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6M63
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BU of 6m63 by Molmil
Crystal structure of a cAMP sensor G-Flamp1.
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Chimera of Cyclic nucleotide-gated potassium channel mll3241 and Yellow fluorescent protein
Authors:Zhou, Z, Chen, S, Wang, L, Chu, J.
Deposit date:2020-03-12
Release date:2021-09-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging.
Nat Commun, 13, 2022
6IAX
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BU of 6iax by Molmil
MloK1 model from single particle analysis of 2D crystals, class 1 (extended conformation)
Descriptor: Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION
Authors:Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H.
Deposit date:2018-11-27
Release date:2019-04-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM.
Nat Commun, 10, 2019
6I9D
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BU of 6i9d by Molmil
MloK1 consensus structure from single particle analysis of 2D crystals
Descriptor: Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION
Authors:Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H.
Deposit date:2018-11-23
Release date:2019-04-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM.
Nat Commun, 10, 2019
6HYQ
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BU of 6hyq by Molmil
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi bound to guanosine
Descriptor: ACETATE ION, GUANOSINE, Protein kinase A regulatory subunit
Authors:Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M.
Deposit date:2018-10-22
Release date:2019-11-13
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi in complex with guanosine
to be published
6HYI
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BU of 6hyi by Molmil
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.4 A resolution in complex with inosine
Descriptor: INOSINE, Protein kinase A regulatory subunit
Authors:Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M.
Deposit date:2018-10-22
Release date:2019-11-13
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (1.39944851 Å)
Cite:Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
6HQ7
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BU of 6hq7 by Molmil
Structure of EAL Enzyme Bd1971 - cGMP bound form
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, EAL Enzyme Bd1971, MAGNESIUM ION
Authors:Lovering, A.L, Cadby, I.T.
Deposit date:2018-09-24
Release date:2019-07-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.
Embo J., 38, 2019
6HQ5
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BU of 6hq5 by Molmil
Structure of EAL Enzyme Bd1971 - cAMP and cyclic-di-GMP bound form
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, ...
Authors:Lovering, A.L, Cadby, I.T.
Deposit date:2018-09-24
Release date:2019-07-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.
Embo J., 38, 2019
6HQ4
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BU of 6hq4 by Molmil
Structure of EAL enzyme Bd1971 - cAMP bound form
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, EAL Enzyme Bd1971, MAGNESIUM ION
Authors:Lovering, A.L, Cadby, I.T.
Deposit date:2018-09-24
Release date:2019-07-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.
Embo J., 38, 2019
6HQ3
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BU of 6hq3 by Molmil
Structure of EAL Enzyme Bd1971 - halfsite-occupied form
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, EAL Enzyme Bd1971
Authors:Lovering, A.L, Cadby, I.T.
Deposit date:2018-09-24
Release date:2019-07-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.
Embo J., 38, 2019
6HQ2
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BU of 6hq2 by Molmil
Structure of EAL Enzyme Bd1971 - apo form
Descriptor: EAL Enzyme Bd1971
Authors:Lovering, A.L, Cadby, I.T.
Deposit date:2018-09-24
Release date:2019-07-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.
Embo J., 38, 2019
6H7E
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BU of 6h7e by Molmil
GEF regulatory domain
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cDNA FLJ56134, ...
Authors:Ferrandez, Y, Cherfils, J, Peurois, F.
Deposit date:2018-07-31
Release date:2020-02-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Membranes prime the RapGEF EPAC1 to transduce cAMP signaling.
Nat Commun, 14, 2023
6H4G
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BU of 6h4g by Molmil
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei: E311A, T318R, V319A mutant bound to cAMP in the A site
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, INOSINE, Protein kinase A regulatory subunit
Authors:Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M.
Deposit date:2018-07-21
Release date:2019-08-14
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.143517 Å)
Cite:Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
6GYO
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BU of 6gyo by Molmil
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ...
Authors:Shintre, C.A, Pike, A.C.W, Tessitore, A, Young, M, Bushell, S.R, Strain-Damerell, C, Mukhopadhyay, S, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2018-06-30
Release date:2019-05-01
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
To Be Published
6GYN
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BU of 6gyn by Molmil
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Authors:Shintre, C.A, Pike, A.C.W, Tessitore, A, Young, M, Bushell, S.R, Strain-Damerell, C, Mukhopadhyay, S, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2018-06-30
Release date:2019-05-08
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
To Be Published
6FTF
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BU of 6ftf by Molmil
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.09 A resolution
Descriptor: 1,2-ETHANEDIOL, 7-cyano-7-deazainosine, Protein kinase A regulatory subunit, ...
Authors:Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M.
Deposit date:2018-02-21
Release date:2019-04-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.09151936 Å)
Cite:Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma.
Nat Commun, 10, 2019
6FLO
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BU of 6flo by Molmil
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei at 2.1 Angstrom resolution
Descriptor: GLYCEROL, INOSINE, Protein kinase A regulatory subunit
Authors:Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M.
