PDB: 45176 resultsInfo pagesStatus searchChemie searchBIRD

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2WPA	Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, N-{6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1,4,5,6-TETRAHYDROPYRROLO[3,4-C]PYRAZOL-3-YL}-3-METHYLBUTANAMIDE, ... Authors: Brasca, M.G, Albanese, C, Alzani, R, Amici, R, Avanzi, N, Ballinari, D, Bischoff, J, Borghi, D, Casale, E, Croci, V, Fiorentini, F, Isacchi, A, Mercurio, C, Nesi, M, Orsini, P, Pastori, W, Pesenti, E, Pevarello, P, Roussel, P, Varasi, M, Volpi, D, Vulpetti, A, Ciomei, M. Deposit date: 2009-08-03 Release date: 2010-02-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Optimization of 6,6-Dimethyl Pyrrolo[3,4-C]Pyrazoles: Identification of Pha-793887, a Potent Cdk Inhibitor Suitable for Intravenous Dosing. Bioorg.Med.Chem., 18, 2010
4V48	Real space refined coordinates of the 30S and 50S subunits fitted into the low resolution cryo-EM map of the initiation-like state of E. coli 70S ribosome Descriptor: 16S RIBOSOMAL RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... Authors: Gao, H, Sengupta, J, Valle, M, Korostelev, A, Eswar, N, Stagg, S.M, Van Roey, P, Agrawal, R.K, Harvey, S.T, Sali, A, Chapman, M.S, Frank, J. Deposit date: 2003-05-06 Release date: 2014-07-09 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (11.5 Å) Cite: Study of the structural dynamics of the E. coli 70S ribosome using real space refinement Cell(Cambridge,Mass.), 113, 2003
4V4G	Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y. Descriptor: 16S ribosomal RNA, 23S RIBOSOMAL RNA, 30S ribosomal protein S10, ... Authors: Vila-Sanjurjo, A, Schuwirth, B.S, Hau, C.W, Cate, J.H. Deposit date: 2004-10-06 Release date: 2014-07-09 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (11.5 Å) Cite: Structural basis for the control of translation initiation during stress. Nat.Struct.Mol.Biol., 11, 2004
3EG6	Structure of WDR5 bound to MLL1 peptide Descriptor: MLL-1 peptide, SULFATE ION, WD repeat-containing protein 5 Authors: Patel, A, Dharmarajan, V, Cosgrove, M.S. Deposit date: 2008-09-10 Release date: 2008-09-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. J.Biol.Chem., 283, 2008
4V4B	Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map. Descriptor: 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S11, ... Authors: Spahn, C.M, Gomez-Lorenzo, M.G, Grassucci, R.A, Jorgensen, R, Andersen, G.R, Beckmann, R, Penczek, P.A, Ballesta, J.P.G, Frank, J. Deposit date: 2004-01-06 Release date: 2014-07-09 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (11.7 Å) Cite: Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation. Embo J., 23, 2004
4V6C	Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Zhang, W, Dunkle, J.A, Cate, J.H.D. Deposit date: 2009-06-27 Release date: 2014-07-09 Last modified: 2014-12-10 Method: X-RAY DIFFRACTION (3.19 Å) Cite: Structures of the ribosome in intermediate States of ratcheting. Science, 325, 2009
4V6W	Structure of the D. melanogaster 80S ribosome Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 2S ribosomal RNA, ... Authors: Anger, A.M, Armache, J.-P, Berninghausen, O, Habeck, M, Subklewe, M, Wilson, D.N, Beckmann, R. Deposit date: 2013-02-27 Release date: 2014-07-09 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (6 Å) Cite: Structures of the human and Drosophila 80S ribosome. Nature, 497, 2013
4V7N	Glycocyamine kinase, beta-beta homodimer from marine worm Namalycastis sp., with transition state analog Mg(II)-ADP-NO3-glycocyamine. Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANIDINO ACETATE, Glycocyamine kinase beta chain, ... Authors: Lim, K, Pullalarevu, S, Herzberg, O. Deposit date: 2009-12-15 Release date: 2014-07-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for the mechanism and substrate specificity of glycocyamine kinase, a phosphagen kinase family member. Biochemistry, 49, 2010
