, Carman, P.J, Ceron, R.H, Dominguez, R. | Deposit date: | 2023-11-25 | Release date: | 2024-05-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | Molecular mechanisms linking missense ACTG2 mutations to visceral myopathy. Sci Adv, 10, 2024
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8V2O
| Cryo-EM Structure of Wildtype Smooth Muscle Gamma Actin (ACTG2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, gamma-enteric smooth muscle, ... | Authors: | Palmer, N.J, Carman, P.J, Ceron, R.H, Dominguez, R. | Deposit date: | 2023-11-23 | Release date: | 2024-05-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Molecular mechanisms linking missense ACTG2 mutations to visceral myopathy. Sci Adv, 10, 2024
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8V2Z
| Cryo-EM Structure of Smooth Muscle Gamma Actin (ACTG2) Mutant R257C | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, gamma-enteric smooth muscle, ... | Authors: | Palmer, N.J, Carman, P.J, Ceron, R.H, Dominguez, R. | Deposit date: | 2023-11-25 | Release date: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | Smooth Muscle Gamma Actin (ACTG2) Filament Mutant R257C To Be Published
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8UZ0
| Straight actin filament from Arp2/3 branch junction sample (ADP) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Chavali, S.S, Chou, S.Z, Sindelar, C.V. | Deposit date: | 2023-11-14 | Release date: | 2024-01-31 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex. Nat Commun, 15, 2024
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9B3R
| The structure of human cardiac F-actin | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | Authors: | Doran, M.H, Sousa, D, Rynkiewicz, M.J, Lehman, W, Cammarato, A. | Deposit date: | 2024-03-20 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of human cardiac actin To Be Published
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9B3Q
| The structure of the human cardiac F-actin mutant A331P | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | Authors: | Doran, M.H, Sousa, D, Rynkiewicz, M.J, Lehman, W, Cammarato, A. | Deposit date: | 2024-03-20 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of human cardiac actin To Be Published
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7PM3
| Cryo-EM structure of young JASP-stabilized F-actin (central 3er) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Pospich, S, Sweeney, H.L, Houdusse, A, Raunser, S. | Deposit date: | 2021-09-01 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism. Elife, 10, 2021
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7QIM
| In situ structure of nebulin bound to actin filament in skeletal sarcomere | Descriptor: | ACTS protein, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wang, Z, Grange, M, Pospich, S, Wagner, T, Kho, A.L, Gautel, M, Raunser, S. | Deposit date: | 2021-12-15 | Release date: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin. Science, 375, 2022
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7Q8B
| Leishmania major actin filament in ADP-Pi state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION, ... | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | Deposit date: | 2021-11-11 | Release date: | 2022-05-18 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite. Nat Commun, 13, 2022
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7Q8C
| Leishmania major actin filament in ADP-state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | Deposit date: | 2021-11-11 | Release date: | 2022-05-18 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite. Nat Commun, 13, 2022
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7LRG
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1MDU
| Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (GS-1) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | Authors: | Dawson, J.F, Sablin, E.P, Spudich, J.A, Fletterick, R.J. | Deposit date: | 2002-08-07 | Release date: | 2003-01-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing J.Biol.Chem., 278, 2003
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4V0U
| The crystal structure of ternary PP1G-PPP1R15B and G-actin complex | Descriptor: | ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. | Deposit date: | 2014-09-18 | Release date: | 2015-03-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (7.88 Å) | Cite: | G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases. Elife, 4, 2015
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2YJF
| Oligomeric assembly of actin bound to MRTF-A | Descriptor: | ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Mouilleron, S, Langer, C.A, Guettler, S, McDonald, N.Q, Treisman, R. | Deposit date: | 2011-05-19 | Release date: | 2011-07-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator. Sci Signal, 4, 2011
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5H53
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5UBO
| Mical-oxidized Actin complex with Gelsolin Segment 1 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Grintsevich, E.E, Sawaya, M.R, Reisler, E. | Deposit date: | 2016-12-21 | Release date: | 2017-12-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Catastrophic disassembly of actin filaments via Mical-mediated oxidation. Nat Commun, 8, 2017
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5TGC
| Structure of the hetero-trimer of Rtt102-Arp7/9 bound to ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-like protein ARP9, Actin-related protein 7, ... | Authors: | Turegun, B, Dominguez, R. | Deposit date: | 2016-09-27 | Release date: | 2017-09-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.245 Å) | Cite: | Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase. Commun Biol, 1, 2018
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3UKR
| Crystal structure of Bos taurus Arp2/3 complex with bound inhibitor CK-666 | Descriptor: | 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ... | Authors: | Nolen, B.J, Han, M. | Deposit date: | 2011-11-09 | Release date: | 2013-02-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structural characterization and computer-aided optimization of a small-molecule inhibitor of the Arp2/3 complex, a key regulator of the actin cytoskeleton. Chemmedchem, 7, 2012
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7Y8R
| The nucleosome-bound human PBAF complex | Descriptor: | ACTB protein (Fragment), ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2, ... | Authors: | Wang, L, Yu, J, Yu, Z, Wang, Q, He, S, Xu, Y. | Deposit date: | 2022-06-24 | Release date: | 2022-12-07 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structure of nucleosome-bound human PBAF complex. Nat Commun, 13, 2022
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3UKU
| Structure of Arp2/3 complex with bound inhibitor CK-869 | Descriptor: | (2S)-2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, ACTIN-LIKE PROTEIN 2, ACTIN-LIKE PROTEIN 3, ... | Authors: | Nolen, B.J, Han, M. | Deposit date: | 2011-11-09 | Release date: | 2013-02-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structure of Arp2/3 complex with bound inhibitor CK-869 To be Published
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