Deposit date:2018-01-26
Release date:2019-08-14
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.13868666 Å)
Cite:Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
6EO1
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BU of 6eo1 by Molmil
The electron crystallography structure of the cAMP-bound potassium channel MloK1 (PCO-refined)
Descriptor: Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION
Authors:Kowal, J, Biyani, N, Chami, M, Scherer, S, Rzepiela, A, Baumgartner, P, Upadhyay, V, Nimigean, C, Stahlberg, H.
Deposit date:2017-10-08
Release date:2017-12-27
Last modified:2024-05-15
Method:ELECTRON CRYSTALLOGRAPHY (4.5 Å)
Cite:High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer.
Structure, 26, 2018
6DT4
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BU of 6dt4 by Molmil
1.8 Angstrom Resolution Crystal Structure of cAMP-Regulatory Protein from Yersinia pestis in Complex with cAMP
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CHLORIDE ION, Cyclic AMP receptor protein
Authors:Minasov, G, Shuvalova, L, Kiryukhina, O, Ritzert, J.T.H, Anderson, W.F, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2018-06-15
Release date:2018-06-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Cyclic AMP Receptor Protein Regulates Quorum Sensing and Global Gene Expression in Yersinia pestis during Planktonic Growth and Growth in Biofilms.
Mbio, 10, 2019
6CPB
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BU of 6cpb by Molmil
Crystal structure of the heme domain of CooA from Carboxydothermus hydrogenoformans
Descriptor: Carbon monoxide oxidation system transcription regulator CooA-1, GLYCEROL, SULFATE ION
Authors:Tripathi, S.M, Poulos, T.L.
Deposit date:2018-03-13
Release date:2018-05-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.155 Å)
Cite:Testing the N-Terminal Velcro Model of CooA Carbon Monoxide Activation.
Biochemistry, 57, 2018
6CJU
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BU of 6cju by Molmil
Structure of the SthK cyclic nucleotide-gated potassium channel in complex with cAMP
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK cyclic nucleotide-gated potassium channel
Authors:Nimigean, C.M, Rheinberger, J.
Deposit date:2018-02-26
Release date:2018-08-01
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures.
Elife, 7, 2018
6CJT
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BU of 6cjt by Molmil
Structure of the SthK cyclic nucleotide-gated potassium channel in complex with cGMP
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CYCLIC GUANOSINE MONOPHOSPHATE, SthK cyclic nucleotide-gated potassium channel
Authors:Nimigean, C.M, Rheinberger, J.
Deposit date:2018-02-26
Release date:2018-08-01
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures.
Elife, 7, 2018
6CJQ
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BU of 6cjq by Molmil
Structure of the SthK cyclic nucleotide-gated potassium channel
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, SthK cyclic nucleotide-gated potassium channel
Authors:Nimigean, C.M, Rheinberger, J.
Deposit date:2018-02-26
Release date:2018-08-01
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures.
Elife, 7, 2018
6BYS
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BU of 6bys by Molmil
Structures of the PKA RI alpha holoenzyme with the FLHCC driver J-PKAc alpha or native PRKAc alpha
Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit
Authors:Cao, B, Lu, T.W, Martinez Fiesco, J.A, Tomasini, M, Fan, L, Simon, S.M, Taylor, S.S, Zhang, P.
Deposit date:2017-12-21
Release date:2019-04-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.75 Å)
Cite:Structures of the PKA RI alpha Holoenzyme with the FLHCC Driver J-PKAc alpha or Wild-Type PKAc alpha.
Structure, 27, 2019
6BYR
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BU of 6byr by Molmil
Structures of the PKA RI alpha holoenzyme with the FLHCC driver J-PKAc alpha or native PKAc alpha
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha chimera, MAGNESIUM ION, ...
Authors:Cao, B, Lu, T.W, Martinez Fiesco, J.A, Tomasini, M, Fan, L, Simon, S.M, Taylor, S.S, Zhang, P.
Deposit date:2017-12-21
Release date:2019-04-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.661 Å)
Cite:Structures of the PKA RI alpha Holoenzyme with the FLHCC Driver J-PKAc alpha or Wild-Type PKAc alpha.
Structure, 27, 2019
6BQ8
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BU of 6bq8 by Molmil
Joint X-ray/neutron structure of PKG II CNB-B domain in complex with 8-pCPT-cGMP
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(~2~H_2_)amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2-hydroxy-7-(~2~H)hydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl](~2~H)-1,9-dihydro-6H-purin-6-one, STRONTIUM ION, ...
Authors:Kim, C, Kovalevsky, A, Gerlits, O.
Deposit date:2017-11-27
Release date:2018-03-21
Last modified:2024-04-03
Method:NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION
Cite:Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator.
Biochemistry, 57, 2018

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