4V7V	Crystal structure of the E. coli ribosome bound to clindamycin. Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Dunkle, J.A, Xiong, L, Mankin, A.S, Cate, J.H.D. Deposit date: 2010-08-16 Release date: 2014-07-09 Last modified: 2014-12-10 Method: X-RAY DIFFRACTION (3.2891 Å) Cite: Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc.Natl.Acad.Sci.USA, 107, 2010
3TEJ	Crystal structure of a domain fragment involved in peptide natural product biosynthesis Descriptor: Enterobactin synthase component F Authors: Liu, Y, Zheng, T, Bruner, S.D. Deposit date: 2011-08-15 Release date: 2012-01-18 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for phosphopantetheinyl carrier domain interactions in the terminal module of nonribosomal peptide synthetases. Chem.Biol., 18, 2011
4V52	Crystal structure of the bacterial ribosome from Escherichia coli in complex with neomycin. Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Borovinskaya, M.A, Pai, R.D, Zhang, W, Schuwirth, B.-S, Holton, J.M, Hirokawa, G, Kaji, H, Kaji, A, Cate, J.H.D. Deposit date: 2007-06-15 Release date: 2014-07-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.21 Å) Cite: Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat.Struct.Mol.Biol., 14, 2007
4V8G	Crystal structure of RMF bound to the 70S ribosome. Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... Authors: Polikanov, Y.S, Blaha, G.M, Steitz, T.A. Deposit date: 2011-12-11 Release date: 2014-07-09 Last modified: 2014-12-10 Method: X-RAY DIFFRACTION (3 Å) Cite: How hibernation factors RMF, HPF, and YfiA turn off protein synthesis. Science, 336, 2012
4V5H	E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide. Descriptor: 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... Authors: Seidelt, B, Innis, C.A, Wilson, D.N, Gartmann, M, Armache, J, Villa, E, Trabuco, L.G, Becker, T, Mielke, T, Schulten, K, Steitz, T.A, Beckmann, R. Deposit date: 2009-10-26 Release date: 2014-07-09 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Structural insight into nascent polypeptide chain-mediated translational stalling. Science, 326, 2009
2XA9	Crystal structure of trehalose synthase TreT mutant E326A from P. horikoshii in complex with UDPG Descriptor: TREHALOSE-SYNTHASE TRET, URIDINE-5'-DIPHOSPHATE-GLUCOSE Authors: Song, H.-N, Jung, T.-Y, Yoon, S.-M, Lee, S.-B, Lim, M.-Y, Woo, E.-J. Deposit date: 2010-03-30 Release date: 2011-03-16 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Insights on the New Mechanism of Trehalose Synthesis by Trehalose Synthase Tret from Pyrococcus Horikoshii. J.Mol.Biol., 404, 2010
4V5Z	Structure of a mammalian 80S ribosome obtained by docking homology models of the RNA and proteins into an 8.7 A cryo-EM map Descriptor: 18S Ribosomal RNA, 28S Ribosomal RNA, 40S Ribosomal protein RACK1, ... Authors: Chandramouli, P, Akey, C.W. Deposit date: 2008-03-27 Release date: 2014-07-09 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (8.7 Å) Cite: Structure of the Mammalian 80S Ribosome at 8.7 A Resolution Structure, 16, 2008
4V9D	Structures of the bacterial ribosome in classical and hybrid states of tRNA binding Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Dunkle, J.A, Wang, L, Feldman, M.B, Pulk, A, Chen, V.B, Kapral, G.J, Noeske, J, Richardson, J.S, Blanchard, S.C, Cate, J.H.D. Deposit date: 2012-07-31 Release date: 2014-07-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. Science, 332, 2011
4V68	T. thermophilus 70S ribosome in complex with mRNA, tRNAs and EF-Tu.GDP.kirromycin ternary complex, fitted to a 6.4 A Cryo-EM map. Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Schuette, J.-C, Spahn, C.M.T. Deposit date: 2008-12-11 Release date: 2014-07-09 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (6.4 Å) Cite: GTPase activation of elongation factor EF-Tu by the ribosome during decoding Embo J., 28, 2009
4V6H	Crystal structure of succinate-semialdehyde dehydrogenase from Burkholderia pseudomallei Descriptor: Succinate-semialdehyde dehydrogenase (NADP+) Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2009-07-24 Release date: 2014-07-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of succinate-semialdehyde dehydrogenase from Burkholderia pseudomallei To be Published
4W2H	Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... Authors: Polikanov, Y.S, Osterman, I.A, Szal, T, Tashlitsky, V.N, Serebryakova, M.V, Kusochek, P, Bulkley, D, Malanicheva, I.A, Efimenko, T.A, Efremenkova, O.V, Konevega, A.L, Shaw, K.J, Bogdanov, A.A, Rodnina, M.V, Dontsova, O.A, Mankin, A.S, Steitz, T.A, Sergiev, P.V. Deposit date: 2014-09-12 Release date: 2014-10-15 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Mol.Cell, 56, 2014
4V6Q	Structural characterization of mRNA-tRNA translocation intermediates (class 5 of the six classes) Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Agirrezabala, X, Liao, H, Schreiner, E, Fu, J, Ortiz-Meoz, R.F, Schulten, K, Green, R, Frank, J. Deposit date: 2011-12-08 Release date: 2014-07-09 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (11.5 Å) Cite: Structural characterization of mRNA-tRNA translocation intermediates. Proc.Natl.Acad.Sci.USA, 109, 2012
8J07	96nm repeat of human respiratory doublet microtubule and associated axonemal complexes Descriptor: ACTA2, Axonemal dynein light intermediate polypeptide 1, Calaxin, ... Authors: Gui, M, Brown, A. Deposit date: 2023-04-09 Release date: 2023-07-26 Last modified: 2023-08-02 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Axonemal structures reveal mechanoregulatory and disease mechanisms. Nature, 618, 2023
4V73	E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5a) Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Blau, C, Bock, L.V, Schroder, G.F, Davydov, I, Fischer, N, Stark, H, Rodnina, M.V, Vaiana, A.C, Grubmuller, H. Deposit date: 2013-10-14 Release date: 2014-07-09 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (15 Å) Cite: Energy barriers and driving forces in tRNA translocation through the ribosome. Nat.Struct.Mol.Biol., 20, 2013
4V7H	Structure of the 80S rRNA and proteins and P/E tRNA for eukaryotic ribosome based on cryo-EM map of Thermomyces lanuginosus ribosome at 8.9A resolution Descriptor: 18S rRNA, 26S ribosomal RNA, 40S ribosomal protein S0(A), ... Authors: Taylor, D.J, Devkota, B, Huang, A.D, Topf, M, Narayanan, E, Sali, A, Harvey, S.C, Frank, J. Deposit date: 2009-09-22 Release date: 2014-07-09 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (8.9 Å) Cite: Comprehensive molecular structure of the eukaryotic ribosome. Structure, 17, 2009
4WC8	Heterogeneous dodecamer formed from macrocycles containing a sequence from beta-2-microglobulin(63-69). Descriptor: CHLORIDE ION, ORN-TYR-LEU-LEU-PHI-TYR-THR-GLU-ORN-LYS-VAL-ALA-MAA-ALA-VAL-LYS, ORN-TYR-LEU-LEU-PHI-TYR-THR-GLU-ORN-LYS-VAL-ALA-MLE-ALA-VAL-LYS, ... Authors: Spencer, R.K, Nowick, J.S. Deposit date: 2014-09-04 Release date: 2015-05-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.908 Å) Cite: X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin. J.Am.Chem.Soc., 137, 2015
3ES9	NADPH-Cytochrome P450 Reductase in an Open Conformation Descriptor: FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Hamdane, D, Xia, C, Im, S.-C, Zhang, H, Kim, J.-J, Waskell, L. Deposit date: 2008-10-05 Release date: 2009-01-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450 J.Biol.Chem., 284, 2009

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